1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR

nAChR

nAChRs (nicotinic acetylcholine receptors) are neuron receptor proteins that signal for muscular contraction upon a chemical stimulus. They are cholinergic receptors that form ligand-gated ion channels in the plasma membranes of certain neurons and on the presynaptic and postsynaptic sides of theneuromuscular junction. Nicotinic acetylcholine receptors are the best-studied of the ionotropic receptors. Like the other type of acetylcholine receptor-the muscarinic acetylcholine receptor (mAChR)-the nAChR is triggered by the binding of the neurotransmitter acetylcholine (ACh). Just as muscarinic receptors are named such because they are also activated by muscarine, nicotinic receptors can be opened not only by acetylcholine but also by nicotine —hence the name "nicotinic".

nAChR Related Products (31):

Cat. No. Product Name Effect Purity
  • HY-17418
    Vinblastine Inhibitor
    Vinblastine is a cytotoxic alkaloid used against various cancer types. Vinblastine inhibits the formation of microtubule and suppresses nAChR with an IC50 of 8.9 μM.
  • HY-B0638
    L-Nicotine Agonist
    L-Nicotine is the prototype of nicotinic acetylcholine receptor agonists; natural isomer.
  • HY-12560A
    PNU-282987 Agonist
    PNU-282987 is a selective α7 nicotinic acetylcholine receptor(α7 nAChR) agonist with Ki of 26 nM; no affinity for α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM).
  • HY-12152
    PNU-120596 Agonist
    PNU-120596 (NSC 216666 ) is a potent and selective positive allosteric α7 nAChR modulator with an EC50 of 0.2 μM.
  • HY-B0429
    Pancuronium dibromide Antagonist
    Pancuronium Dibromide is a bis-quaternary steroid that is a competitive nicotinic antagonist.
  • HY-12560D
    PNU-282987 S enantiomer free base
    PNU-282987 S enantiomer free base is the S-enantiomer of PNU-282987 free base. PNU-282987 is anα7 nicotinic acetylcholine receptor(α7 nAChR) agonist.
  • HY-14774
    Monepantel Agonist
    Monepantel is organic anthelmintic, and acts as a positive allosteric modulator of a nematode-specific clade of nicotinic acetylcholine receptor (nAChR) subunits.
  • HY-11013
    ZSET1446 Agonist
    ZSET1446 is a novel cognitive enhancer that significantly improves learning deficits in various types of Alzheimer disease (AD) models.
  • HY-15430A
    EVP-6124 hydrochloride Agonist
    EVP-6124 hydrochloride is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs).
  • HY-14564A
    GTS-21 dihydrochloride Agonist
    GTS-21 dihydrochloride is a selective α7 nicotinic acetylcholine receptor agonist, has recently been established as a promising treatment for inflammation.
  • HY-B0118A
    Vecuronium bromide Inhibitor
    Vecuronium (bromide) is a muscle relaxant in the category of non-depolarizing blocking agents.
  • HY-10932
    Aniracetam Modulator
    Aniracetam(Ro 13-5057) is a nootropics and neuroprotective drug, which is selectively modulates the AMPA receptor and nAChR.
  • HY-B1208
    Carbamoylcholine chloride Agonist
    Carbamoylcholine chloride is used to study responses mediated by nAChR and mAChR, including smooth muscle contraction, gut motility, and neuronal signaling.
  • HY-N0252
    Catharanthine Inhibitor
    Catharanthine inhibits nicotinic receptor mediated diaphragm contractions with IC50 of 59.6 μM.
  • HY-B0827
    Dinotefuran Inhibitor
    Dinotefuran is an insecticide of the neonicotinoid class, its mechanism of action involves disruption of the insect's nervous system by inhibiting nicotinic acetylcholine receptors.
  • HY-13596
    Cisatracurium besylate Antagonist
    Cisatracurium Besylate is a nondepolarizing neuromuscular blocking agent, antagonizing the action of acetylcholine by inhibiting neuromuscular transmission.
  • HY-B0569
    Hexamethonium Bromide Antagonist
    Hexamethonium is a non-depolarising ganglionic blocker, a nicotinic nACh (NN) receptor antagonist.
  • HY-B0379A
    Adiphenine hydrochloride Inhibitor
    Adiphenine HCl is a nicotinic receptor inhibitor, used as an antispasmodic drug.
  • HY-12149
    A-867744 Agonist
    A-867744 is a positive allosteric modulator of α7 nAChRs (IC50 values are 0.98 and 1.12 μM for human and rat α7 receptor ACh-evoked currents respectively, in X.
  • HY-13225A
    RJR-2403 Agonist
    RJR-2403(Metanicotine; Rivanicline) is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki=26 nM); > 1,000 fold selectivity than α7 receptors(Ki= 36000 nM).