Gefitinib impurity 1

Cat. No.: HY-131257 Purity: 99.59%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Gefitinib impurity 1 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC₅₀ of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC₅₀ of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity.

For research use only. We do not sell to patients.

Gefitinib impurity 1 Chemical Structure

CAS No. : 675126-26-8

Size	Price	Stock	Quantity
100 mg	USD 25	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Purity & Documentation
References
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Description

Molecular Weight

321.33

Formula

C₁₅H₁₉N₃O₅

CAS No.

675126-26-8

Appearance

Solid

Color

Light yellow to yellow

SMILES

N#CC1=CC(OCCCN2CCOCC2)=C(OC)C=C1[N+]([O-])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (155.60 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1121 mL	15.5603 mL	31.1207 mL
5 mM	0.6224 mL	3.1121 mL	6.2241 mL
10 mM	0.3112 mL	1.5560 mL	3.1121 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.59%

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Data Sheet (270 KB) SDS (393 KB)

COA (247 KB) HNMR (252 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Wakeling AE, et al. ZD1839: an orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy. Cancer Res. 2002 Oct 15;62(20):5749-54. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.1121 mL	15.5603 mL	31.1207 mL	77.8016 mL
	5 mM	0.6224 mL	3.1121 mL	6.2241 mL	15.5603 mL
	10 mM	0.3112 mL	1.5560 mL	3.1121 mL	7.7802 mL
	15 mM	0.2075 mL	1.0374 mL	2.0747 mL	5.1868 mL
	20 mM	0.1556 mL	0.7780 mL	1.5560 mL	3.8901 mL
	25 mM	0.1245 mL	0.6224 mL	1.2448 mL	3.1121 mL
	30 mM	0.1037 mL	0.5187 mL	1.0374 mL	2.5934 mL
	40 mM	0.0778 mL	0.3890 mL	0.7780 mL	1.9450 mL
	50 mM	0.0622 mL	0.3112 mL	0.6224 mL	1.5560 mL
	60 mM	0.0519 mL	0.2593 mL	0.5187 mL	1.2967 mL
	80 mM	0.0389 mL	0.1945 mL	0.3890 mL	0.9725 mL
	100 mM	0.0311 mL	0.1556 mL	0.3112 mL	0.7780 mL