1. Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
  2. JAK
    STAT

Diosgenin 

Cat. No.: HY-N0177
Handling Instructions

Diosgenin, an important natural source of steroidal hormones, has favorable effects in the improvement of diabetes and regulation of lipid metabolism.

For research use only. We do not sell to patients.
Diosgenin Chemical Structure

Diosgenin Chemical Structure

CAS No. : 512-04-9

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Customer Review

    Diosgenin purchased from MCE. Usage Cited in: Cell Physiol Biochem. 2016;39(4):1626-37.

    Arithmetic means ± SEM (n = 10) of erythrocyte annexin-V-binding following incubation for 48 hours to Ringer solution without (white bar) or with (black bars) Diosgenin (5-15 µM).
    • Biological Activity

    • Protocol

    • Technical Information

    • References

    Description

    Diosgenin, an important natural source of steroidal hormones, has favorable effects in the improvement of diabetes and regulation of lipid metabolism. IC50 value: Target: In vitro: In MC65 cells, a cellular AD model, diosgenin exhibited weak protective abilities at 1 μM, may represent a good candidate as a steroidal moiety in our bivalent compounds against AD pathology [1]. In vivo: Diosgenin treatment significantly reduced fasted and refed blood glucose level in HF dietfed mice. Diosgenin treatment significantly reduced blood glucose level in IPGTT test, compared with that of HF diet-fed mice [2].

    References
    Preparing Stock Solutions
    Concentration Volume Mass 1 mg 5 mg 10 mg
    1 mM 2.4118 mL 12.0592 mL 24.1185 mL
    5 mM 0.4824 mL 2.4118 mL 4.8237 mL
    10 mM 0.2412 mL 1.2059 mL 2.4118 mL
    Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    414.62

    Formula

    C₂₇H₄₂O₃

    CAS No.

    512-04-9

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    Shipping

    Room temperature in continental US; may vary elsewhere

    Solvent & Solubility

    10 mM in DMSO

    * "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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    Product Name:
    Diosgenin
    Cat. No.:
    HY-N0177
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