2. Membrane Transporter/Ion Channel
  3. Na+/H+ Exchanger (NHE)
  4. Tenapanor hydrochloride

Tenapanor hydrochloride  (Synonyms: AZD1722 hydrochloride; RDX5791 hydrochloride)

Cat. No.: HY-15991A Purity: 98.71%
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Tenapanor (AZD1722) hydrochloride is a potent and orally active sodium/hydrogen exchanger isoform 3 (NHE3) inhibitor. Tenapanor hydrochloride reduces intestinal phosphate absorption predominantly through reduction of passive paracellular phosphate flux. Tenapanor hydrochloride has the potential for the research of hyperphosphatemia.

For research use only. We do not sell to patients.

Tenapanor hydrochloride Chemical Structure

Tenapanor hydrochloride Chemical Structure

CAS No. : 1234365-97-9

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10 mg USD 145 In-stock
25 mg USD 300 In-stock
50 mg USD 470 In-stock
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Based on 4 publication(s) in Google Scholar

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Tenapanor hydrochloride Related Antibodies

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Description

Tenapanor (AZD1722) hydrochloride is a potent and orally active sodium/hydrogen exchanger isoform 3 (NHE3) inhibitor. Tenapanor hydrochloride reduces intestinal phosphate absorption predominantly through reduction of passive paracellular phosphate flux. Tenapanor hydrochloride has the potential for the research of hyperphosphatemia[1][2].

In Vivo

Tenapanor hydrochloride (0.15, 0.5 mg/kg; p.o.) reduces passive paracellular phosphate absorption in rats[1].
Tenapanor hydrochloride (0.15 mg/kg; p.o.; twice-daily for 11 consecutive days) increases the reduction in urinary phosphorus excretion in rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats (intestinal loop model)[1]
Dosage: 0.15, 0.5 mg/kg
Administration: P.o.
Result: Reduced passive paracellular phosphate absorption by reduced urinary phosphate and sodium excretion after the high-phosphate meal and increased sodium and phosphate delivery to the cecum.
Animal Model: 8 weeks, 250 g male Sprague–Dawley rats[2]
Dosage: 0.15 mg/kg in combination with sevelamer (0%, 0.75%, 1.5%, and 3% (wt/wt))
Administration: Oral gavage; twice-daily for 11 consecutive days
Result: Significantly augmented the reduction in urinary phosphorus excretion.
Clinical Trial
Molecular Weight

1217.97

Formula

C50H68Cl6N8O10S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC=CC([C@@H]2CN(C)CC3=C2C=C(Cl)C=C3Cl)=C1)(NCCOCCOCCNC(NCCCCNC(NCCOCCOCCNS(=O)(C4=CC=CC([C@@H]5CN(C)CC6=C5C=C(Cl)C=C6Cl)=C4)=O)=O)=O)=O.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (82.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 20 mg/mL (16.42 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8210 mL 4.1052 mL 8.2104 mL
5 mM 0.1642 mL 0.8210 mL 1.6421 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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=
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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 0.8210 mL 4.1052 mL 8.2104 mL 20.5260 mL
5 mM 0.1642 mL 0.8210 mL 1.6421 mL 4.1052 mL
10 mM 0.0821 mL 0.4105 mL 0.8210 mL 2.0526 mL
15 mM 0.0547 mL 0.2737 mL 0.5474 mL 1.3684 mL
DMSO 20 mM 0.0411 mL 0.2053 mL 0.4105 mL 1.0263 mL
25 mM 0.0328 mL 0.1642 mL 0.3284 mL 0.8210 mL
30 mM 0.0274 mL 0.1368 mL 0.2737 mL 0.6842 mL
40 mM 0.0205 mL 0.1026 mL 0.2053 mL 0.5131 mL
50 mM 0.0164 mL 0.0821 mL 0.1642 mL 0.4105 mL
60 mM 0.0137 mL 0.0684 mL 0.1368 mL 0.3421 mL
80 mM 0.0103 mL 0.0513 mL 0.1026 mL 0.2566 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Tenapanor hydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tenapanor1234365-97-9AZD1722RDX5791AZD 1722AZD-1722RDX 5791RDX-5791Na+/H+ Exchanger (NHE)Sodium/hydrogen ExchangerSodium-hydrogen Exchangerintestinalphosphate absorptionhyperphosphatemiaorally activeInhibitorinhibitorinhibit

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