2. Gene
  3. Pdia3 - protein disulfide isomerase family A, member 3 Gene

Pdia3 - protein disulfide isomerase family A, member 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as ER60; ERp57; Grp58

Gene ID: 29468 | Gene type: protein coding

About Pdia3

Primary_assembly 3: 108,388,245-108,413,236 forward strand.mRatBN7.2:CM026976.1

This gene has 2 transcripts (splice variants), 225 orthologues, 14 paralogues and is associated with 19 phenotypes. Biased expression in Liver (RPKM 638.3), Spleen (RPKM 616.4) and 9 other tissues.

Summary

Enables MHC class I protein binding activity; peptidase activity; and protein-disulfide reductase (glutathione) activity. Involved in several processes, including cellular response to nonylphenol; response to benzene; and response to ischemia. Located in several cellular components, including acrosomal vesicle; mitochondrial intermembrane space; and smooth endoplasmic reticulum. Part of TAP complex. Used to study autoimmune hepatitis and irritable bowel syndrome. Biomarker of asphyxia neonatorum; irritable bowel syndrome; liver cirrhosis; post-traumatic stress disorder; and pulmonary hypertension. Human ortholog(s) of this gene implicated in autoimmune hepatitis. Orthologous to human PDIA3 (protein disulfide isomerase family A member 3). [provided by Alliance of Genome Resources, Apr 2022]

Pdia3 Products(1)

mRNA Protein Name
NM_017319.2 NP_059015.2 protein disulfide-isomerase A3 precursor

Pdia3 Protein Structure

ER_PDI_fam

ER_PDI_fam: cl36828 (30 - 491)

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  • 510 a.a.
Protein Preferred Names Protein Names

protein disulfide-isomerase A3

58 kDa glucose-regulated protein

58 kDa microsomal protein

ER protein 57

ER protein 60

ER-60 protease

ERp60

HIP-70

Q-2

disulfide isomerase ER-60

endoplasmic reticulum resident protein 57

endoplasmic reticulum resident protein 60

glucose regulated protein, 58 kDa

oxidoreductase ERp57

p58

protein disulfide isomerase associated 3

Related Agents

Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N0177 Diosgenin Inhibitor 99.20% Unkown
HY-100432 LOC14 ≥98.0% Unkown
HY-122895 E64FC26 98.10% Unkown
HY-122895A (E/Z)-E64FC26 98.09% Unkown
HY-151286 Antitumor agent-73 Inhibitor / Unkown
HY-RS10266 PDIA3 Human Pre-designed siRNA Set A / Unkown
HY-RS10267 Pdia3 Mouse Pre-designed siRNA Set A / Unkown
HY-RS10268 Pdia3 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pdia3 NCBI NCBI:2923