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GDC-0941 dimethanesulfonate

HY-20180

(Pictilisib dimethanesulfonate; GDC-0941 (2 MeSO3H salt); GDC0941 dimethanesulfonate; GDC-0941; GDC0941; GDC 0941)

GDC-0941 dimethanesulfonate

GDC-0941 dimethanesulfonate Chemical Structure

GDC-0941 2 MeSO3H salt is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold).

Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO $110 In-stock
10 mg $100 In-stock
50 mg $240 In-stock
100 mg $440 In-stock
200 mg Get quote
500 mg Get quote
Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO €108 In-stock
10 mg €98 In-stock
50 mg €235 In-stock
100 mg €431 In-stock
200 mg Get quote
500 mg Get quote

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Product name: GDC-0941 dimethanesulfonate
Cat. No.: HY-20180

GDC-0941 dimethanesulfonate Data Sheet

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    Purity: 99.57%

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    DataSheet

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    COA

Related Compound Libraries

Biological Activity of GDC-0941 dimethanesulfonate

GDC-0941 2 MeSO3H salt is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold).
IC50 value: 3 nM
Target: PI3Kα/δ
GDC-0941 is a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer. GDC-0941 against p110a IC50=0.003μM,U87MG IC50=0.95μM, A2780 IC50=0.14 μM, and in vitro metabolic stability in mouse and human is 91.96%. The inhibitions of U87MG , PC3, MDA-MB-361 cancer cell proliferation are (IC50) 0.95, 0.28, 0.72 μM, respectively.

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 705.85 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C25H35N7O9S4
CAS No 957054-33-0
Solvent & Solubility

10 mM in DMSO

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 1.4167 mL 7.0837 mL 14.1673 mL
5 mM 0.2833 mL 1.4167 mL 2.8335 mL
10 mM 0.1417 mL 0.7084 mL 1.4167 mL

Clinical Information of GDC-0941 dimethanesulfonate

Product Name Sponsor Only Condition Start Date End Date Phase Last Change Date
GDC-0941 dimethanesulfonate Genentech Inc Metastatic non small cell lung cancer 31-JAN-12 31-MAR-16 Phase 2 14-NOV-13
Genentech Inc Metastatic breast cancer 31-OCT-11 30-SEP-15 Phase 2 14-NOV-13
Vanderbilt-Ingram Cancer Center Metastatic breast cancer 31-AUG-13 31-DEC-16 Phase 2 07-NOV-13
Genentech Inc Advanced solid tumor 30-NOV-09 31-MAR-14 Phase 1 07-NOV-13
Genentech Inc Metastatic breast cancer 28-FEB-13 31-AUG-16 Phase 2 14-NOV-13

References on GDC-0941 dimethanesulfonate

Other Forms

  • GDC-0941

    CAS No.: 957054-30-7 In-stock

Inhibitor Kit

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