1. GPCR/G Protein
  2. Adenosine Receptor

Adenosine Receptor

Adenosine receptors (ARs) comprise a group of G protein-coupled receptors (GPCR) which mediate the physiological actions of adenosine. To date, four AR subtypes have been cloned and identified in different tissues. These receptors have distinct localization, signal transduction pathways and different means of regulation upon exposure to agonists. A key property of some of Adenosine receptors is their ability to serve as sensors of cellular oxidative stress, which is transmitted by transcription factors, such as NF-κB, to regulate the expression of ARs. The importance of Adenosine receptors in the regulation of normal and pathological processes such as sleep, the development of cancers and in protection against hearing loss will be examined.

Adenosine Receptor Related Products (25):

Cat. No. Product Name Effect Purity
  • HY-10889
    Preladenant Antagonist 99.08%
    Preladenant is a potent competitive antagonist of the human A2A receptor (Ki=1.1 nM) and has >1000-fold selectivity over all other adenosine receptors.
  • HY-10857
    Vipadenant Antagonist 98.28%
    Vipadenant(BIIB-014) is an adenosine A2a antagonist with Ki of 1.3 nM; less potent for A1(Ki=69 nM).
  • HY-13201A
    CGS 21680 Hydrochloride Agonist 98.19%
    CGS 21680 Hydrochloride is a specific adenosine A2A receptor agonist, used for treatment of neurological disease.
  • HY-19532
    ZM241385 Antagonist 98.55%
    ZM 241385 is a novel non-xanthine adenosine receptor antagonist with selectivity for the A2a receptor subtype.
  • HY-10995
    Tozadenant Antagonist 99.01%
    Tozadenant (SYN-115) is an adenosine A2A receptor antagonist.
  • HY-101854
    N6-(2-Phenylethyl)adenosine Agonist
    N6-(2-Phenylethyl)adenosine is a selective A1 adenosine receptor agonist.
  • HY-10888
    Istradefylline Antagonist 98.45%
    Istradefylline is a very potent, selective and orally active adenosine A2A receptor antagonist with Ki of 2.2 nM in experimental models of Parkinson's disease.
  • HY-19533
    SCH 58261 Antagonist 99.38%
    SCH 58261 is the adenosine A2A receptor competitive antagonist. Displays 323-, 53- and 100-fold selectivity over A1, A2B and A3 receptors, respectively.
  • HY-14917
    Capadenoson Agonist 99.38%
    Capadenoson is a selective agonist of adenosine-A1 receptor.
  • HY-A0168
    Regadenoson Agonist >98.0%
    Regadenoson is an A2A adenosine receptor agonist that is a coronary vasodilator that is commonly used in pharmacologic stress testing.
  • HY-B0809
    Theophylline Inhibitor 99.58%
    Theophylline is a methylated xanthine derivative; competitive nonselective phosphodiesterase inhibitor and nonselective adenosine receptor antagonist.
  • HY-13591
    IB-MECA Agonist 98.97%
    IB-MECA is an agonist of the adenosine A3 receptor with EC50 values of 0.11 μM.
  • HY-18687
    N6-[2-(4-Aminophenyl)ethyl]adenosine Agonist
    N6-[2-(4-Aminophenyl)ethyl]adenosine is a potent, non-selective A3 adenosine receptor agonist.
  • HY-B0153A
    Ticlopidine hydrochloride Inhibitor 99.20%
    Ticlopidine hydrochloride is an adenosine diphosphate (ADP) receptor inhibitor against platelet aggregation with IC50 of ~2 μM.
  • HY-12365
    2-Cl-IB-MECA Agonist
    2-Cl-IB-MECA is a selective A3 adenosine receptor agonist (Ki = 0.33 nM). Displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectively.
  • HY-18978
    GR79236 Agonist
    GR79236 is a highly potent and selective adenosine A1 receptor agonist (Ki = 3.1 nM) that has analgesic and anti-inflammatory actions in humans and animals.
  • HY-13201
    CGS 21680 Agonist
    CGS 21680 is a specific adenosine A2A receptor agonist, used for treatment of neurological disease.
  • HY-18939
    N6-Cyclohexyladenosine Agonist
    N6-Cyclohexyladenosine is a selective A1 receptor agonist (EC50 = 8.2 nM).
  • HY-B0128
    Diphylline Antagonist
    Dyphylline acts as an adenosine receptor antagonist and phosphodiesterase inhibitor, which is used in the treatment of respiratory disorders.
  • HY-100032
    PD 117519 Agonist
    PD 117519 is an adenosine agonist.