2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Nuclear Factor of activated T Cells (NFAT) NF-κB Reactive Oxygen Species
  4. CPS-11

CPS-11  (Synonyms: N-(Hydroxymethyl)thalidomide)

Cat. No.: HY-117987 Purity: 99.39%
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CPS-11 (N-(Hydroxymethyl)thalidomide) a Thalidomide (HY-14658) analogue, is a potent anti-cancer agent. CPS-11 inhibits NF-κB, activates NFAT, and repress cytokine expression through elevated ROS. CPS-11 exhibits a wider activity spectrum and higher potency against MM (multiple myeloma) cell lines.

For research use only. We do not sell to patients.

CPS-11 Chemical Structure

CPS-11 Chemical Structure

CAS No. : 145945-21-7

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1 mg USD 500 In-stock
5 mg USD 1077 In-stock
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Based on 1 publication(s) in Google Scholar

CPS-11 Related Antibodies

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Description

CPS-11 (N-(Hydroxymethyl)thalidomide) a Thalidomide (HY-14658) analogue, is a potent anti-cancer agent. CPS-11 inhibits NF-κB, activates NFAT, and repress cytokine expression through elevated ROS. CPS-11 exhibits a wider activity spectrum and higher potency against MM (multiple myeloma) cell lines[1][2][3].

In Vitro

CPS-11 abrogates ability of bone marrow stromal cells (BMSCs) to induce proliferation of MM cells, confirming its ability to target tumor cells in the bone marrow microenvironment[1].
CPS-11 (0-200 μM, 0 or 4 h) shows virtually no effect on activation of p38 and only slight, transient activation of ATF2 and HSP27[2].
CPS-11 (0-100 μM, 24 or 48 h) was no toxic to H157 cells, WT MEFs or the p38α-/- MEFs at doses as high as 100 μM[2].
CPS-11 (50 μM, 24 or 48 h) does not induce apoptosis in H157 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CPS-11 Related Antibodies

Western Blot Analysis[2]

Cell Line: H157 cells, PC3 cells, HUVEC cells
Concentration: 0, 1, 5, 10, 20, 50, 100 and 200 μM
Incubation Time: 0, 15 min, 30 min, 1 h, 2 h, and 4 h
Result: Showed virtually no effect on activation of p38 and only slight, transient activation of ATF2 and HSP27. Increased Akt phosphorylation within 15 minutes, and decreased Akt phosphorylation from 15 minutes to 4 hours.

Cell Cytotoxicity Assay[2]

Cell Line: H157 cells, wild-type (WT) mouse embryonic fibroblasts (MEF) and p38α-/- MEF
Concentration: 0, 20, 50, and 100 μM
Incubation Time: 24 or 48 hours
Result: Showed no toxic to H157 cells at doses as high as 100 μM and an incubation time of 48 hours. had no toxic effect on either the WT MEFs or the p38α-/- MEFs at doses as high as 100 μM.

Apoptosis Analysis[2]

Cell Line: H157 cells
Concentration: 50 μM
Incubation Time: 24 or 48 hours
Result: Did not induce apoptosis in H157 cells at either time point.
Molecular Weight

288.26

Formula

C14H12N2O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(C(C2=C1C=CC=C2)=O)C(C(N3CO)=O)CCC3=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 57.7 mg/mL (200.17 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4691 mL 17.3455 mL 34.6909 mL
5 mM 0.6938 mL 3.4691 mL 6.9382 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4691 mL 17.3455 mL 34.6909 mL 86.7273 mL
5 mM 0.6938 mL 3.4691 mL 6.9382 mL 17.3455 mL
10 mM 0.3469 mL 1.7345 mL 3.4691 mL 8.6727 mL
15 mM 0.2313 mL 1.1564 mL 2.3127 mL 5.7818 mL
20 mM 0.1735 mL 0.8673 mL 1.7345 mL 4.3364 mL
25 mM 0.1388 mL 0.6938 mL 1.3876 mL 3.4691 mL
30 mM 0.1156 mL 0.5782 mL 1.1564 mL 2.8909 mL
40 mM 0.0867 mL 0.4336 mL 0.8673 mL 2.1682 mL
50 mM 0.0694 mL 0.3469 mL 0.6938 mL 1.7345 mL
60 mM 0.0578 mL 0.2891 mL 0.5782 mL 1.4455 mL
80 mM 0.0434 mL 0.2168 mL 0.4336 mL 1.0841 mL
100 mM 0.0347 mL 0.1735 mL 0.3469 mL 0.8673 mL
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CPS-11 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CPS-11145945-21-7N-(Hydroxymethyl)thalidomideCPS11CPS 11Nuclear Factor of activated T Cells (NFAT)NF-κBReactive Oxygen SpeciesNuclear factor-κBNuclear factor-kappaBH157 cellsPC3 cellsH1703 cellsmouse embryonic fibroblastsMEFp38bone marrow stromal cellsBMSCATF2HSP27Multiple MyelomaMMProstate cancerThalidomideInhibitorinhibitorinhibit

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