2. GPCR/G Protein Neuronal Signaling
  3. Somatostatin Receptor
  4. TT-232

TT-232  (Synonyms: CAP-232; TLN-232)

Cat. No.: HY-105172 Purity: 98.96%
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TT-232 (CAP-232), a somatostatin derivative, is a peptide SSTR1/SSTR4 agonist. TT-232 inhibits cancer cell proliferation and induces apoptosis. TT-232 is also a broad-spectrum anti-inflammatory and analgesic agent.

For research use only. We do not sell to patients.

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TT-232 Chemical Structure

TT-232 Chemical Structure

CAS No. : 147159-51-1

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Based on 1 publication(s) in Google Scholar

TT-232 Related Antibodies

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Description

TT-232 (CAP-232), a somatostatin derivative, is a peptide SSTR1/SSTR4 agonist. TT-232 inhibits cancer cell proliferation and induces apoptosis. TT-232 is also a broad-spectrum anti-inflammatory and analgesic agent[1][2][4].

IC50 & Target[4]

SSTR1

 

SSTR4

 

In Vitro

TT-232 (10 μg/mL, 48 h) induces apoptosis in human colon (HT-29 and SW620), pancreatic (818), leukemia (K-562), melanoma (WM 938/B, M-1 and EP) and lymphoma (HT-58) tumor cell lines[1].
TT-232 (20-30 μg/mL, 24 h) shows antiproliferative effect on various human tumor cell lines[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TT-232 Related Antibodies

Cell Viability Assay[2]

Cell Line: MCF7, PC-3, P818, K-562, 4-1ST, ect.
Concentration: 20-30 μg/mL
Incubation Time: 24 h
Result: Inhibited cell proliferation by 87%, 90%, 98%, 95%, respectively.
In Vivo

TT-232 (15-750 μg/kg/day, twice a day) inhibits tumor growth in mice transplanted with Colon 26 cell[2].
TT-232 (0.6 or 15 μg/kg s.c or i.p.) shows antitumor effect on P-388 rodent lymphocytic leukemia tumor mice[3].
TT-232 (7.5-20 μg/kg, i.v.) inhibits Carrageenin-induced paw oedema in rats[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice transplanted with Colon 26 cell [2].
Dosage: 15, 150, 750 μg/kg/day
Administration: Intraperitoneal injection (i.p.)
Result: Reached 70% tumor inhibition at 750 μg/kg.
Clinical Trial
Molecular Weight

947.13

Formula

C45H58N10O9S2
CAS No.
Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : < 0.1 mg/mL (insoluble)

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
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TT-232 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TT-232147159-51-1CAP-232 TLN-232TT232TT 232CAP232CAP 232TLN232TLN 232TLN-232Somatostatin ReceptorSSTRsSSTRAntitumorsomatostatinleukemiacancerColon 26P-388oedemaInhibitorinhibitorinhibit

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