1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. TRC-766

TRC-766 is a negative control of RTC-5 (TRC-382). TRC-766 binds protein phosphatase 2A (PP2A) and does not activate the phosphatase.

For research use only. We do not sell to patients.

TRC-766 Chemical Structure

TRC-766 Chemical Structure

CAS No. : 1810734-44-1

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10 mM * 1 mL in DMSO
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Description

TRC-766 is a negative control of RTC-5 (TRC-382). TRC-766 binds protein phosphatase 2A (PP2A) and does not activate the phosphatase[1].

In Vitro

As a pharmacologic control, the cells are treated with increasing doses of TRC-766, which is structurally similar to PP2A (SMAP) but biologically inactive. TRC-766 lacks a key N-H sulfonamide hydrogen bond donor. While TRC-766 still binds PP2A, it does not activate the phosphatase and therefore it was postulated to not affect cell viability[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

524.98

Formula

C25H24ClF3N2O3S

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC=C(OC(F)(F)F)C=C1)(N(CCCN2C3=CC(Cl)=CC=C3CCC4=CC=CC=C42)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 150 mg/mL (285.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9048 mL 9.5242 mL 19.0483 mL
5 mM 0.3810 mL 1.9048 mL 3.8097 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9048 mL 9.5242 mL 19.0483 mL 47.6209 mL
5 mM 0.3810 mL 1.9048 mL 3.8097 mL 9.5242 mL
10 mM 0.1905 mL 0.9524 mL 1.9048 mL 4.7621 mL
15 mM 0.1270 mL 0.6349 mL 1.2699 mL 3.1747 mL
20 mM 0.0952 mL 0.4762 mL 0.9524 mL 2.3810 mL
25 mM 0.0762 mL 0.3810 mL 0.7619 mL 1.9048 mL
30 mM 0.0635 mL 0.3175 mL 0.6349 mL 1.5874 mL
40 mM 0.0476 mL 0.2381 mL 0.4762 mL 1.1905 mL
50 mM 0.0381 mL 0.1905 mL 0.3810 mL 0.9524 mL
60 mM 0.0317 mL 0.1587 mL 0.3175 mL 0.7937 mL
80 mM 0.0238 mL 0.1191 mL 0.2381 mL 0.5953 mL
100 mM 0.0190 mL 0.0952 mL 0.1905 mL 0.4762 mL
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TRC-766 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
TRC-766
Cat. No.:
HY-131443
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