2. Cell Cycle/DNA Damage Antibody-drug Conjugate/ADC Related Autophagy
  3. Topoisomerase ADC Cytotoxin Autophagy
  4. SN-38-d3

SN-38-d3 is the deuterium labeled SN-38. SN-38 (NK012) is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 (NK012) inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively[1][2][3][4].

For research use only. We do not sell to patients.

SN-38-d<sub>3</sub> Chemical Structure

SN-38-d3 Chemical Structure

CAS No. : 718612-49-8

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5 mg USD 1560 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of SN-38-d3:

SN-38-d3 Related Antibodies

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Description

SN-38-d3 is the deuterium labeled SN-38. SN-38 (NK012) is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 (NK012) inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively[1][2][3][4].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SN-38-d3 Related Antibodies
Molecular Weight

395.42

Formula

C22H17D3N2O5
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

[2H]C([2H])([2H])CC1=C2C(C(N3C2)=CC([C@](O)(C(OC4)=O)CC)=C4C3=O)=NC5=CC=C(O)C=C51
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (252.90 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5290 mL 12.6448 mL 25.2896 mL
5 mM 0.5058 mL 2.5290 mL 5.0579 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5290 mL 12.6448 mL 25.2896 mL 63.2239 mL
5 mM 0.5058 mL 2.5290 mL 5.0579 mL 12.6448 mL
10 mM 0.2529 mL 1.2645 mL 2.5290 mL 6.3224 mL
15 mM 0.1686 mL 0.8430 mL 1.6860 mL 4.2149 mL
20 mM 0.1264 mL 0.6322 mL 1.2645 mL 3.1612 mL
25 mM 0.1012 mL 0.5058 mL 1.0116 mL 2.5290 mL
30 mM 0.0843 mL 0.4215 mL 0.8430 mL 2.1075 mL
40 mM 0.0632 mL 0.3161 mL 0.6322 mL 1.5806 mL
50 mM 0.0506 mL 0.2529 mL 0.5058 mL 1.2645 mL
60 mM 0.0421 mL 0.2107 mL 0.4215 mL 1.0537 mL
80 mM 0.0316 mL 0.1581 mL 0.3161 mL 0.7903 mL
100 mM 0.0253 mL 0.1264 mL 0.2529 mL 0.6322 mL
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SN-38-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SN-38-d3718612-49-8NK012-d3TopoisomeraseADC CytotoxinAutophagyADC PayloadInhibitorinhibitorinhibit

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