2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Tetrahydroalstonine

Tetrahydroalstonine, a indole alkaloid isolated from the fruits of Rhazya stricta, is a selective alpha 2-adrenoceptor antagonist.

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Tetrahydroalstonine Chemical Structure

Tetrahydroalstonine Chemical Structure

CAS No. : 6474-90-4

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 532 In-stock
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10 mM * 1 mL in DMSO USD 532 In-stock
Solid
1 mg USD 229 In-stock
5 mg USD 686 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Tetrahydroalstonine, a indole alkaloid isolated from the fruits of Rhazya stricta, is a selective alpha 2-adrenoceptor antagonist[1][2].

Molecular Weight

352.43

Formula

C21H24N2O3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(OC)C1=CO[C@@H](C)[C@@]2([H])[C@]1([H])C[C@@]3([H])C4=C(C5=CC=CC=C5N4)CCN3C2
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (283.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8374 mL 14.1872 mL 28.3744 mL
5 mM 0.5675 mL 2.8374 mL 5.6749 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8374 mL 14.1872 mL 28.3744 mL 70.9361 mL
5 mM 0.5675 mL 2.8374 mL 5.6749 mL 14.1872 mL
10 mM 0.2837 mL 1.4187 mL 2.8374 mL 7.0936 mL
15 mM 0.1892 mL 0.9458 mL 1.8916 mL 4.7291 mL
20 mM 0.1419 mL 0.7094 mL 1.4187 mL 3.5468 mL
25 mM 0.1135 mL 0.5675 mL 1.1350 mL 2.8374 mL
30 mM 0.0946 mL 0.4729 mL 0.9458 mL 2.3645 mL
40 mM 0.0709 mL 0.3547 mL 0.7094 mL 1.7734 mL
50 mM 0.0567 mL 0.2837 mL 0.5675 mL 1.4187 mL
60 mM 0.0473 mL 0.2365 mL 0.4729 mL 1.1823 mL
80 mM 0.0355 mL 0.1773 mL 0.3547 mL 0.8867 mL
100 mM 0.0284 mL 0.1419 mL 0.2837 mL 0.7094 mL
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Tetrahydroalstonine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tetrahydroalstonine6474-90-4Adrenergic ReceptorBeta ReceptorIndolealkaloidRhazyastrictaalpha2-adrenoceptorInhibitorinhibitorinhibit

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