Search Result

Results for "

resonance

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bacterial (1) Bcl-2 Family (2) Biochemical Assay Reagents (8) Cathepsin (1) CMV (1) Dengue virus (1) Epigenetic Reader Domain (1) Flavivirus (1) Fluorescent Dye (9) Histone Acetyltransferase (1) IKK (1) Interleukin Related (1) Keap1-Nrf2 (1) MicroRNA (1) MMP (2) Neuropeptide Y Receptor (1) NF-κB (1) PIKfyve (1) Ras (1) Reactive Oxygen Species (2) SARS-CoV (1) Tau Protein (1) TRP Channel (1) VSV (1)
By Research Areas:	Cancer (13) Cardiovascular Disease (1) Infection (2) Inflammation/Immunology (5) Metabolic Disease (1) Neurological Disease (4)

By Targets:

Bacterial (1)

Bcl-2 Family (2)

Biochemical Assay Reagents (8)

Cathepsin (1)

CMV (1)

Dengue virus (1)

Epigenetic Reader Domain (1)

Flavivirus (1)

Fluorescent Dye (9)

Histone Acetyltransferase (1)

IKK (1)

Interleukin Related (1)

Keap1-Nrf2 (1)

MicroRNA (1)

MMP (2)

Neuropeptide Y Receptor (1)

NF-κB (1)

PIKfyve (1)

Ras (1)

Reactive Oxygen Species (2)

SARS-CoV (1)

Tau Protein (1)

TRP Channel (1)

VSV (1)

By Research Areas:

Cancer (13)

Cardiovascular Disease (1)

Infection (2)

Inflammation/Immunology (5)

Metabolic Disease (1)

Neurological Disease (4)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Inhibitory Antibodies

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D1080

EDANS 1 Publications Verification 1,5-EDANS	Fluorescent Dye	Others
EDANS (1,5-EDANS) is a novel and quenched fluorogenic substrate for assaying retroviral protease by resonance energy transfer (RET) .

HY-B0933

Gadoteridol 1 Publications Verification SQ-32692; Gd-HP-DO3A	Biochemical Assay Reagents	Neurological Disease
Gadoteridol is a gadolinium-based magnetic resonance imaging (MRI) contrast agent, used in the imaging of the central nervous system .

HY-W034551

DOTA-tri(t-butyl ester)	Others	Others
DOTA-tri(t-butyl ester) can be used in the synthesis of generations 3 (G3) nanoglobular magnetic resonance imaging (MRI) contrast agents for MR angiography and tumor angiogenesis imaging .

HY-B0933A

Gadoteridol pentahydrate SQ-32692 pentahydrate; Gd-HP-DO3A pentahydrate	Biochemical Assay Reagents	Neurological Disease
Gadoteridol pentahydrate is a gadolinium-based magnetic resonance imaging (MRI) contrast agent, used in the imaging of the central nervous system .

HY-150979

Gd-NMC-3	Fluorescent Dye	Cancer
Gd-NMC-3 is a near-infrared fluorescence/magnetic resonance (NIRF/MR) bimodal imaging probe. Gd-NMC-3 shows high resolution and sensitivity in tumor imaging with good biocompatibility, indicating huge application potential .

HY-D1682

NFQ1	Fluorescent Dye	Others
NFQ1 is a non-fluorescent quencher (absorption wavelength: 474 nm), and is used for a new type of One Sample Fluorescence Resonance Energy Transfer (OS-FRET) method. OS-FRET enable measurement of unquenched donor emission in the same sample. NFQ1 shows broad absorption spectrum ensuring its utility as a dark acceptor for many donors .

HY-160477

DC-SX029	PIKfyve NF-κB IKK	Inflammation/Immunology
DC-SX029 is a potent SNX10 protein-protein interaction (PPI) inhibitor with an estimated K_D constant of ~0.935 μM by surface plasmon resonance (SPR). DC-SX029 blocks the SNX10-PIKfyve interaction, thereby decreased the TBK1/c-Rel signaling activation. DC-SX029 does not affect the protein level of SNX10. DC-SX029 has the potential for inflammatory bowel disease (IBD) research .

HY-A0266

Gadobenic acid

Biochemical Assay Reagents Others

Gadobenic acid, a complex of gadolinium with the ligand BOPTA, is an magnetic resonance imaging (MRI) contrast agent .

Gadobenic acid	Biochemical Assay Reagents	Others
Gadobenic acid, a complex of gadolinium with the ligand BOPTA, is an magnetic resonance imaging (MRI) contrast agent .

HY-16217A

Gadobutrol hydrate ZK 135079 hydrate	Biochemical Assay Reagents	Others
Gadobutrol (ZK 135079) hydrate is a nonionic paramagnetic macrocyclic gadolinium-based contrast agent that can be used for magnetic resonance imaging (MRI) .

HY-147151

AMCPy

Others Others

AMCPy is a potent electron paramagnetic resonance (EPR) brain imaging agent, possessing excellent lipophilicity for blood−brain barrier (BBB) penetration .

AMCPy	Others	Others
AMCPy is a potent electron paramagnetic resonance (EPR) brain imaging agent, possessing excellent lipophilicity for blood−brain barrier (BBB) penetration .

HY-136476A

Mn(II) protoporphyrin IX	Biochemical Assay Reagents	Others
Mn(II) protoporphyrin IX is a potential intravenous paramagnetic magnetic resonance contrast agent. Mn(II) protoporphyrin IX maintains strong paramagnetic properties .

HY-101533

AZD-5991 Maximum Cited Publications 8 Publications Verification	Bcl-2 Family	Cancer
AZD-5991 is a potent and selective Mcl-1 inhibitor with an IC₅₀ of 0.7 nM in FRET assay and a K_d of 0.17 nM in surface plasmon resonance (SPR) assay .

HY-B1724

Perflubron Perfluorooctyl bromide; 1-Bromoperfluorooctane; PFOB
Perflubron (Perfluorooctyl bromide) is a contrast medium for *magnetic resonance* imaging and sonography**. Perflubron can be emulsified with egg phospholipids (EYP) and shows exceptionally fast excretion characteristics .

HY-16217

Gadobutrol 1 Publications Verification ZK 135079	Biochemical Assay Reagents	Cancer
Gadobutrol (Gd-DO3A-butrol; ZK 135079) is a nonionic paramagnetic macrocyclic gadolinium-based contrast agent that can be used for magnetic resonance imaging (MRI) .

HY-A0167

Gadopentetate dimeglumine 2 Publications Verification SH-L-451A; Gadopentetic acid dimeglumine salt	Others	Cancer
Gadopentetate dimeglumine (SH-L-451A) is used in combination with magnetic resonance imaging (MRI) to allow blood vessels, organs, and other non-bony tissues to be seen more clearly on the MRI.

HY-101027

GSK 4027 1 Publications Verification
GSK 4027 is a chemical probe for the PCAF/GCN5 bromodomain with an pIC₅₀ of 7.4±0.11 for PCAF in a time-resolved fluorescence resonance energy transfer (TR-FRET) assay.

HY-W324458

MCA succinimidyl ester	Fluorescent Dye	Others
MCA succinimidyl ester is a derivative of MCA (HY-W027544). MCA succinimidyl ester has succinimidyl ester can react selectively with amines. MCA succinimidyl ester can be used as peptide substrate for fluorescence resonance energy transfer .

HY-13963

ZCL278 2 Publications Verification	Flavivirus Dengue virus VSV Ras	Cancer
ZCL278 is a selective Cdc42 modulator that directly binds to Cdc42 and inhibits its functions with K_d of 11.4 μM for Cdc42-ZCL278 affinity in surface plasmon resonance (SPR) experiment.

HY-101027A

GSK4028 1 Publications Verification	Epigenetic Reader Domain Histone Acetyltransferase	Inflammation/Immunology Cancer
GSK4028 is the enantiomeric negative control of GSK4027, which is a PCAF/GCN5 bromodomain chemical probe, the pIC₅₀ of GSK4028 is 4.9 in a time-resolved fluorescence resonance energy transfer (TR-FRET) assay.

HY-157558

KDRLKZ-1 8SGE	Others	Others
KDRLKZ-1 is a KLHDC2 ligand (K_d = 0.36 μM), with IC₅₀s of 0.21 μM and 0.31 μM in alphaLISA and time-resolved fluorescence resonance energy transfer (TR-FRET) displacement assays .

HY-101533B

AZD-5991 (S-enantiomer)	Bcl-2 Family	Cancer
AZD-5991 S-enantiomer is the less active enantiomer of AZD-5991. AZD-5991 S-enantiomer is a Mcl-1 inhibitor with an IC₅₀ of 6.3 μM in FRET assay and a K_d of 0.98 μM in surface plasmon resonance (SPR) assay.

HY-148465

Gadoteric acid	Biochemical Assay Reagents	Cardiovascular Disease Cancer
Gadoteric acid is a macrocyclic, paramagnetic, gadolinium-based contrast agent that can be used for magnetic resonance imaging (MRI) of the brain, spine, and related tissues. In particular, Gadoteric acid is able to detect and visualize areas of blood-brain barrier disruption and abnormal vascular distribution .

HY-18743

Coelenterazine 2 Publications Verification	Reactive Oxygen Species	Cancer
Coelenterazine is a luminescent enzyme substrate for apoaequorin and Renilla luciferase. Renilla luciferase and substrate coelenterazine has been used as the bioluminescence donor in bioluminescence resonance energy transfer (BRET) to detect protein-protein interactions. Coelenterazine is a superoxide anion-sensitive chemiluminescent probe and it can also be used in chemiluminescent detection of peroxynitrite .

HY-16219

Gadoxetate Disodium Gd-EOB-DTPA Disodium; ZK 139834	Biochemical Assay Reagents	Cancer
Gadoxetate Disodium (Gd-EOB-DTPA Disodium) is a contrast agent in magnetic resonance imaging (MRI) of the hepatobiliary system, which accumulates in normal, functioning hepatocytes. Gadoxetate Disodium (Gd-EOB-DTPA Disodium) is used to evaluate focal liver lesions, such as hepatocellular carcinoma or liver metastasis on T1-weighted imaging .

HY-P99900

Sevirumab MSL-109	CMV	Infection
Sevirumab (MSL-109) is a human IgG1 neutralizing monoclonal antibody against cytomegalovirus (CMV). Sevirumab recognizes CMV gH complexes and inhibits CMV replication with an EC₅₀ of 0.3 μg/mL .

HY-100468

REV7/REV3L-IN-1	Others	Cancer
REV7/REV3L-IN-1 is a REV7/REV3L interaction inhibitor with an IC₅₀ of 78 μM, which directly binds to REV7 in nuclear magnetic resonance analyses, and inhibits the reactivation of a reporter plasmid containing an interstrand crosslink (ICL) in between the promoter and reporter regions .

HY-P3722

Mca-PLAQAV-Dpa-RSSSR-NH2	Fluorescent Dye MMP	Others
Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescent peptide and as one of fluorescent substrates of TNF-α converting enzyme (TACE; ADAM17), ADAM 9 and ADAM 10. Mca-PLAQAV-Dpa-RSSSR-NH2 is a substrate based on fluorescence resonance energy transfer, and its activity can be determined by the change of fluorescence intensity during pyrolysis .

HY-P3722A

Mca-PLAQAV-Dpa-RSSSR-NH2 TFA	Fluorescent Dye MMP	Others
Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescent peptide and as one of fluorescent substrates of TNF-α converting enzyme (TACE); ADAM17, ADAM 9 and ADAM 10. Mca-PLAQAV-Dpa-RSSSR-NH2 is a substrate based on fluorescence resonance energy transfer, and its activity can be determined by the change of fluorescence intensity during pyrolysis .

HY-P9949

Reslizumab Sch 55700	Interleukin Related	Inflammation/Immunology
Reslizumab (Sch 55700) is humanized monoclonal antibodies that target interleukin-5 (IL-5) for the treatment of eosinophilic asthma. Reslizumab is effective in neutralizing the function of IL-5. Reslizumab has high binding affinity for human IL-5, with K_D values of 109 pM and 4.3 pM in the the Biacore surface plasmon resonance and Kinetic Exclusion Assay, respectively .

HY-118462A

Coelenteramine 400a hydrochloride Coelenterazine 400a hydrochloride; Bisdeoxycoelenterazine hydrochloride	Others	Others
Coelenteramine (Coelenterazine) 400a hydrochloride, a derivative of Coelenterazine, is a Renilla luciferase (RLuc) substrate. In the presence of Coelenteramine 400a hydrochloride, RLuc can emit blue light at 395 nm . Coelenteramine 400a hydrochloride will causes color change in the bioluminescence reaction of Rluc by replacing the sulfur and oxygen heteroatoms of the methylene bridge. Coelenteramine 400a hydrochloride provides higher signal resolution and can be used in the research of bioluminescence resonance energy transfer (BRET) .

HY-P4920

Mca-SEVNLDAEFK(Dnp)-NH2	Fluorescent Dye	Others
Mca-SEVNLDAEFK(Dnp)-NH2 contains a highly fluorescent 7-methoxycoumarin group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl group. It can be used to measure the activities of peptidases that are capable of cleaving an amide bond between the fluorescent group and the quencher group, causing an increase in fluorescence, such as can be used to measure the activity of BACE-1 .

HY-118462

Coelenteramine 400a Coelenterazine 400a; Bisdeoxycoelenterazine	Fluorescent Dye	Others
Coelenteramine 400a (Coelenterazine 400a), a derivative of Coelenterazine, is a Renilla luciferase (RLuc) substrate. In the presence of Coelenteramine 400a, RLuc can emit blue light at 395 nm . Coelenterazine 400a will causes color change in the bioluminescence reaction of Rluc by replacing the sulfur and oxygen heteroatoms of the methylene bridge. Coelenterazine 400a provides higher signal resolution and can be used in the research of bioluminescence resonance energy transfer (BRET) .

HY-124304

Pinokalant LOE-908	TRP Channel SARS-CoV	Neurological Disease
Pinokalant is a broad-spectrum and non-selectivecation channel inhibitor. Pinokalant significantly reduces cortical infarct volume. Pinokalant o improves the metabolic and electrophysiologic status of the ischemic penumbra. Pinokalant reduces lesion size on magnetic resonance images in the acute phase following middle cerebral artery occlusion in rats. Pinokalant has the potential for the research of stroke. Pinokalant also shows anti-SARS-CoV-2 activity .

HY-106594A

Prussian blue insoluble Iron(III) ferrocyanide; Milori blue	Bacterial	Infection Others Cancer
Prussian blue insoluble (Iron(III) ferrocyanide) is a good adsorbent to be used as antidotes for poisoning with cesium or thallium ions. Prussian blue insoluble (Iron(III) ferrocyanide) has anticancerous and antibacterial properties. Prussian blue insoluble (Iron(III) ferrocyanide) can be used as a contrast agent in photoacoustic and magnetic resonance imaging (MRI). Prussian blue insoluble can be used for contrast agents, antidotes and cancer research .

HY-160481

MG-1102	Tau Protein MicroRNA	Neurological Disease
MG-1102 is first-in-class dual binder of monomeric tau and pre-miRNA-146a. MG-1102 shows specific inhibition of miRNA146a with IC₅₀s of 0.21 mM and 0.36 mM specific inhibition of doublelabeled pre-miRNA146a and mono-labeled pre-miRNA146a, respectively. MG-1102 interacts with tau monomers with a K_d of 3.21 mM by surface plasmon resonance (SPR). MG-1102 is a potential multi-target-directed ligands (MTDLs) for Alzheimer’s disease (AD) .

HY-D1703

Oxazine 170 perchlorate	Fluorescent Dye	Others
Oxazine 170 perchlorate is a laser dye with a wide excitation spectrum range (300−550 nm), which strongly absorbs light with a wavelength greater than 550 nm, and it emits fluorescence with a wavelength of about 645 nm .

HY-135152

CYPMPO	Reactive Oxygen Species	Cancer
CYPMPO is a spin-trapping reagent. CYPMPO, a cyclic DEPMPO-type nitrone, is evaluated for spin-trapping capabilities toward hydroxyl and superoxide radicals. anti-oxidant and anti-tumor activity .

HY-P4805

Peptide YY (13-36) (canine, mouse, porcine, rat)

Neuropeptide Y Receptor Metabolic Disease

Peptide YY (13-36) (canine, mouse, porcine, rat) is a Y₂ receptor subtype agonist .

Peptide YY (13-36) (canine, mouse, porcine, rat)	Neuropeptide Y Receptor	Metabolic Disease
Peptide YY (13-36) (canine, mouse, porcine, rat) is a Y₂ receptor subtype agonist .

HY-146578

Keap1-Nrf2-IN-8	Keap1-Nrf2	Inflammation/Immunology
Keap1-Nrf2-IN-8 (compound 12d) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein−protein interaction) inhibitor with IC₅₀s of 64.5 nM and 14.2 nM for FP and TR-FRET assays, respectively. Keap1-Nrf2-IN-8 significantly increases the mRNA levels of Nrf2 downstream genes, GSTM3, HMOX2 and NQO1 .

HY-P10065

RKLLW-NH2

Cathepsin Inflammation/Immunology

RKLLW-NH2 is a Cathepsin L inhibitor .
HY-N0926A

Columbamine chloride

Columbamin chloride; Dehydroisocorypalmine chloride
Others Others

Columbamine (Columbamin; Dehydroisocorypalmine) chloride is an alkaloid .

RKLLW-NH2	Cathepsin	Inflammation/Immunology
RKLLW-NH2 is a Cathepsin L inhibitor .

Columbamine chloride Columbamin chloride; Dehydroisocorypalmine chloride	Others	Others
Columbamine (Columbamin; Dehydroisocorypalmine) chloride is an alkaloid .

Cat. No.	Product Name	Type

HY-D1080

EDANS 1 Publications Verification 1,5-EDANS	Fluorescent Dyes/Probes
EDANS (1,5-EDANS) is a novel and quenched fluorogenic substrate for assaying retroviral protease by resonance energy transfer (RET) .

HY-18743

Coelenterazine 2 Publications Verification	Fluorescent Dyes/Probes
Coelenterazine is a luminescent enzyme substrate for apoaequorin and Renilla luciferase. Renilla luciferase and substrate coelenterazine has been used as the bioluminescence donor in bioluminescence resonance energy transfer (BRET) to detect protein-protein interactions. Coelenterazine is a superoxide anion-sensitive chemiluminescent probe and it can also be used in chemiluminescent detection of peroxynitrite .

Coelenterazine

2 Publications Verification

Fluorescent Dyes/Probes

Coelenterazine is a luminescent enzyme substrate for apoaequorin and Renilla luciferase. Renilla luciferase and substrate coelenterazine has been used as the bioluminescence donor in bioluminescence resonance energy transfer (BRET) to detect protein-protein interactions. Coelenterazine is a superoxide anion-sensitive chemiluminescent probe and it can also be used in chemiluminescent detection of peroxynitrite .

HY-150979

Gd-NMC-3	Fluorescent Dyes/Probes
Gd-NMC-3 is a near-infrared fluorescence/magnetic resonance (NIRF/MR) bimodal imaging probe. Gd-NMC-3 shows high resolution and sensitivity in tumor imaging with good biocompatibility, indicating huge application potential .

HY-D1682

NFQ1	Fluorescent Dyes/Probes
NFQ1 is a non-fluorescent quencher (absorption wavelength: 474 nm), and is used for a new type of One Sample Fluorescence Resonance Energy Transfer (OS-FRET) method. OS-FRET enable measurement of unquenched donor emission in the same sample. NFQ1 shows broad absorption spectrum ensuring its utility as a dark acceptor for many donors .

HY-W324458

MCA succinimidyl ester	Fluorescent Dyes/Probes
MCA succinimidyl ester is a derivative of MCA (HY-W027544). MCA succinimidyl ester has succinimidyl ester can react selectively with amines. MCA succinimidyl ester can be used as peptide substrate for fluorescence resonance energy transfer .

HY-118462

Coelenteramine 400a

Coelenterazine 400a; Bisdeoxycoelenterazine

Dyes

Coelenteramine 400a (Coelenterazine 400a), a derivative of Coelenterazine, is a Renilla luciferase (RLuc) substrate. In the presence of Coelenteramine 400a, RLuc can emit blue light at 395 nm . Coelenterazine 400a will causes color change in the bioluminescence reaction of Rluc by replacing the sulfur and oxygen heteroatoms of the methylene bridge. Coelenterazine 400a provides higher signal resolution and can be used in the research of bioluminescence resonance energy transfer (BRET) .

HY-D1703

Oxazine 170 perchlorate	Fluorescent Dyes/Probes
Oxazine 170 perchlorate is a laser dye with a wide excitation spectrum range (300−550 nm), which strongly absorbs light with a wavelength greater than 550 nm, and it emits fluorescence with a wavelength of about 645 nm .

Cat. No.	Product Name	Target	Research Area

HY-P5229A

IHRIC TFA	Peptides	Others
IHRIC TFA is a penta-peptide, correlated positively with hairpin DNA with tetramer loops. Therefore, IHRIC TFA joins hands with hairpin DNA (hpDNA) with improved selectivity as sensing materials in the detection system, used for surface plasmon resonance imaging (SPRi) .

HY-P5228A

KSDSC TFA	Peptides	Others
KSDSC TFA is a penta-peptide, correlated positively with hairpin DNA with tetramer loops. Therefore, KSDSC TFA joins hands with hairpin DNA (hpDNA) with improved selectivity as sensing materials in the detection system, used for surface plasmon resonance imaging (SPRi) .

HY-P5228

KSDSC	Peptides	Others
KSDSC is a penta-peptide, correlated positively with hairpin DNA with tetramer loops. Therefore, KSDSC joins hands with hairpin DNA (hpDNA) with improved selectivity as sensing materials in the detection system, used for surface plasmon resonance imaging (SPRi) .

HY-P5229

IHRIC	Peptides	Others
IHRIC is a penta-peptide, correlated positively with hairpin DNA with tetramer loops. Therefore, IHRIC joins hands with hairpin DNA (hpDNA) with improved selectivity as sensing materials in the detection system, used for surface plasmon resonance imaging (SPRi) .