2. Gene
  3. Tbk1 - TANK-binding kinase 1 Gene

Tbk1 - TANK-binding kinase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as 1200008B05Rik

Gene ID: 56480 | Gene type: protein coding

About Tbk1

Chromosome 10: 121,382,360-121,422,692 reverse strand.GRCm39:CM001003.3

This gene has 7 transcripts (splice variants), 201 orthologues, 3 paralogues and is associated with 38 phenotypes. Ubiquitous expression in bladder adult (RPKM 7.5), CNS E11.5 (RPKM 7.4) and 28 other tissues.

Summary

Enables several functions, including identical protein binding activity; protein Phosphatase binding activity; and protein serine/threonine kinase activity. Involved in negative regulation of gene expression; peptidyl-serine phosphorylation; and positive regulation of defense response. Acts upstream of or within several processes, including defense response to Gram-positive bacterium; dendritic cell proliferation; and positive regulation of interferon-beta production. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in brain disease and frontotemporal dementia and/or amyotrophic lateral sclerosis-4. Orthologous to human TBK1 (TANK binding kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Tbk1 Products(1)

mRNA Protein Name
NM_019786.4 NP_062760.3 serine/threonine-protein kinase TBK1

Tbk1 Protein Structure

STKc_TBK1

STKc_TBK1: cd13988 (14 - 329)

Ubl_TBK1

Ubl_TBK1: cd17127 (307 - 384)

TBK1_CCD1

TBK1_CCD1: pfam18394 (399 - 654)

TBK1_C

TBK1_C: cd21954 (677 - 723)

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  • 729 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase TBK1

T2K

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0713 Amlexanox Inhibitor 99.88% Unkown
Pre-clinical Phase
Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10514 BX795 Inhibitor 99.17% Unkown
HY-111941 GSK8612 Inhibitor 99.33% Unkown
HY-13018 MRT67307 Inhibitor 99.34% Unkown
HY-133117 BAY-985 Inhibitor 99.88% Unkown
HY-152237 TBK1-IN-1 Inhibitor 99.91% Unkown
HY-124652 TBK1/IKKε-IN-4 Inhibitor 99.83% Unkown
HY-12453 TBK1/IKKε-IN-2 Inhibitor 98.09% Unkown
HY-14682 GSK319347A Inhibitor 99.40% Unkown
HY-13018A MRT67307 hydrochloride Inhibitor / Unkown
HY-133117A (Rac)-BAY-985 Inhibitor / Unkown
HY-U00457 TBK1/IKKε-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tbk1 NCBI NCBI:29110