2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. VU6004256

VU6004256 is a potent and selective M1 muscarinic positive allosteric modulator (PAM) with an EC50 value of 155 nM. VU6004256 has the potential for the research of schizophrenia.

For research use only. We do not sell to patients.

VU6004256 Chemical Structure

VU6004256 Chemical Structure

CAS No. : 2011034-33-4

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Description

VU6004256 is a potent and selective M1 muscarinic positive allosteric modulator (PAM) with an EC50 value of 155 nM. VU6004256 has the potential for the research of schizophrenia[1].

IC50 & Target[1]

mAChR1

155 nM (EC50)

In Vivo

VU6004256 (10 mg/kg; i.p.) attenuates excessive pyramidal cell firing in the prefrontal cortex of NR1 KD mice[1].
VU6004256 (3, 10 mg/kg; i.p.) reverses the performance impairments in novel object recognition and cue-mediated fear conditioning tasks and reduces hyper locomotor activity in NR1 KD mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male NR1 KD mice[1]
Dosage: 10 mg/kg
Administration: I.p.
Result: Showed no effect on pyramidal cell firing rate in WT littermate controls, significantly reduced pyramidal cell firing rate in NR1 KD mice.
Animal Model: Wild-type and NR1 KD mice[1]
Dosage: 3, 10 mg/kg
Administration: I.p.
Result: Dose-dependently reduced locomotor activity in NR1 KD, but not in WT mice, resulted in dose-dependent increases in recognition index in WT and NR1 KD mice; improved performance on test day in cue-mediated conditioned freezing in NR1 KD but not WT mice.
Molecular Weight

465.50

Formula

C25H25F2N5O2
CAS No.
SMILES

O=C(C1=CN(CC2=CC=C(C3=CN(C)N=C3)N=C2)C4=C1C(F)=CC(F)=C4)N[C@@H]5[C@@H](O)CCCC5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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VU6004256 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VU60042562011034-33-4VU 6004256VU-6004256mAChRMuscarinic acetylcholine receptorschizophreniaNR1 KD micenovel object recognitioncue-mediated fearhyper locomotor activityInhibitorinhibitorinhibit

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