2. Academic Validation
  3. Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design

Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design

  • J Med Chem. 2005 Jun 30;48(13):4212-5. doi: 10.1021/jm050355z.
Brian W Dymock 1,  Xavier Barril,  Paul A Brough,  Julie E Cansfield,  Andrew Massey,  Edward McDonald,  Roderick E Hubbard,  Allan Surgenor,  Stephen D Roughley,  Paul Webb,  Paul Workman,  Lisa Wright,  Martin J Drysdale
Affiliations

Affiliation

  • 1 Vernalis Ltd., Granta Park, Great Abington, Cambridge, UK.
PMID: 15974572 DOI: 10.1021/jm050355z
Abstract

The crystal structure of a previously reported screening hit 1 (CCT018159) bound to the N terminal domain of molecular chaperone HSP90 has been used to design 5-amide analogues. These exhibit enhanced potency against the target in binding and functional assays with accompanying appropriate cellular pharmacodynamic changes. Compound 11 (VER-49009) compares favorably with the clinically evaluated 17-AAG.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-15986
    99.39%, HSP Inhibitor
    HSP