2. Anti-infection
  3. Virus Protease
  4. Dipotassium glycyrrhizinate

Dipotassium glycyrrhizinate  (Synonyms: Glycyrrhizic acid dipotassium; Dipotassium glycyrrhizate)

Cat. No.: HY-N0184A Purity: 99.51%
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Dipotassium glycyrrhizinate is a HMGB1 inhibitor, inhibits atopic dermatitis-related gene expression with anti-anti-inflammatory activity.

For research use only. We do not sell to patients.

Dipotassium glycyrrhizinate Chemical Structure

Dipotassium glycyrrhizinate Chemical Structure

CAS No. : 68797-35-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 55 In-stock
Solution
10 mM * 1 mL in Water USD 55 In-stock
Solid
50 mg USD 50 In-stock
100 mg USD 80 In-stock
500 mg USD 240 In-stock
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Based on 23 publication(s) in Google Scholar

Other Forms of Dipotassium glycyrrhizinate:

Dipotassium glycyrrhizinate Related Antibodies

Top Publications Citing Use of Products

    Dipotassium glycyrrhizinate purchased from MedChemExpress. Usage Cited in: Cell Prolif. 2020 Jun;53(6):e12829.  [Abstract]

    Protein levels of pro-caspase-1 + p10 + p12, GADMD, IL-1β, IL-18 and NLRP3 are detected by Western blotting. Glycyrrhizin inhibits pyroptosis in TNF-α-induced M1 macrophages.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Dipotassium glycyrrhizinate is a HMGB1 inhibitor, inhibits atopic dermatitis-related gene expression with anti-anti-inflammatory activity[1][2][3].

    In Vitro

    Dipotassium glycyrrhizinate (0-400 μM, 4 days) inhibits mRNA level of atopic dermatitis related genes (NELL2, CA2, AQP3, and HAS3 gene level) in IL‑4‑ and IL‑13‑induced keratinocytes[1].
    Dipotassium glycyrrhizinate (0-400 μM, 4 days) partially repaired the atopic dermatitis-like phenotype (the spongiosis like intercellular spaces) in the IL-4/IL-13-induced AD-like skin equivalent model[1].
    Dipotassium glycyrrhizinate (0-100 μM, 24 h) inhibits Sunitinib-induced autophagy, cardiomyocyte death in CCC-HEH-2 cells[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Dipotassium glycyrrhizinate Related Antibodies
    In Vivo

    Dipotassium glycyrrhizinate (150 mg/kg, i.p.) reduces plasma glucose and increases plasma GLP-1 in Streptozotocin (65 mg/kg, i.p.) induced type 1-like diabetic rats[2].
    Dipotassium glycyrrhizinate (50 mg/kg, i.p., once daily for 4 weeks) inhibits thyroiditis in the Iodine-induced murine model of autoimmune thyroiditis[3].
    Dipotassium glycyrrhizinate (50-200 mg/kg, i.p.,) inhibits Bleomycin (HY-108345)-induced pulmonary fibrosis IN rats[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Iodine-induced murine model of autoimmune thyroiditis[3]
    Dosage: 50 mg/kg
    Administration: i.p., once daily for 4 weeks
    Result: Reduced serum levels of TgAb, HMGB1, TNF-α, IL-6, IL-1β.
    Decreased The prevalence of thyroiditis and the infiltration of lymphocytes, and attenuated the severity of thyroiditis.
    Clinical Trial
    Molecular Weight

    899.11

    Formula

    C42H60K2O16
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    C[C@]12[C@@](C(C=C3[C@]2(CC[C@]4(C)[C@@]3([H])C[C@](C(O[K])=O)(C)CC4)C)=O)([H])[C@@]5([C@@](C(C)([C@@H](O[C@]6([H])[C@@H]([C@H]([C@H](O)[C@@H](C(O)=O)O6)O)O[C@]7([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]7O)C(O[K])=O)CC5)C)([H])CC1)C
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 50 mg/mL (55.61 mM; Need ultrasonic)

    DMSO : 20.83 mg/mL (23.17 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.1122 mL 5.5611 mL 11.1221 mL
    5 mM 0.2224 mL 1.1122 mL 2.2244 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (111.22 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

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    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.51%

    COA (256 KB) HNMR (331 KB) LCMS (86 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 1.1122 mL 5.5611 mL 11.1221 mL 27.8053 mL
    5 mM 0.2224 mL 1.1122 mL 2.2244 mL 5.5611 mL
    10 mM 0.1112 mL 0.5561 mL 1.1122 mL 2.7805 mL
    15 mM 0.0741 mL 0.3707 mL 0.7415 mL 1.8537 mL
    20 mM 0.0556 mL 0.2781 mL 0.5561 mL 1.3903 mL
    H2O 25 mM 0.0445 mL 0.2224 mL 0.4449 mL 1.1122 mL
    30 mM 0.0371 mL 0.1854 mL 0.3707 mL 0.9268 mL
    40 mM 0.0278 mL 0.1390 mL 0.2781 mL 0.6951 mL
    50 mM 0.0222 mL 0.1112 mL 0.2224 mL 0.5561 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Dipotassium glycyrrhizinate Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Dipotassium glycyrrhizinate68797-35-3Glycyrrhizic acid dipotassium Dipotassium glycyrrhizateVirus ProteaseInhibitorinhibitorinhibit

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