1. GPCR/G Protein
  2. GHSR

GHSR

GHSR (Growth hormone secretagogue receptor) is a member of the G-protein coupled receptor family. GHSR may play a role in energy homeostasis and regulation of body weight. The pathway activated by binding of ghrelin to the growth hormone secretagogue receptor, GHSR1a, regulates the activation of the downstream mitogen-activated protein kinase, Akt, nitric oxide synthase, and AMPK cascades in different cellular systems. One of the important features of GHSR1a displays constitutive activity possessing basal activity in the absence of an agonist, resulting in a high degree of receptor internalization as well as of signaling activity. Inverse agonists for the ghrelin receptor could be particularly interesting for the treatment of obesity. A range of selective ligands for the GHSR receptor are now available and are being developed for several clinical applications. GHSR agonists have appetite-stimulating and growth hormone-releasing effects, and are likely to be useful for the treatment of muscle wasting and frailty associated with old-age and degenerative diseases. On the other hand, GHSR antagonists have anorectic effects and are likely to be useful for the treatment of obesity.

GHSR Related Products (7):

Cat. No. Product Name Effect Purity
  • HY-14734
    Anamorelin Agonist
    Anamorelin is a novel ghrelin receptor agonist with EC50 value of 0.74 nM in the FLIPR assay.
  • HY-50844
    Ibutamoren Mesylate Agonist
    Ibutamoren (Mesylate) is a potent, non-peptide Growth hormone secretagogue receptor (GHSR) agonist.
  • HY-P0166
    Alexamorelin Inhibitor
    Alexamorelin is a new synthetic heptapeptide which inhibits GHS binding in vitro.
  • HY-P0166A
    Alexamorelin Met 1 Inhibitor
    Alexamorelin Met 1 is one of the metabolites of alexamorelin. The heptapeptide Ala-His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2 (Alexamorelin) is a synthetic molecule which inhibits growth hormone secretagogue binding in vitro.
  • HY-P0169A
    GHRP-2 metabolite 1 Agonist
    GHRP-2 metabolite 1 is one of the GHRP-2 metabolites. Growth hormone releasing peptide -2 (GHRP-2), a peptide with six amino acid units (D-Ala-D-beta- + Nal-Ala-Trp-D-Phe-Lys-NH2), is a synthetic agonist of ghrelin. GHRP-2 can significantly promote the release of growth hormone, improving the blood growth hormone concentration in animals and humans.
  • HY-14734A
    Anamorelin hydrochloride Agonist
    Anamorelin Hcl(RC1291; ONO-7643) is a synthetic orally active ghrelin receptor agonist which is under development for the management of non-small lung cancer associated cachexia/anorexia.
  • HY-14734B
    Anamorelin Fumarate Agonist
    Anamorelin fumarate(RC1291; ONO-7643) is a synthetic orally active ghrelin receptor agonist which is under development for the management of non-small lung cancer associated cachexia/anorexia.