2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Apoptosis
  3. HSP Apoptosis
  4. CCT018159

CCT018159, a 3,4-diaryl pyrazoleresorcinol, is a ATP-competitive HSP90 ATPase activity inhibitor with IC50s of 3.2 and 6.6 µM for human Hsp90β and yeast Hsp90, respectively. CCT018159 caused cell cytostasis associated with a G1 arrest and induces apoptosis. CCT018159 inhibits key endothelial and tumor cell functions implicated in invasion and angiogenesis.

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CCT018159 Chemical Structure

CCT018159 Chemical Structure

CAS No. : 171009-07-7

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5 mg USD 90 In-stock
10 mg USD 140 In-stock
25 mg USD 280 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

CCT018159, a 3,4-diaryl pyrazoleresorcinol, is a ATP-competitive HSP90 ATPase activity inhibitor with IC50s of 3.2 and 6.6 µM for human Hsp90β and yeast Hsp90, respectively. CCT018159 caused cell cytostasis associated with a G1 arrest and induces apoptosis. CCT018159 inhibits key endothelial and tumor cell functions implicated in invasion and angiogenesis[1].

IC50 & Target[1]

human Hsp90β

3.2 μM (IC50)

yeast Hsp90

6.6 μM (IC50)

Molecular Weight

352.38

Formula

C20H20N2O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=C(C2=CC3=C(OCCO3)C=C2)C(C4=CC(CC)=C(O)C=C4O)=NN1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (354.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8378 mL 14.1892 mL 28.3785 mL
5 mM 0.5676 mL 2.8378 mL 5.6757 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.94%

COA (259 KB) HNMR (264 KB) LCMS (92 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8378 mL 14.1892 mL 28.3785 mL 70.9461 mL
5 mM 0.5676 mL 2.8378 mL 5.6757 mL 14.1892 mL
10 mM 0.2838 mL 1.4189 mL 2.8378 mL 7.0946 mL
15 mM 0.1892 mL 0.9459 mL 1.8919 mL 4.7297 mL
20 mM 0.1419 mL 0.7095 mL 1.4189 mL 3.5473 mL
25 mM 0.1135 mL 0.5676 mL 1.1351 mL 2.8378 mL
30 mM 0.0946 mL 0.4730 mL 0.9459 mL 2.3649 mL
40 mM 0.0709 mL 0.3547 mL 0.7095 mL 1.7737 mL
50 mM 0.0568 mL 0.2838 mL 0.5676 mL 1.4189 mL
60 mM 0.0473 mL 0.2365 mL 0.4730 mL 1.1824 mL
80 mM 0.0355 mL 0.1774 mL 0.3547 mL 0.8868 mL
100 mM 0.0284 mL 0.1419 mL 0.2838 mL 0.7095 mL
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CCT018159 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CCT018159171009-07-7CCT 018159CCT-018159HSPApoptosisHeat shock proteins3,4-diaryl pyrazoleresorcinolATP-competitiveHSP90 ATPase activityHsp90βcytostasisG1 arrestendothelialinvasionangiogenesisInhibitorinhibitorinhibit

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