2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Apoptosis
  3. HSP Apoptosis
  4. CPUY201112

CPUY201112 is a potent heat shock protein Hsp90 inhibitor with Kd of 27 nM. CPUY201112 induces p53-mediated apoptosis in MCF-7 cells, resulting in cell cycle arrest, which can be used in cancer research.

For research use only. We do not sell to patients.

CPUY201112 Chemical Structure

CPUY201112 Chemical Structure

CAS No. : 1860793-58-3

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Description

CPUY201112 is a potent heat shock protein Hsp90 inhibitor with Kd of 27 nM. CPUY201112 induces p53-mediated apoptosis in MCF-7 cells, resulting in cell cycle arrest, which can be used in cancer research[1].

In Vitro

CPUY201112 (0-9 μM, 7 days) reduces the viability of multiple cancer cell lines such as HCT116 colon cells, HepG2 hepatocellular carcinoma and other cancer cells in a dose-dependent manner[1].
CPUY201112 (0-2 μM, 24 h) can induce apoptosis in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CPUY201112 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: HCT116, HepG2, MCF-7, A549
Concentration: 0-9 μM
Incubation Time: 7 days
Result: Inhibited MCF-7, A549, HCT116 and HepG2 cells with the IC50 values of 0.624, 0.543, 0.763 and 0.342 μM, respectively.

Apoptosis Analysis[1]

Cell Line: MCF-7 and HCT116 cells
Concentration: 0-2 μM
Incubation Time: 24 h
Result: Induced cell cycle arrest in G2/M phase and induced apoptosis in more than 35% of MCF-7 cells.
Induced p53-mediated apoptosis in HCT116 cells.
In Vivo

CPUY201112 (5-40 mg/kg, i.p., daily, 3 weeks) inhibits tumor growth in the MCF-7 tumor xenograft model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c nude mice with MCF-7 cell[1]
Dosage: 5 mg/kg, 20 mg/kg and 40 mg/kg
Administration: i.p., daily, 3 weeks
Result: Reduced tumor volume by 11.92%, 26.58% and 39.63%, respectively, when using 5 mg/kg, 20 mg/kg and 40 mg/kg.
Significantly induced the expression of Hsp70 and reduced the expression of Akt at 40 mg/kg.
Molecular Weight

357.40

Formula

C19H23N3O4
CAS No.
SMILES

O=C(N1CCC2=NC(OCC)=NC=C2C1)C3=CC(C(C)C)=C(C=C3O)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CPUY201112 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CPUY2011121860793-58-3CPUY 201112CPUY-201112HSPApoptosisHeat shock proteinsHsp90p53apoptosiscell cyclecancerInhibitorinhibitorinhibit

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