2. ICI-204448

ICI-204448 is a κ-opioid agonist with limited access to the CNS, ICI-204448 can displace the binding of the kappa-opioid ligand 3H-bremazocine from guinea pig cerebellum membranes.

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ICI-204448 Chemical Structure

ICI-204448 Chemical Structure

CAS No. : 121264-04-8

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5 mg USD 312 In-stock
10 mg USD 499 In-stock
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Description

ICI-204448 is a κ-opioid agonist with limited access to the CNS, ICI-204448 can displace the binding of the kappa-opioid ligand 3H-bremazocine from guinea pig cerebellum membranes[1].

Molecular Weight

501.83

Formula

C23H27Cl3N2O4
CAS No.
Appearance

Solid

Color

Off-white to yellow

SMILES

O=C(O)COC1=CC=CC(C(N(C(CC2=CC=C(Cl)C(Cl)=C2)=O)C)CN3CCCC3)=C1.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (249.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9927 mL 9.9635 mL 19.9271 mL
5 mM 0.3985 mL 1.9927 mL 3.9854 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9927 mL 9.9635 mL 19.9271 mL 49.8177 mL
5 mM 0.3985 mL 1.9927 mL 3.9854 mL 9.9635 mL
10 mM 0.1993 mL 0.9964 mL 1.9927 mL 4.9818 mL
15 mM 0.1328 mL 0.6642 mL 1.3285 mL 3.3212 mL
20 mM 0.0996 mL 0.4982 mL 0.9964 mL 2.4909 mL
25 mM 0.0797 mL 0.3985 mL 0.7971 mL 1.9927 mL
30 mM 0.0664 mL 0.3321 mL 0.6642 mL 1.6606 mL
40 mM 0.0498 mL 0.2491 mL 0.4982 mL 1.2454 mL
50 mM 0.0399 mL 0.1993 mL 0.3985 mL 0.9964 mL
60 mM 0.0332 mL 0.1661 mL 0.3321 mL 0.8303 mL
80 mM 0.0249 mL 0.1245 mL 0.2491 mL 0.6227 mL
100 mM 0.0199 mL 0.0996 mL 0.1993 mL 0.4982 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ICI-204448121264-04-8ICI204448ICI 204448Inhibitorinhibitorinhibit

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