2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation Anti-infection
  3. Histamine Receptor Parasite
  4. Conessine

Conessine, a steroidal alkaloid, is a potent and selective histamine H3 receptor antagonist with Kis of 5.4, 6.0, 5.7 and 25 nM for human, dog, guinea pig, and rat H H3 receptor, respectively. Anti-malarial activity.

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Conessine Chemical Structure

Conessine Chemical Structure

CAS No. : 546-06-5

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Description

Conessine, a steroidal alkaloid, is a potent and selective histamine H3 receptor antagonist with Kis of 5.4, 6.0, 5.7 and 25 nM for human, dog, guinea pig, and rat H H3 receptor, respectively. Anti-malarial activity[1].

IC50 & Target[1]

Plasmodium

 

H3 Receptor

5.4 nM (Ki)

rat H3 receptor

25 nM (Ki)

Guinea pig H3 Receptor

6.0 nM (Ki)

Dog H3 Receptor

5.7 nM (Ki)

Molecular Weight

356.59

Formula

C24H40N2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@H]1[C@]2([H])[C@]3(CN1C)[C@](CC2)([H])[C@@]4([H])[C@]([C@@]5(C(C[C@H](CC5)N(C)C)=CC4)C)([H])CC3
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

Ethanol : 25 mg/mL (70.11 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8043 mL 14.0217 mL 28.0434 mL
5 mM 0.5609 mL 2.8043 mL 5.6087 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 2.8043 mL 14.0217 mL 28.0434 mL 70.1085 mL
5 mM 0.5609 mL 2.8043 mL 5.6087 mL 14.0217 mL
10 mM 0.2804 mL 1.4022 mL 2.8043 mL 7.0109 mL
15 mM 0.1870 mL 0.9348 mL 1.8696 mL 4.6739 mL
20 mM 0.1402 mL 0.7011 mL 1.4022 mL 3.5054 mL
25 mM 0.1122 mL 0.5609 mL 1.1217 mL 2.8043 mL
30 mM 0.0935 mL 0.4674 mL 0.9348 mL 2.3370 mL
40 mM 0.0701 mL 0.3505 mL 0.7011 mL 1.7527 mL
50 mM 0.0561 mL 0.2804 mL 0.5609 mL 1.4022 mL
60 mM 0.0467 mL 0.2337 mL 0.4674 mL 1.1685 mL
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Conessine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Conessine546-06-5Histamine ReceptorParasitehistamine H3 receptormalarialinfectionInhibitorinhibitorinhibit

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