2. Academic Validation
  3. Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpurines

Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpurines

  • Bioorg Med Chem Lett. 2008 May 1;18(9):2924-9. doi: 10.1016/j.bmcl.2008.03.072.
Roger J Gillespie 1,  Ian A Cliffe,  Claire E Dawson,  Colin T Dourish,  Suneel Gaur,  Allan M Jordan,  Antony R Knight,  Joanne Lerpiniere,  Anil Misra,  Robert M Pratt,  Jonathan Roffey,  Gemma C Stratton,  Rebecca Upton,  Scott M Weiss,  Douglas S Williamson
Affiliations

Affiliation

  • 1 Vernalis (R&D) Ltd, 613 Reading Road, Winnersh RG41 5UA, UK.
PMID: 18411049 DOI: 10.1016/j.bmcl.2008.03.072
Abstract

A series of pyrazolo[3,4-d]pyrimidine, pyrrolo[2,3-d]pyrimidine and 6-arylpurine adenosine A(2A) antagonists is described. Many examples were highly selective against the human A(1) receptor sub-type and were active in an in vivo model of Parkinson's disease.

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