β-Sitosterol-d₇ (Mixture of Diastereomers)

Name: β-Sitosterol-d 7 (Mixture of Diastereomers)
Brand: MedChemExpress
SKU: HY-132382S
Rating: 5.0 (1 reviews)

Cat. No.: HY-132382S Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

β-Sitosterol-d₇ (Mixture of Diastereomers) is the deuterium labeled β-Sitosterol (mixture of diasteromers)[1].

For research use only. We do not sell to patients.

β-Sitosterol-d<sub>7</sub> (Mixture of Diastereomers) Chemical Structure

β-Sitosterol-d₇ (Mixture of Diastereomers) Chemical Structure

CAS No. : 2260669-28-9

Size	Price	Stock	Quantity
1 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 250	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

β-Sitosterol-d₇ (Mixture of Diastereomers) is the deuterium labeled β-Sitosterol (mixture of diasteromers)[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

421.75

Formula

C₂₉H₄₃D₇O

CAS No.

2260669-28-9

Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(CC)C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(C[C@H](CC4)O)=CC3)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

THF : 50 mg/mL (118.55 mM; Need ultrasonic)

Ethanol : 16.67 mg/mL (39.53 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3711 mL	11.8554 mL	23.7107 mL
5 mM	0.4742 mL	2.3711 mL	4.7421 mL
10 mM	0.2371 mL	1.1855 mL	2.3711 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% EtOH 90% Corn Oil
Solubility: ≥ 1 mg/mL (2.37 mM); Clear solution

This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (10.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (251 KB) HNMR (304 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Ethanol / THF	1 mM	2.3711 mL	11.8554 mL	23.7107 mL	59.2768 mL
	5 mM	0.4742 mL	2.3711 mL	4.7421 mL	11.8554 mL
	10 mM	0.2371 mL	1.1855 mL	2.3711 mL	5.9277 mL
	15 mM	0.1581 mL	0.7904 mL	1.5807 mL	3.9518 mL
	20 mM	0.1186 mL	0.5928 mL	1.1855 mL	2.9638 mL
	25 mM	0.0948 mL	0.4742 mL	0.9484 mL	2.3711 mL
	30 mM	0.0790 mL	0.3952 mL	0.7904 mL	1.9759 mL
THF	40 mM	0.0593 mL	0.2964 mL	0.5928 mL	1.4819 mL
	50 mM	0.0474 mL	0.2371 mL	0.4742 mL	1.1855 mL
	60 mM	0.0395 mL	0.1976 mL	0.3952 mL	0.9879 mL
	80 mM	0.0296 mL	0.1482 mL	0.2964 mL	0.7410 mL
	100 mM	0.0237 mL	0.1186 mL	0.2371 mL	0.5928 mL