2. Metabolic Enzyme/Protease
  3. MetAP
  4. TP-004

TP-004 is a potent and reversible inhibitor of methionine aminopeptidase 2 (MetAP2), with an IC50 of 6 nM.

For research use only. We do not sell to patients.

TP-004 Chemical Structure

TP-004 Chemical Structure

CAS No. : 1454299-21-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 396 In-stock
Solution
10 mM * 1 mL in DMSO USD 396 In-stock
Solid
5 mg USD 360 In-stock
10 mg USD 580 In-stock
50 mg USD 1650 In-stock
100 mg USD 2650 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

TP-004 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

TP-004 is a potent and reversible inhibitor of methionine aminopeptidase 2 (MetAP2), with an IC50 of 6 nM[1].

IC50 & Target

IC50: 6 nM (MetAP2)[1]
Molecular Weight

363.34

Formula

C17H16F3N5O
CAS No.
Appearance

Solid

Color

Light yellow to khaki

SMILES

O[C@H]1CN(C2=NC=C(C3=CC(C(F)(F)F)=CC4=C3C=NN4)C(C)=N2)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (688.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7522 mL 13.7612 mL 27.5224 mL
5 mM 0.5504 mL 2.7522 mL 5.5045 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7522 mL 13.7612 mL 27.5224 mL 68.8061 mL
5 mM 0.5504 mL 2.7522 mL 5.5045 mL 13.7612 mL
10 mM 0.2752 mL 1.3761 mL 2.7522 mL 6.8806 mL
15 mM 0.1835 mL 0.9174 mL 1.8348 mL 4.5871 mL
20 mM 0.1376 mL 0.6881 mL 1.3761 mL 3.4403 mL
25 mM 0.1101 mL 0.5504 mL 1.1009 mL 2.7522 mL
30 mM 0.0917 mL 0.4587 mL 0.9174 mL 2.2935 mL
40 mM 0.0688 mL 0.3440 mL 0.6881 mL 1.7202 mL
50 mM 0.0550 mL 0.2752 mL 0.5504 mL 1.3761 mL
60 mM 0.0459 mL 0.2294 mL 0.4587 mL 1.1468 mL
80 mM 0.0344 mL 0.1720 mL 0.3440 mL 0.8601 mL
100 mM 0.0275 mL 0.1376 mL 0.2752 mL 0.6881 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

TP-004 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TP-0041454299-21-8TP004TP 004MetAPMethionine AminopeptidasemethionineaminopeptidaseMetAP2Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
TP-004
Cat. No.:
HY-120868
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.