SK-216

Cat. No.: HY-122714: FAQs
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SK-216 is a plasminogen activator inhibitor-1 (PAI-1) inhibitor that acts as an anti-metastatic agent for human osteosarcoma and inhibits lung metastasis of human osteosarcoma.

For research use only. We do not sell to patients.

SK-216 Chemical Structure

CAS No. : 654080-03-2

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Description

SK-216 is a plasminogen activator inhibitor-1 (PAI-1) inhibitor that acts as an anti-metastatic agent for human osteosarcoma and inhibits lung metastasis of human osteosarcoma^[1].

In Vitro

SK-216 (0-50 μM, 48 h) can inhibit the invasion of 143B cells in a dose-dependent manner, but does not affect cell proliferation and migration^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis ^[1]

Cell Line:	human osteosarcoma cell line 143B
Concentration:	0, 25, 50 μM
Incubation Time:	48 h
Result:	Inhibited PAI-1 expression by 40% at concentrations of 25 and 50 μM，and lead to a significantly lower ratio of cell-invaded wells/total wells. Inhibited MMP-13 secretion in 143B cells.

In Vivo

SK-216 (i.p., 6.6 μg/200 μL in PBS, once every 3 days) inhibits lung metastasis of human osteosarcoma cells, but not tumor growth in primary tumors in male athymic nude mice with 143B-Luc cell model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	5-6-week-old male athymic nude mice with 143B-Luc cell^[1]
Dosage:	6.6 μg/200 μL in PBS
Administration:	i.p., once every 3 days
Result:	Resulted in a significant reduction in PAI-1 expression levels in primary lesions in mice.

Molecular Weight

533.52

Formula

C₂₉H₂₉NNa₂O₆

CAS No.

654080-03-2

SMILES

O=C(O[Na])C(CCCCCOC1=CC=C2C=C(C3=NC4=CC(C(C)(C)C)=CC=C4O3)C=CC2=C1)C(O[Na])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Minori Tsuge, et al. SK-216, a Novel Inhibitor of Plasminogen Activator Inhibitor-1, Suppresses Lung Metastasis of Human Osteosarcoma. Int J Mol Sci. 2018 Mar 5;19(3):736.

SK-216 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SK-216654080-03-2SK216SK 216PAI-1Plasminogen activator inhibitor-1plasminogenosteosarcomametastasisInhibitorinhibitorinhibit

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