1. Metabolic Enzyme/Protease
  2. Cytochrome P450

Cytochrome P450

Cytochrome p450 comprises a superfamily of heme-thiolate proteins named for the spectral absorbance peak of their carbon-monoxide-bound species at 450 nm. Having been found in every class of organism, including Archaea, the p450 superfamily is believed to have originated from an ancestral gene that existed over 3 billion years ago. Repeated gene duplications have subsequently given rise to one of the largest of multigene families. These enzymes are notable both for the diversity of reactions that they catalyze and the range of chemically dissimilar substrates upon which they act. Cytochrome p450s support the oxidative, peroxidative and reductive metabolism of such endogenous and xenobiotic substrates as environmental pollutants, agrochemicals, plant allelochemicals, steroids, prostaglandins and fatty acids. In humans, Cytochrome p450s are best known for their central role in phase I drug metabolism where they are of critical importance to two of the most significant problems in clinical pharmacology: drug interactions and interindividual variability in drug metabolism.

Cytochrome P450 Related Products (34):

Cat. No. Product Name Effect Purity
  • HY-14531
    Talarozole Inhibitor
    Talarozole is a potent inhibitor of both CYP26A1 and CYP26B1, with IC50 of 0.46 nM and 5.1 nM for CYP26B1 and CYP26A1, respectively.
  • HY-75054
    Abiraterone acetate Inhibitor
    Abiraterone acetate is an oral, potent, selective, and irreversible inhibitor of CYP17.
  • HY-70013
    Abiraterone Inhibitor
    Abiraterone is a potent, selective, and irreversible CYP17 inhibitor with IC50 of 2 to 4 nM.
  • HY-10493
    Cobicistat Inhibitor
    Cobicistat is a potent, and selective inhibitor of cytochrome P450 3A (CYP3A) enzymes with IC50 of 30-285 nM.
  • HY-12451
    FICZ
    FICZ is a potent aryl hydrocarbon receptor (AHR) agonist, and also has the qualities of a perfect substrate for mammalian CYP1 enzymes.
  • HY-N0779
    Isosilybin Inhibitor
    Isosilybin (Isosilybinin) is a flavonoid from milk thistle; inhibits CYP3A4 induction with an IC50 of 74 μM.
  • HY-N0125
    Diosmetin Inhibitor
    Diosmetin is a natural flavonoid which inhibits human CYP1A enzyme activity with an IC50 of 40 μM in HepG2 cell.
  • HY-17356
    Fenofibrate Inhibitor
    Fenofibrate is a relatively potent inhibitor of CYP2C19 (IC50=0.2 μM) and CYP2B6 (IC50=0.7 μM). Fenofibrate is also a well-known PPARα agonist (EC50=30 μM).
  • HY-70006
    TOK-001 Inhibitor
    TOK-001 is a multifunctional antiandrogen and CYP17 inhibitor (IC50=47 nM) in castration resistant prostate cancer (CRPC).
  • HY-B0105
    Ketoconazole Inhibitor
    Ketoconazole is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.
  • HY-17508
    Clarithromycin Inhibitor
    Clarithromycin is a macrolide antibiotic and a CYP3A4 inhibitor.
  • HY-B0365A
    Memantine hydrochloride Inhibitor
    Memantine, an amantadine derivative with low to moderate-affinity for NMDA receptors, inhibit CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively.
  • HY-15996
    VT-464 Inhibitor
    VT-464 is a potent CYP17 lyase inhibitor(h-Lyase IC50=69 nM) that demonstrated both exceptional in vitro lyase/hydroxylase selectivity (~10-fold) and oral activity in a hamster model of androgen biosynthesis inhibition.
  • HY-10505
    Orteronel Inhibitor
    Orteronel is a highly selective inhibitor of human 17,20-lyase with IC50 of 38 nM, and exhibits >1000-fold selectivity over other CYPs such as 11-hydroxylase and CYP3A4.
  • HY-76316
    Bergaptol Inhibitor
    Bergaptol A hydroxylated psoralen that acts as a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 uM. Recent studies suggest that it may have antiproliferative and anticancer properties.
  • HY-30151
    Methoxsalen Inhibitor
    Methoxsalen (8-Methoxypsoralen) is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight.
  • HY-N0370
    Bergapten Inhibitor
    Bergapten is a natural anti-inflammatory and anti-tumor agent isolated from bergamot essential oil, other citrus essential oils and grapefruit juice. 5-Methoxypsoralen is inhibitory towards mouse and human CYP isoforms.
  • HY-N0153
    Naringin Inhibitor
    Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities.
  • HY-N0382
    Galangin Inhibitor
    Galangin is an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity.
  • HY-B0105A
    (+)-Ketoconazole Inhibitor
    (+)-Ketoconazole is an imidazole anti-fungal agent, a CYP3A4 inhibitor.