2. Gene
  3. KEAP1 - kelch like ECH associated protein 1 Gene

KEAP1 - kelch like ECH associated protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as INrf2; KLHL19

Gene ID: 9817 | Gene type: protein coding

About KEAP1

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,486,125-10,503,356 (from NCBI)

This gene has 10 transcripts (splice variants), 189 orthologues, 54 paralogues and is associated with 94 phenotypes. Ubiquitous expression in kidney (RPKM 10.4), prostate (RPKM 9.9) and 25 other tissues.

Summary

This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]

KEAP1 Products(6)

mRNA Protein Name
XM_011528452.2 XP_011526754.1 kelch-like ECH-associated protein 1 isoform X1
NM_203500.2 NP_987096.1 kelch-like ECH-associated protein 1
XM_005260174.2 XP_005260231.1 kelch-like ECH-associated protein 1 isoform X1
XM_005260173.2 XP_005260230.1 kelch-like ECH-associated protein 1 isoform X1
NM_012289.4 NP_036421.2 kelch-like ECH-associated protein 1
XM_047439788.1 XP_047295744.1 kelch-like ECH-associated protein 1 isoform X2

KEAP1 Protein Structure

BTB

BTB: BTB/POZ domain (67 - 178)

BACK

BACK: BTB And C-terminal Kelch (185 - 285)

Kelch_1

Kelch_1: Kelch motif (324 - 358)

Kelch_1

Kelch_1: Kelch motif (361 - 410)

Kelch_1

Kelch_1: Kelch motif (412 - 456)

Kelch_1

Kelch_1: Kelch motif (459 - 503)

Kelch_1

Kelch_1: Kelch motif (507 - 550)

Kelch_1

Kelch_1: Kelch motif (553 - 597)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 624 a.a.
Protein Preferred Names Protein Names

kelch-like ECH-associated protein 1

KEAP1 delta C

cytosolic inhibitor of Nrf2

kelch-like family member 19

kelch-like protein 19

Recombinant KEAP1 Proteins

Cat. No. Product Name Accession Purity
HY-P75897 KEAP1 Protein, Human (sf9) Q14145 (Q2-C624) ≥95%
HY-P75898 KEAP1 Protein, Human (sf9, His-GST-Avi) Q14145 (Q2-C624) ≥95%
HY-P75899 KEAP1 Protein, Human (sf9, His-GST) Q14145 (Q2-C624) ≥95%

Related Diseases

Diseases Alias
Fumarase Deficiency

Fumaric Aciduria

FMRD

Fumarate Hydratase Deficiency

Deficiency, Fumarase
Parkinson Disease 17

PARK17

Parkinson'S Disease 17

Autosomal Dominant Parkinson Disease 17

Parkinson Disease, Type 17
Penis Carcinoma In Situ

Carcinoma In Situ Of Penis

Bowen'S Disease Of Penis

Grade Iii Squamous Intraepithelial Lesion Of Penis

Penile Intraepithelial Neoplasia Grade Iii

Queyrat'S Erythroplasia

Erythroplasia Of Queyrat

Pin - [Penile Intraepithelial Neoplasia]
Diabetes Mellitus

Diabetes
Microphthalmia, Isolated 1

Isolated Microphthalmia 1

MCOP1

Mcop

Anophthalmia, Clinical, Isolated

Microphthalmos, Autosomal Recessive
Goiter, Multinodular 1, With Or Without Sertoli-Leydig Cell Tumors

Euthyroid Goiter

MNG1

Simple Goiter

Goiter Euthyroid

Goiter, Nontoxic, With Intrathyroidal Calcification

Multinodular Goiter, Adolescent

Familial Multinodular Goiter

Fmng

Familial Mng

Familial Multinodular Goiter Syndrome

Goiter Multinodular 1, With Or Without Sertoli-Leydig Cell Tumors

Goiter Nontoxic With Intrathyroidal Calcification

Goiter Non-Toxic With Intrathyroidal Calcification

Multinodular Goiter Adolescent

Goiter, Multinodular, Type 1, With/Without Sertoli-Leydig Cell Tumors

Endemic Goiter
Trichothiodystrophy 4, Nonphotosensitive

Amish Brittle Hair Brain Syndrome

TTD4

Trichothiodystrophy, Nonphotosensitive 1

Hair-Brain Syndrome

Bids Syndrome

Ttdn1

Abhs

Pollitt Syndrome

Trichothiodystrophy-Neurocutaneous Syndrome

Nonphotosensitive Trichothiodystrophy 4

Trichorrhexis Nodosa Syndrome

Trichothiodystrophy 4, Non-Photosensitive

Trichothiodystrophy Non-Photosensitive 1
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Protection Against

Lung Cancer, Susceptibility To

Adenocarcinoma Of Lung, Somatic

Nonsmall Cell Lung Cancer

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
Renal Cell Carcinoma, Papillary, 1

Papillary Renal Cell Carcinoma

Hereditary Papillary Renal Cell Carcinoma

Papillary Renal Cell Carcinoma, Sporadic

Papillary Renal Cell Adenocarcinoma

RCCP

RCCP1

Renal Cell Carcinoma, Papillary

Renal Cell Carcinoma, Papillary, 1, Familial And Somatic

Chromophil Carcinoma Of Kidney

Papillary Kidney Carcinoma

Sporadic Papillary Renal Cell Carcinoma

Chromophil Renal Cell Carcinoma

Papillary Renal Carcinoma, Malignant -

Papillary Renal Cell Carcinoma, Bilateral -

Papillary Renal Cell Carcinoma, Familial -

Papillary Renal Cell Carcinoma, Multiple -

Papillary Renal Cell Carcinoma, Sporadic -

Renal Adenocarcinoma

Chromophil Rcc

Hprcc

Renal Cell Carcinoma Papillary

Chromophilic Renal Cell Carcinoma

Prcc

Carcinoma, Renal Cell, Papillary, Type 1

Type 1 Papillary Renal Cell Carcinoma

Renal Cell Carcinoma

Hereditary Papillary Renal Carcinoma
Pulmonary Large Cell Neuroendocrine Carcinoma

Large Cell Lung Neuroendocrine Carcinoma
Squamous Cell Carcinoma

Epidermoid Carcinoma

Squamous Cell Cancer

Carcinoma, Squamous Cell

Malignant Squamous Cell Tumor

Squamous Carcinoma

Squamous Cell Epithelioma

Squamous Cell Skin Cancer

Carcinoma Squamous Cell

Neoplasms, Squamous Cell

Squamous Cell Carcinoma - Category

Malignant Squamous Cell Neoplasm

Squamous Cell Carcinoma Of Skin
Lung Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Lung

Squamous Cell Lung Carcinoma

Epidermoid Cell Carcinoma Of The Lung

Squamous Cell Lung Cancer
Cataract

Cataracts

Cat - [Cataract]

Cataract Form

Lens Opacity

Lens Opacities
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Large Cell Carcinoma With Rhabdoid Phenotype

Large Cell Lung Carcinoma With Rhabdoid Phenotype
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-N0005 Curcumin 98.84% Phase 4
HY-13755 Sulforaphane 99.75% Phase 4
Pre-clinical Phase
Bioactive Molecules (56)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100218A RSL3 99.90% Unkown
HY-112675 4-Octyl itaconate Activator 99.98% Unkown
HY-101140 KI696 Inhibitor 99.26% Unkown
HY-110258 ML334 Activator 99.76% Unkown
HY-134205A CBR-470-1 Activator 98.03% Unkown
HY-111126 K67 Activator 98.43% Unkown
HY-13755A (R)-Sulforaphane 99.37% Unkown
HY-110275 RA839 98.90% Unkown
HY-120371 CPUY192018 Inhibitor 98.99% Unkown
HY-145879 Nrf2 activator-2 Activator 98.92% Unkown
HY-W009731 Dibenzoylmethane Activator ≥98.0% Unkown
HY-139047 SW157765 Inhibitor 98.67% Unkown
HY-131592 Tricetin 99.19% Unkown
HY-101140A KI696 isomer Inhibitor 99.32% Unkown
HY-P1328 TAT-14 Activator 99.66% Unkown
HY-122054A BPK-29 hydrochloride Inhibitor 98.28% Unkown
HY-139620A MS83 epimer 1 / Unkown
HY-149010 NXPZ-2 Inhibitor / Unkown
HY-122054 BPK-29 Inhibitor ≥99.0% Unkown
HY-110258B (R,S,R)-ML334 98.57% Unkown
HY-121523 MIND4-17 Activator 99.93% Unkown
HY-139620 MS83 Chemical / Unkown
HY-100218C (1R,3R)-RSL3 / Unkown
HY-124941 7-Deacetylgedunin Activator / Unkown
HY-139862 Keap1-Nrf2-IN-3 Inhibitor / Unkown
HY-143892 Keap1-Nrf2-IN-5 Inhibitor / Unkown
HY-143893 Keap1-Nrf2-IN-6 Inhibitor / Unkown
HY-144099 Keap1-Nrf2-IN-4 / Unkown
HY-146577 Keap1-Nrf2-IN-7 Inhibitor / Unkown
HY-146578 Keap1-Nrf2-IN-8 Inhibitor / Unkown
HY-147517 Keap1-Nrf2-IN-9 Inhibitor / Unkown
HY-147548 Keap1-Nrf2-IN-10 Inducer / Unkown
HY-147924 Keap1-Nrf2-IN-11 Inhibitor / Unkown
HY-149245 Keap1-Nrf2-IN-15 Inhibitor / Unkown
HY-149508 Nrf2-IN-3 Inhibitor / Unkown
HY-150578 Keap1-Nrf2-IN-12 Inhibitor / Unkown
HY-150579 Keap1-Nrf2-IN-13 Inhibitor / Unkown
HY-151362 Keap1-Nrf2-IN-14 Inhibitor / Unkown
HY-155997 Anti-inflammatory agent 56 Inhibitor / Unkown
HY-156065 S217879 Activator / Unkown
HY-157928 Keap1-Nrf2-IN-18 Inhibitor / Unkown
HY-157929 Keap1-Nrf2-IN-19 Inhibitor / Unkown
HY-158055 Keap1-Nrf2-IN-20 Inhibitor / Unkown
HY-162152 biKEAP1 Inhibitor / Unkown
HY-N10313 Dehydrobruceine B / Unkown
HY-N8160 Dehydrocurdione / Unkown
HY-P1328A TAT-14 TFA Activator / Unkown
HY-P5480 Keap1-Nrf2-IN-16 / Unkown
HY-P5909 Keap1-Nrf2 probe / Unkown
HY-P5909F FITC-labelled Keap1-Nrf2 probe / Unkown
HY-RS07230 KEAP1 Human Pre-designed siRNA Set A / Unkown
HY-RS07231 Keap1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS07232 Keap1 Rat Pre-designed siRNA Set A / Unkown
HY-112675S 4-Octyl itaconate-13C5-1 / Unkown
HY-162096 Keap1-Nrf2-IN-17 Inhibitor / Unkown
HY-W505984 TPNA10168 Activator / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus KEAP1 MGD MGI:1858732
Felis catus KEAP1 VGNC VGNC:63076
Macaca mulatta KEAP1 VGNC VGNC:73891
Canis familiaris KEAP1 VGNC VGNC:42332
Rattus norvegicus KEAP1 RGD RGD:621619
Bos taurus KEAP1 VGNC VGNC:30537
Others KEAP1 NCBI