1. GPCR/G Protein
  2. Adenosine Receptor

SCH 58261 

Cat. No.: HY-19533 Purity: 99.38%
Data Sheet SDS Handling Instructions

SCH 58261 is the adenosine A2A receptor competitive antagonist. Displays 323-, 53- and 100-fold selectivity over A1, A2B and A3 receptors, respectively.

For research use only. We do not sell to patients.
SCH 58261 Chemical Structure

SCH 58261 Chemical Structure

CAS No. : 160098-96-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO $88 In-stock
5 mg $80 In-stock
10 mg $140 In-stock
50 mg $540 In-stock
100 mg $940 In-stock
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

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Description

SCH 58261 is the adenosine A2A receptor competitive antagonist. Displays 323-, 53- and 100-fold selectivity over A1, A2B and A3 receptors, respectively. target: adenosine A2A receptor IC50: 15 nM [3] in vitro: NK cells were cultured in NK cell media and preincubated with or without 1 uM SCH58261 30 min before simulation with indicated concentrations of IL-18 (R & D Systems) and IL-12p70 (Australian Biosearch) in the presence or absence of NECA (1 uM) or CGS-21680 (100 nM).[1] in vivo: it was demonstrated that the selective antagonist of the A2Areceptor, SCH58261, administered i.p. starting from the early minutes after ischemia induction, reduces ischemic brain damage and neurological deficit 24 h thereafter. vehicle-rats received saline with Tween 80 (1 %) administered (i.p.) .SCH58261 (0.01 mg/kg, i.p.), administered twice/day for 7 days [2]

References
Molecular Weight

345.36

Formula

C₁₈H₁₅N₇O

CAS No.

160098-96-4

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 34 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 99.38%

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Product Name:
SCH 58261
Cat. No.:
HY-19533
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