1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor

SKF 38393 hydrochloride (Synonyms: (±)-SKF-38393 hydrochloride; SKF-38393)

Cat. No.: HY-12520A Purity: 99.49%
Data Sheet SDS Handling Instructions

SKF 38393 hydrochloride is a D1 agonist with IC50 of 110 nM.

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SKF 38393 hydrochloride Chemical Structure

SKF 38393 hydrochloride Chemical Structure

CAS No. : 62717-42-4

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Description

SKF 38393 hydrochloride is a D1 agonist with IC50 of 110 nM. IC50 value: 110 nM [1] Target: D1 agonist in vitroL SKF 38393 hydrochloride is a benzazepine selective agonist of the D1DR (dopamine D1 receptor). Agonism of the D1DR by SKF 38393 is correlated to induced desynchronization of electroencephalographic activity in rats. SKF 38393 is also reported to demonstrate agonism of the serotonin SR-2C (5-HT1C receptor). SKF 38393 HCl is an activator of D5DR. SKF 38393 is a synthetic compound of the benzazepine chemical class which acts as a selective D1/D5 receptor partial agonist. It has stimulant and anorectic effects. SKF-38393 enhances the frequency of mEPSCs in a concentration-dependent manner. SKF-38393 enhances the frequency of mEPSCs in a concentration-dependent manner. [2]

References
Molecular Weight

291.77

Formula

C₁₆H₁₈ClNO₂

CAS No.

62717-42-4

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 34 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
SKF 38393 hydrochloride
Cat. No.:
HY-12520A
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