2. Metabolic Enzyme/Protease Autophagy
  3. Autophagy Phospholipase
  4. FIPI hydrochloride

FIPI hydrochloride  (Synonyms: 5-Fluoro-2-indolyl deschlorohalopemide hydrochloride)

Cat. No.: HY-12807A
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FIPI (5-Fluoro-2-indolyl des-chlorohalopemide) hydrochloride, a derivative of Halopemide (HY-119093), is a phospholipase D (PLD) inhibitor with IC50s of approximately 25 nM and 20 nM for PLD1 and PLD2, respectively. FIPI hydrochloride inhibits PLD regulation of F-actin cytoskeleton reorganization, cell spreading, and chemotaxis. FIPI hydrochloride has the potential for autoimmunity and cancer metastasis research.

For research use only. We do not sell to patients.

FIPI hydrochloride Chemical Structure

FIPI hydrochloride Chemical Structure

CAS No. : 1781834-93-2

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Top Publications Citing Use of Products

    FIPI hydrochloride purchased from MedChemExpress. Usage Cited in: Anal Chem. 2018 Jun 5;90(11):6742-6748.  [Abstract]

    Typical CSLM images of MDA-MB-231 cells incubated with 50 μg/mL RhB-PL-Ti3C2 for 4 h at 37°C in the absence (I) and presence of 1.0 mg/mL FIPI (II), and CSLM images of MCF-7 cells (III) incubated with 50 μg/mL RhB-PL-Ti3C2 for 4 h at 37°C.

    FIPI hydrochloride purchased from MedChemExpress. Usage Cited in: J Cell Sci. 2018 Mar 16;131(6). pii: jcs207217.  [Abstract]

    ER:Ras IMR90 cells are treated with solvent or FIPI (250 nM, 2h).Western blotting are performed.

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    Description

    FIPI (5-Fluoro-2-indolyl des-chlorohalopemide) hydrochloride, a derivative of Halopemide (HY-119093), is a phospholipase D (PLD) inhibitor with IC50s of approximately 25 nM and 20 nM for PLD1 and PLD2, respectively. FIPI hydrochloride inhibits PLD regulation of F-actin cytoskeleton reorganization, cell spreading, and chemotaxis. FIPI hydrochloride has the potential for autoimmunity and cancer metastasis research[1][2][3].

    IC50 & Target

    IC50: 25 nM (PLD1), 20 nM (PLD2)
    Molecular Weight

    457.93

    Formula

    C23H25ClFN5O2
    CAS No.
    SMILES

    O=C(NCCN1CCC(CC1)N2C3=CC=CC=C3NC2=O)C4=CC5=C(C=CC(F)=C5)N4.[H]Cl
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    FIPI hydrochloride Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    FIPI1781834-93-25-Fluoro-2-indolyl deschlorohalopemideAutophagyPhospholipasePLD1PLD2PLD regulationF-actin cytoskeleton reorganizationcell spreadingchemotaxisautoimmunityInhibitorinhibitorinhibit

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