α-Methyltyrosine methyl ester hydrochloride

Name: α-Methyltyrosine methyl ester hydrochloride
Brand: MedChemExpress
SKU: HY-W013407
Rating: 4.5 (1 reviews)

Cat. No.: HY-W013407 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

α-Methyltyrosine methyl ester hydrochloride is a competitive tyrosine hydroxylase inhibitor that inhibits the conversion of tyrosine to dopamine. α-Methyltyrosine methyl ester hydrochloride can be used as a tool for sympathetic nervous system research.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

α-Methyltyrosine methyl ester hydrochloride Chemical Structure

CAS No. : 7361-31-1

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
25 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 130	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

Molecular Weight

245.70

Formula

C₁₁H₁₆ClNO₃

CAS No.

7361-31-1

Appearance

Solid

Color

White to light yellow

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 25 mg/mL (101.75 mM; Need ultrasonic)

DMSO : 9.09 mg/mL (37.00 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.0700 mL	20.3500 mL	40.7000 mL
5 mM	0.8140 mL	4.0700 mL	8.1400 mL
10 mM	0.4070 mL	2.0350 mL	4.0700 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 0.91 mg/mL (3.70 mM); Clear solution

This protocol yields a clear solution of ≥ 0.91 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (9.1 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 0.91 mg/mL (3.70 mM); Clear solution

This protocol yields a clear solution of ≥ 0.91 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (9.1 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 0.91 mg/mL (3.70 mM); Clear solution

This protocol yields a clear solution of ≥ 0.91 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (9.1 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (271 KB) SDS (0 KB)

COA (247 KB) HNMR (112 KB)

Handling Instructions (2659 KB)

References

[1]. G Magnusson, et al. Renal lesions induced by alpha-methyltyrosine methylester and alpha-methyltyrosine. Acta Pharmacol Toxicol (Copenh). 1970;28(6):435-44. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	4.0700 mL	20.3500 mL	40.7000 mL	101.7501 mL
	5 mM	0.8140 mL	4.0700 mL	8.1400 mL	20.3500 mL
	10 mM	0.4070 mL	2.0350 mL	4.0700 mL	10.1750 mL
	15 mM	0.2713 mL	1.3567 mL	2.7133 mL	6.7833 mL
	20 mM	0.2035 mL	1.0175 mL	2.0350 mL	5.0875 mL
	25 mM	0.1628 mL	0.8140 mL	1.6280 mL	4.0700 mL
	30 mM	0.1357 mL	0.6783 mL	1.3567 mL	3.3917 mL
H₂O	40 mM	0.1018 mL	0.5088 mL	1.0175 mL	2.5438 mL
	50 mM	0.0814 mL	0.4070 mL	0.8140 mL	2.0350 mL
	60 mM	0.0678 mL	0.3392 mL	0.6783 mL	1.6958 mL
	80 mM	0.0509 mL	0.2544 mL	0.5088 mL	1.2719 mL
	100 mM	0.0407 mL	0.2035 mL	0.4070 mL	1.0175 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Methyltyrosine methyl ester7361-31-1Otherstyrosine hydroxylase inhibitortyrosinedopaminenervous systemInhibitorinhibitorinhibit

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α-Methyltyrosine methyl ester hydrochloride

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