1. Metabolic Enzyme/Protease
  2. 5-Lipoxygenase

5-Lipoxygenase

5-Lipoxygenase (5-LOX or 5-LO) is an enzyme that in humans is encoded by the ALOX5 gene. 5-lipoxygenase is a member of the lipoxygenase family of enzymes. It transforms EFAs into leukotrienes and is a current target for pharmaceutical intervention in a number of diseases. 5-LO catalyzes oxidation of AA at the 5-position to yield 5-HpETE. 5-LO then converts 5-HpETE to leukotriene A4. Recently, oxidized lipid products of 5-LO have been measured in membranes of neutrophils in the form of esterified-5-HETE phospholipids. These novel products have biological activities including inhibition of neutrophil extracellular traps. 5-LO is a target for pharmaceutical intervention in CAD. Some people with variant alleles for 5-LO are at elevated risk for CAD. 5-LO is expressed in brain cells and may participate in neuropathologic processes.

5-Lipoxygenase Related Products (5):

Cat. No. Product Name Effect Purity
  • HY-13419
    U-73122 Inhibitor >98.0%
    U-73122 is an inhibitor of phospholipase C (PLC), phospholipase A2, and 5-LO (5-lipoxygenase).
  • HY-14164
    Zileuton Inhibitor 99.84%
    Zileuton (A-64077) is a selective and potent 5-LO inhibitor, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation.
  • HY-12341
    ML355 Inhibitor 98.17%
    ML355 is a potent and selective inhibitors of 12-Lipoxygenase(12-LOX) with IC50 of 0.34 uM, excellent selectivity over related lipoxygenases and cyclooxygenases, and possess favorable ADME properties.
  • HY-14164A
    Zileuton sodium Inhibitor
    Zileuton (sodium) is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation.
  • HY-A0060
    Malotilate Inhibitor
    Malotilate is a liver protein metabolism improved compound, which selectively inhibit the 5-lipoxygenase.