2. Anti-infection
  3. Parasite
  4. UCB7362

UCB7362 is an orally active and potent antimalarial plasmepsin X (PMX) inhibitor, with an IC50 of 7 nM. UCB7362 inhibits parasite growth.

For research use only. We do not sell to patients.

UCB7362 Chemical Structure

UCB7362 Chemical Structure

CAS No. : 3031484-59-7

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UCB7362 Related Antibodies

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Description

UCB7362 is an orally active and potent antimalarial plasmepsin X (PMX) inhibitor, with an IC50 of 7 nM. UCB7362 inhibits parasite growth[1].

IC50 & Target

Plasmodium

 

In Vitro

UCB7362 is substantially more potent against PMX than PMIX with an IC50 of 7 nM for the former compared to 142 nM for the latter[1].
UCB7362 also demonstrates an improvement in selectivity against Cat D and Renin with an IC50 of 3889 nM and >10,000 nM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

UCB7362 Related Antibodies
In Vivo

UCB7362 (10-60 mg/kg, Oral administration, twice a day, for 4 days) clears parasitemia from peripheral blood[1].
UCB7362 (IV (1 mg/kg), PO (10 mg/kg); once) shows moderate clearance in dog and cynomolgus monkey and moderate-high in rat[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pf (Plasmodium falciparum) SCID mouse model[1]
Dosage: 10, 25 and 60 mg/kg
Administration: Oral administration, twice a day, for 4 days, with the second administration 10 h after the first one
Result: Cleared parasitemia from peripheral blood in a dose-dependent manner.
Animal Model: Sprague Dawley rat[1]
Dosage: 1 mg/kg, 10 mg/kg
Administration: IV (1 mg/kg), PO (10 mg/kg); once (Pharmacokinetic Analysis)
Result: Pharmacokinetic Parameters of UCB7362 in Sprague-Dawley rats[1].
IV (1 mg/kg) PO (10 mg/kg)
CL (mL/(min kg)) 43.9
Vss (L/kg) 5.72
Tmax (h) 3
Cmax (nM) 246
AUC0-24 (nM∗h) 793 1410
t1/2 (h) 2.1
F (%) 11
Molecular Weight

479.96

Formula

C25H26ClN5O3
CAS No.
SMILES

O=C(NC1=CC=CC([C@@](CC(N2[C@@H]3C[C@H](C)OCC3)=O)(C)NC2=N)=C1Cl)C4=CC=CC(C#N)=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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UCB7362 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UCB73623031484-59-7UCB 7362UCB-7362ParasiteantimalarialPlasmodium falciparumorally activemalarialInhibitorinhibitorinhibit

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HY-151568
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