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GDC-0941 dimethanesulfonate (Synonyms: Pictilisib dimethanesulfonate; GDC-0941 (2 MeSO3H salt); GDC0941 dimethanesulfonate; GDC-0941; GDC0941; GDC 0941)

Cat. No.: HY-20180 Purity: 99.57%
Handling Instructions

GDC-0941 2 MeSO3H salt is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold).

For research use only. We do not sell to patients.
GDC-0941 dimethanesulfonate Chemical Structure

GDC-0941 dimethanesulfonate Chemical Structure

CAS No. : 957054-33-0

Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO $99 In-stock
10 mg $90 In-stock
50 mg $220 In-stock
100 mg $350 In-stock
200 mg $600 In-stock
500 mg   Get quote  
1 g   Get quote  

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Other Forms of GDC-0941 dimethanesulfonate:

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Description

GDC-0941 2 MeSO3H salt is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold). IC50 value: 3 nM Target: PI3Kα/δ GDC-0941 is a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer. GDC-0941 against p110a IC50=0.003μM,U87MG IC50=0.95μM, A2780 IC50=0.14 μM, and in vitro metabolic stability in mouse and human is 91.96%. The inhibitions of U87MG , PC3, MDA-MB-361 cancer cell proliferation are (IC50) 0.95, 0.28, 0.72 μM, respectively.

Clinical Trial
Sponsor Condition Start Date Phase
Genentech Inc Metastatic breast cancer 2013-02-28 Phase 2
Genentech Inc Metastatic non small cell lung cancer 2012-01-31 Phase 2
Genentech Inc Metastatic breast cancer 2011-10-31 Phase 2
Vanderbilt-Ingram Cancer Center Metastatic breast cancer 2013-08-31 Phase 2
Genentech Inc Advanced solid tumor 2009-11-30 Phase 1
References
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 1.4167 mL 7.0837 mL 14.1673 mL
5 mM 0.2833 mL 1.4167 mL 2.8335 mL
10 mM 0.1417 mL 0.7084 mL 1.4167 mL
References
M.Wt

705.85

Formula

C₂₅H₃₅N₇O₉S₄

CAS No.

957054-33-0

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

Purity: 99.57%

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Product Name:
GDC-0941 dimethanesulfonate
Cat. No.:
HY-20180
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