item/HY-10182

By Targets:	Antibiotic (1) Apoptosis (1) Autophagy (4) Cannabinoid Receptor (1) Endogenous Metabolite (1) GSK-3 (5) Histamine Receptor (1) Organoid (3) Parasite (1) Prostaglandin Receptor (1) Small Interfering RNA (siRNA) (1) TGF-beta/Smad (1) Wnt (5) β-catenin (5)
By Research Areas:	Cancer (6) Endocrinology (1) Infection (3) Inflammation/Immunology (1) Metabolic Disease (7)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10182G

Laduviglusib CHIR-99021; CT99021	GSK-3 Wnt β-catenin Autophagy	Metabolic Disease Cancer
Laduviglusib (CHIR-99021) (GMP) is Laduviglusib (HY-10182) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Laduviglusib is a potent, orally active and selective GSK-3α/β inhibitor.

HY-10182

Laduviglusib Maximum Cited Publications 147 Publications Verification CHIR-99021; CT99021	Organoid GSK-3 Wnt β-catenin Autophagy	Metabolic Disease Cancer
Laduviglusib (CHIR-99021) is a potent, selective and orally active GSK-3α/β inhibitor with IC₅₀s of 10 nM and 6.7 nM. Laduviglusib shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib enhances mouse and human embryonic stem cells self-renewal. Laduviglusib induces autophagy .

HY-10182A

Laduviglusib monohydrochloride Maximum Cited Publications 147 Publications Verification CHIR-99021 monoHYdrochloride; CT99021 monoHYdrochloride	Organoid GSK-3 Wnt β-catenin Autophagy	Cancer
Laduviglusib (CHIR-99021) monohydrochloride is a potent and selective GSK-3α/β inhibitor with IC₅₀s of 10 nM and 6.7 nM. Laduviglusib monohydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib monohydrochloride is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib monohydrochloride enhances mouse and human embryonic stem cells self-renewal. Laduviglusib monohydrochloride induces autophagy .

HY-10182B

Laduviglusib trihydrochloride Maximum Cited Publications 147 Publications Verification CHIR-99021 triHYdrochloride; CT99021 triHYdrochloride	Organoid GSK-3 Wnt β-catenin Autophagy	Cancer
Laduviglusib (CHIR-99021) trihydrochloride is a potent and selective GSK-3α/β inhibitor with IC₅₀s of 10 nM and 6.7 nM. Laduviglusib trihydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib trihydrochloride is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib trihydrochloride enhances mouse and human embryonic stem cells self-renewal. Laduviglusib trihydrochloride induces autophagy .

HY-10182C

Laduviglusib dihydrochloride CHIR-99021 diHYdrochloride; CT99021 diHYdrochloride	GSK-3 β-catenin Wnt	Metabolic Disease Cancer
Laduviglusib;CHIR 99021;CHIR99021;CHIR-99021;CT99021;CT 99021;CT-99021

HY-W013579

(S)-(+)-Carvone

D-Carvone
Others Others

(S)-(+)-Carvone (D Carvone) is a naturally occuring conmpound found in several food items and can be used in flavouring foods .

(S)-(+)-Carvone D-Carvone	Others	Others
(S)-(+)-Carvone (D Carvone) is a naturally occuring conmpound found in several food items and can be used in flavouring foods .

HY-116661

Cannabigerovarin CBGV	Cannabinoid Receptor	Metabolic Disease
Cannabigerovarin (CRM) (Item No. 29117) is a certified reference material categorized as a phytocannabinoid.1 This product is intended for research and forensic applications.

HY-145525

Linoleoyl-L-carnitine chloride CAR 18:2; C18:2 Carnitine; L-Carnitine linoleoyl ester	Others	Others
Linoleoyl-L-carnitine is a naturally occurring long-chain acylcarnitine. Hepatic levels of linoleoyl-L-carnitine are increased following high-dose (200 mg/kg) administration of Isoniazid (Item No. 20378) in mice.

HY-130340

Teicoplanin A3-1 Teichomycin A3 factor 1; Antibiotic L 17054	Others	Infection
Teicoplanin A3-1 is a degradation product of teicoplanins A2-1 to 5 (Item Nos. 20187, 20188, 20189, 20192). Teicoplanins are glycopeptide antibiotics produced by A. teichomyceticus that are broadly effective against Gram-positive bacteria in vitro.

HY-P10182

Angiotensin III antipeptide

Antibiotic Infection

Angiotensin III antipeptide is a peptide antibiotic .

Angiotensin III antipeptide	Antibiotic	Infection
Angiotensin III antipeptide is a peptide antibiotic .

HY-N10182

Spinacetin	Histamine Receptor	Inflammation/Immunology
Spinacetin is a natural product that can be isolated from Inula japonica. Spinacetin inhibits the release of histamine. Spinacetin has anti-inflammatory activity .

HY-RS10182

PCYT2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PCYT2 Human Pre-designed siRNA Set A contains three designed siRNAs for PCYT2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PCYT2 Human Pre-designed siRNA Set A PCYT2 Human Pre-designed siRNA Set A

HY-124200

AL 8810 isopropyl ester	Prostaglandin Receptor	Endocrinology
AL 8810 (Item No. 16735) is an 11β-fluoro analog of prostaglandin F2α which acts as a potent and selective antagonist at the FP receptor. AL 8810 isopropyl ester is a lipid soluble, esterified prodrug form of AL 8810 analogous to the commonly used therapeutic intraocular prostaglandin compounds such as Latanoprost (HY-B0577) and Travoprost (HY-B0584).

HY-129303

AP219	Endogenous Metabolite	Metabolic Disease
AP39 (Item No. 17100) is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria. It consists of a mitochondria-targeting motif (triphenylphosphonium) coupled to an H2S-donating moiety (dithiolethione) by an aliphatic linker. AP219 is a control compound for AP39, containing the triphenylphosphonium scaffold but lacking the H2S-releasing portion.

HY-W105318

Pentabromophenol PBP	TGF-beta/Smad Apoptosis	Cancer
Pentabromophenol (PBP) is a brominated flame retardant (BFR) widely used in various consumer products to reduce the flammability of materials used in different utility items. Pentabromophenol can accelerate the degradation of transforming growth factor-β (TGF-β) receptors by promoting clathrin-mediated endocytosis, thereby inhibiting the TGF-β signaling pathway. Additionally, Pentabromophenol can also induce apoptosis in peripheral blood mononuclear cells (PBMCs) .

HY-134123

Lipoxin B4 methyl ester LXB4 metHYl ester	Others	Metabolic Disease
Lipoxin B4 (LXB4) methyl ester is a lipid soluble prodrug form of the transcellular metabolite LXB4. LXB4 is a positional isomer of LXA4 produced by the metabolism of 15-HETE or 15-HpETE by human leukocytes. At a concentration of 100 nM, LXB4 inhibits polymorphonuclear leukocyte (PMN) migration stimulated by leukotriene B4 (LTB4; Item No. 20110) and inhibits LTB4-induced adhesion of PMNs with an IC₅₀ value of 0.3 nM.

HY-137555

11-dehydro-2,3-dinor Thromboxane B2 11-deHYdro-2,3-dinor TXB2	Others	Metabolic Disease
11-dehydro-2,3-dinor Thromboxane B2 (11-dehydro-2,3-dinor TXB2) is a metabolite of the TXA2 inactive metabolite TXB2 (Item No. 19030). It is formed from TXB2 by cytosolic aldehyde dehydrogenase (ALDH) and β-oxidation. Levels of 11-dehydro-2,3-dinor TXB2 are increased 5.2-fold in a surgery-induced rat model of tendon overuse.

HY-138074

Milbemycin A4 oxime 5-Ketomilbemycin A4 oxime; 5-Oxomilbemycin A4 5-oxime	Parasite	Infection
Milbemycin A4 oxime is a derivative of milbemycin A4 (Item No. 17155) and a component of Milbemycin Oxime (HY-B0778), compounds that both have insecticidal and nematocidal activity. Milbemycin A4 oxime (0.05 mg/kg) reduces the number of microfilariae of the heartworm D. immitis in naturally infested dogs. It inhibits the growth of clinical isolates of C. glabrata with MIC80 values ranging from 16 to greater than 32 μg/mL.1 Milbemycin A4 oxime (2.5 μg/mL) blocks efflux of Fluconazole (HY-B0101) from a clinical isolate of C. glabrata, but not from a strain lacking the efflux pumps CgCDR1 and PDH1, and reduces the MICs of fluconazole and 4-nitroquinoline 1-oxide in wild-type C. glabrata. It enhances adriamycin-induced inhibition of cell growth, as well as increases the intracellular accumulation of adriamycin and the P-glycoprotein substrate Rhodamine 123 (HY-D0816), in adriamycin-resistant, but not -sensitive, MCF-7 breast cancer cells in a concentration-dependent manner.

Cat. No.	Product Name

HY-L0096V

Vitas-M Screening Compounds Library	1,400,000 compounds
Vitas-M Screening Compounds Library (stock) contains about 1,400,000 chemical substances. They are synthetic small molecule organic compounds for biological screening and lead optimization. Select any number of items as a "cherry pick".

HY-L055

Medicine Food Homology Compound Library	1,725 compounds
Medicine Food Homology (MFH) means that some food themselves are medicines and there is no absolute boundary between them. MFH theory combines the function of food and medicine together scientifically and MFH materials can be used both for food and medicine. Besides nutritional value, MFH materials also have the functions in the prevention and treatment of disease and many other healthcare effects. Food as medicines has many benefits because of their safety while taking drugs will bring inevitable side effect to people. In order to ensure the safe use of functional food, National Health Commission of People's Republic of China made specific provisions on MFH items. More than 100 kinds of widely used MFH materials have been released. Based on MFH items released by National Health Commission, PRC, MCE carefully designs a unique collection of 1,725 Medicine Food Homology Compounds with high safety that can be used for high throughput and high content screening for drug discovery.

Medicine Food Homology Compound Library

1,725 compounds

Medicine Food Homology (MFH) means that some food themselves are medicines and there is no absolute boundary between them. MFH theory combines the function of food and medicine together scientifically and MFH materials can be used both for food and medicine. Besides nutritional value, MFH materials also have the functions in the prevention and treatment of disease and many other healthcare effects. Food as medicines has many benefits because of their safety while taking drugs will bring inevitable side effect to people. In order to ensure the safe use of functional food, National Health Commission of People's Republic of China made specific provisions on MFH items. More than 100 kinds of widely used MFH materials have been released.

Based on MFH items released by National Health Commission, PRC, MCE carefully designs a unique collection of 1,725 Medicine Food Homology Compounds with high safety that can be used for high throughput and high content screening for drug discovery.

HY-L0088V

Life Chemicals 50K Diversity Library	50,240 compounds
Life Chemicals presents a number of exclusive Pre-Plated Diversity Sets composed of 50,240 novel compounds with optimal physicochemical properties selected from Life Chemicals collection of newly synthesized items by dissimilarity search with an average Tanimoto threshold of 82%. These Diverse Screening Sets are ideal starting points for customers looking for a wide range of dissimilarity to screen against a number of targets from different classes or where little information is available on targeted protein structure.

Life Chemicals 50K Diversity Library

50,240 compounds

Life Chemicals presents a number of exclusive Pre-Plated Diversity Sets composed of 50,240 novel compounds with optimal physicochemical properties selected from Life Chemicals collection of newly synthesized items by dissimilarity search with an average Tanimoto threshold of 82%. These Diverse Screening Sets are ideal starting points for customers looking for a wide range of dissimilarity to screen against a number of targets from different classes or where little information is available on targeted protein structure.

Cat. No.	Product Name	Type

HY-10182G

Laduviglusib (GMP) CHIR-99021 (GMP); CT99021 (GMP)	Fluorescent Dye
Laduviglusib (CHIR-99021) (GMP) is Laduviglusib (HY-10182) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Laduviglusib is a potent, orally active and selective GSK-3α/β inhibitor.

Cat. No.	Product Name	Type

HY-10182G

Laduviglusib (GMP) CHIR-99021 (GMP); CT99021 (GMP)	Biochemical Assay Reagents
Laduviglusib (CHIR-99021) (GMP) is Laduviglusib (HY-10182) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Laduviglusib is a potent, orally active and selective GSK-3α/β inhibitor.

Cat. No.	Product Name	Target	Research Area

HY-P10182

Angiotensin III antipeptide

Antibiotic Infection

Angiotensin III antipeptide is a peptide antibiotic .

Angiotensin III antipeptide	Antibiotic	Infection
Angiotensin III antipeptide is a peptide antibiotic .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W013579

(S)-(+)-Carvone D-Carvone	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Gymnaster koraiensis Other Diseases Plants Umbelliferae Disease Research Fields	Others
(S)-(+)-Carvone (D Carvone) is a naturally occuring conmpound found in several food items and can be used in flavouring foods .

HY-N10182

Spinacetin	Phyllodium pulchellum (L.) Desv. Structural Classification Flavonols Flavonoids Source classification Plants Compositae	Histamine Receptor
Spinacetin is a natural product that can be isolated from Inula japonica. Spinacetin inhibits the release of histamine. Spinacetin has anti-inflammatory activity .

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
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item/HY-10182

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Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

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