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TIBI is a potent and ATP-competitive inhibitor of Rio1 (IC50: 0.09 μM, Ki: 0.05 μM). TIBI enhances the thermostability of the enzyme Rio1.

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TIBI Chemical Structure

TIBI Chemical Structure

CAS No. : 1196457-06-3

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1 mg USD 80 In-stock
5 mg USD 167 In-stock
10 mg USD 268 In-stock
25 mg USD 537 In-stock
50 mg USD 860 In-stock
100 mg USD 1380 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

TIBI is a potent and ATP-competitive inhibitor of Rio1 (IC50: 0.09 μM, Ki: 0.05 μM). TIBI enhances the thermostability of the enzyme Rio1[1].

IC50 & Target

IC50: 0.09 μM, Ki: 0.05 μM (Rio1)[1]
Molecular Weight

621.72

Formula

C7H2I4N2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

IC1=C2C(N=CN2)=C(C(I)=C1I)I
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (80.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6084 mL 8.0422 mL 16.0844 mL
5 mM 0.3217 mL 1.6084 mL 3.2169 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6084 mL 8.0422 mL 16.0844 mL 40.2110 mL
5 mM 0.3217 mL 1.6084 mL 3.2169 mL 8.0422 mL
10 mM 0.1608 mL 0.8042 mL 1.6084 mL 4.0211 mL
15 mM 0.1072 mL 0.5361 mL 1.0723 mL 2.6807 mL
20 mM 0.0804 mL 0.4021 mL 0.8042 mL 2.0106 mL
25 mM 0.0643 mL 0.3217 mL 0.6434 mL 1.6084 mL
30 mM 0.0536 mL 0.2681 mL 0.5361 mL 1.3404 mL
40 mM 0.0402 mL 0.2011 mL 0.4021 mL 1.0053 mL
50 mM 0.0322 mL 0.1608 mL 0.3217 mL 0.8042 mL
60 mM 0.0268 mL 0.1340 mL 0.2681 mL 0.6702 mL
80 mM 0.0201 mL 0.1005 mL 0.2011 mL 0.5026 mL
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TIBI Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TIBI1196457-06-3OthersATP-competitivethermostabilityRio1Inhibitorinhibitorinhibit

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