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Products are for research use only. Not for human use. We do not sell to patients.

Signaling Pathway

SP600125

HY-12041

(SP 600125; SP-600125)

SP600125

SP600125 Chemical Structure

SP600125 is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM, respectively; 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MKK3, MKK6, PKB, and PKCα, and 100-fold selectivity against ERK2, p38, Chk1, EGFR etc.

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10 mM * 1 mL in DMSO $55 In-stock
10 mg $50 In-stock
50 mg $65 In-stock
100 mg $86 In-stock
200 mg Get quote
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Free sample   Apply now  
10 mM * 1 mL in DMSO €54 In-stock
10 mg €49 In-stock
50 mg €64 In-stock
100 mg €84 In-stock
200 mg Get quote
500 mg Get quote

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Product name: SP600125
Cat. No.: HY-12041

SP600125 Data Sheet

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    Purity: 98.87%

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Biological Activity of SP600125

SP600125 is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM, respectively; 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MKK3, MKK6, PKB, and PKCα, and 100-fold selectivity against ERK2, p38, Chk1, EGFR etc.
IC50 value: 40/40/90 nM(JNK1/2/3) [1]
Target: JNK
in vitro: SP600125 is originally characterized as a selective ATP-competitive inhibitor of c-Jun N-terminal kinase JNK. In Jurkat T cells, SP600125 inhibits the phosphorylation of c-Jun with IC50 of 5 μM to 10 μM. In CD4+ cells, such as Th0 cells isolated from either human cord or peripheral blood, SP600125 blocks cell activation and differentiation and inhibits the expression of inflammatory genes COX-2, IL-2, IL-10, IFN-γ, and TNF-α, with IC50 of 5 μM to 12 μM [1].  In a mouse beta cells MIN6, SP600125 (20 μM) induces the phosphorylation of p38 MAPK and its downstream CREB-dependent promoter activation [2]. n HCT116 cells, SP600125 (20 μM) blocks the G2 phase to mitosis transition and induces endoreplication. This ability of SP600125 is independent of JNK inhibition, but due to its inhibition of CDK1-cyclin B activation upstream of Aurora A and Polo-like kinase 1 [3].
in vivo: In mice, SP600125 (15 mg/kg or 30 mg/kg) significantly inhibits lipopolysaccharide (LPS)-induced TNF-α expression and anti-CD3-induced apoptosis of CD4+ CD8+ thymocytes [1].

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 220.23 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C14H8N2O
CAS No 129-56-6
Solvent & Solubility

DMSO ≥42mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 4.5407 mL 22.7035 mL 45.4071 mL
5 mM 0.9081 mL 4.5407 mL 9.0814 mL
10 mM 0.4541 mL 2.2704 mL 4.5407 mL

References on SP600125

Inhibitor Kit

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