1. Metabolic Enzyme/Protease
  2. 5-Lipoxygenase

5-Lipoxygenase

5-Lipoxygenase (5-LOX or 5-LO) is an enzyme that in humans is encoded by the ALOX5 gene. 5-lipoxygenase is a member of the lipoxygenase family of enzymes. It transforms EFAs into leukotrienes and is a current target for pharmaceutical intervention in a number of diseases. 5-LO catalyzes oxidation of AA at the 5-position to yield 5-HpETE. 5-LO then converts 5-HpETE to leukotriene A4. Recently, oxidized lipid products of 5-LO have been measured in membranes of neutrophils in the form of esterified-5-HETE phospholipids. These novel products have biological activities including inhibition of neutrophil extracellular traps. 5-LO is a target for pharmaceutical intervention in CAD. Some people with variant alleles for 5-LO are at elevated risk for CAD. 5-LO is expressed in brain cells and may participate in neuropathologic processes.

5-Lipoxygenase Related Products (15):

Cat. No. Product Name Effect Purity
  • HY-13419
    U-73122 Inhibitor >98.0%
    U-73122 is an inhibitor of phospholipase C (PLC), phospholipase A2, and 5-LO (5-lipoxygenase).
  • HY-14164
    Zileuton Inhibitor 99.84%
    Zileuton (A-64077) is a selective and potent 5-LO inhibitor, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation.
  • HY-12341
    ML355 Inhibitor 98.17%
    ML355 is a potent and selective inhibitors of 12-Lipoxygenase(12-LOX) with IC50 of 0.34 uM, excellent selectivity over related lipoxygenases and cyclooxygenases, and possess favorable ADME properties.
  • HY-14164A
    Zileuton sodium Inhibitor
    Zileuton (sodium) is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation.
  • HY-U00024
    Enazadrem Inhibitor
    Enazadrem is a 5-lipoxygenase inhibitor with antiinflammatory activities.
  • HY-U00260
    CMI977 Inhibitor
    CMI977 is a potent 5-Lipoxygenase (5-LO) inhibitor.
  • HY-U00156
    RS4317 Inhibitor
    RS4317 is a topically effective 5-lipoxygenase (5-LO) inhibitor.
  • HY-19205A
    CMI-392 Inhibitor
    CMI-392 is a dual 5-lipoxygenese inhibitor and platelet-activating factor (PAF) receptor antagonist with IC50s of 100 and 10 nM, respectively.
  • HY-A0060
    Malotilate Inhibitor
    Malotilate is a liver protein metabolism improved compound, which selectively inhibit the 5-lipoxygenase.
  • HY-101579
    LY 178002 Antagonist
    LY 178002 is a potent inhibitor of cyclooxygenase, 5-1ipoxygenase, phospholipase A2 and cellular production of LTB4 by human polymorphonuclear leukocytes, with IC50 of 0.6 μM for 5-1ipoxygenase.
  • HY-U00022
    RWJ 63556 Inhibitor
    RWJ 63556 is an orally active COX-2 selective/5-lipoxygenase inhibitor, with anti-inflammatory activities.
  • HY-19212
    S-2474 Inhibitor
    S-2474 is an inhibitor of COX-2 and 5-lipoxygenase, and used as a nonsteroidal anti-inflammatory drug.
  • HY-U00170
    U66858 Inhibitor
    U66858 is a potent inhibitor of LTB4 production in human whole blood.
  • HY-101587
    PGS-IN-1 Inhibitor
    PGS-IN-1 is a potent inhibitor of prostaglandin synthetase (PGS) with an IC50 of 0.28 μM; also inhibits 5-lipoxygenase with an IC50 of 1.05 μM.
  • HY-N2176
    S-(+)-Marmesin Inhibitor
    S-(+)-Marmesin is a natural coumarin, exhibiting COX-2/5-LOX dual inhibitory activity.