2. Natural Products
  3. Disease Research Fields Plants Alkaloids
  4. Acanthaceae Neurological Disease other families Pyrrole Alkaloids
  5. Adhatoda vasica Nees
  6. Vasicinone

Vasicinone  (Synonyms: (-)-Vasicinone)

Cat. No.: HY-N1100 Purity: 99.83%
COA Handling Instructions

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Vasicinone is a quinazoline alkaloid isolated from the Adhatoda vasica. Vasicinone is a potential agent for Parkinson's disease and possibly other oxidative stress-related neurodegenerative disorders.

For research use only. We do not sell to patients.

Vasicinone Chemical Structure

Vasicinone Chemical Structure

CAS No. : 486-64-6

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1 mg USD 130 In-stock
5 mg USD 390 In-stock
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Based on 1 publication(s) in Google Scholar

Vasicinone Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Vasicinone is a quinazoline alkaloid isolated from the Adhatoda vasica. Vasicinone is a potential agent for Parkinson's disease and possibly other oxidative stress-related neurodegenerative disorders[1].

In Vitro

Vasicinone (1~30 µM; 24 hours; SH-SY5Y cells) significantly reverses the paraquat-induced reduction in cell viability[1].
Vasicinone (10 and 15 μM; 24 hours; SH-SY5Y cells) abates the paraquat-induced injury of SH-SY5Y cells by suppressing the MAPK signaling pathway, dose-dependently reduces the percentage of apoptotic cells and is capable of rescuing paraquat-induced apoptotic death[1].
Vasicinone (10 and 15 μM; SH-SY5Y cells) attenuates the paraquat-induced accumulation of reactive oxygen species (ROS) and attenuates the paraquat-induced expression of apoptotic proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Vasicinone Related Antibodies

Cell Viability Assay[1]

Cell Line: SH-SY5Y cells
Concentration: 1~30 µM
Incubation Time: 24 hours
Result: Significantly reversed the paraquat-induced reduction in cell viability.

Western Blot Analysis[1]

Cell Line: SH-SY5Y cells
Concentration: 10 and 15 µM
Incubation Time: 24 hours
Result: Abated the paraquat-induced injury of SH-SY5Y cells by suppressing the MAPK signaling pathway.

Apoptosis Analysis[1]

Cell Line: SH-SY5Y cells
Concentration: 10 and 15 µM
Incubation Time: 24 hours
Result: Dose-dependently reduced the percentage of apoptotic cells.
Molecular Weight

202.21

Formula

C11H10N2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N2C([C@@H](O)CC2)=NC3=C1C=CC=C3
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (247.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.9454 mL 24.7268 mL 49.4535 mL
5 mM 0.9891 mL 4.9454 mL 9.8907 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.83%

COA (253 KB) HNMR (253 KB) LCMS (88 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.9454 mL 24.7268 mL 49.4535 mL 123.6338 mL
5 mM 0.9891 mL 4.9454 mL 9.8907 mL 24.7268 mL
10 mM 0.4945 mL 2.4727 mL 4.9454 mL 12.3634 mL
15 mM 0.3297 mL 1.6485 mL 3.2969 mL 8.2423 mL
20 mM 0.2473 mL 1.2363 mL 2.4727 mL 6.1817 mL
25 mM 0.1978 mL 0.9891 mL 1.9781 mL 4.9454 mL
30 mM 0.1648 mL 0.8242 mL 1.6485 mL 4.1211 mL
40 mM 0.1236 mL 0.6182 mL 1.2363 mL 3.0908 mL
50 mM 0.0989 mL 0.4945 mL 0.9891 mL 2.4727 mL
60 mM 0.0824 mL 0.4121 mL 0.8242 mL 2.0606 mL
80 mM 0.0618 mL 0.3091 mL 0.6182 mL 1.5454 mL
100 mM 0.0495 mL 0.2473 mL 0.4945 mL 1.2363 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vasicinone486-64-6(-)-VasicinoneOthersquinazolinealkaloidAdhatodavasicaplantParkinsonoxidativestressneurodegenerativedisordersInhibitorinhibitorinhibit

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