2. Apoptosis
  3. Apoptosis
  4. Triphen diol

Triphen diol is a phenol diol derivative, which has excellent anticancer activity against pancreatic cancer and cholangiocarcinoma, and can induce pancreatic cell apoptosis through two mechanisms, caspase-mediated and caspase-independent.

For research use only. We do not sell to patients.

Triphen diol Chemical Structure

Triphen diol Chemical Structure

CAS No. : 1213777-80-0

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Triphen diol Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Triphen diol is a phenol diol derivative, which has excellent anticancer activity against pancreatic cancer and cholangiocarcinoma, and can induce pancreatic cell apoptosis through two mechanisms, caspase-mediated and caspase-independent[1].
In Vitro

Triphen diol (0-10 μM, 48-120 h) can inhibit the proliferation of pancreatic cells and induce apoptosis, with an IC50 value of 8 μM for HPAC and PANC-1 cells and an IC50 value of 0.8 for MIAPaCa-2 cells μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Triphen diol Related Antibodies

Apoptosis Analysis[1]

Cell Line: Human pancreatic cell lines HPAC, MIAPaCa-2, and PANC-1
Concentration: 10 μM
Incubation Time: 48 h
Result: Induced caspase-dependent apoptosis in MIAPaCa-2 and PANC-1 cells, 60% of the cells were in the early stage of apoptosis, and 30% of the cells were in the late stage of apoptosis.
Reduced Bcl-2 levels in MIAPaCa-2 and HPAC cell lines.
In Vivo

Triphen diol (50 mg/kg, oral gavage, daily, 15 days) can significantly inhibit tumor proliferation in male Balb/c nude mice transplanted with MIAPaCa2 cell line, and can be combined with gemcitabine to show better efficacy[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

348.39

Formula

C22H20O4
CAS No.
SMILES

OC1=CC=C2C(OC[C@H](C3=CC=C(O)C=C3)[C@@H]2C4=CC=C(OC)C=C4)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Triphen diol Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Triphen diol1213777-80-0ApoptosisanticancerpancreaticcholangiocarcinomaapoptosiscaspaseInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Triphen diol
Cat. No.:
HY-14570
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.