2. Academic Validation
  3. Gabarapl1 mediates androgen-regulated autophagy in prostate cancer

Gabarapl1 mediates androgen-regulated autophagy in prostate cancer

  • Tumour Biol. 2015 Nov;36(11):8727-33. doi: 10.1007/s13277-015-3542-8.
Chong-Wei Xie 1,  You Zhou 1,  Sheng-Lin Liu 1,  Zheng-Yu Fang 1,  Bing Su 2 3,  Wei Zhang 4
Affiliations

Affiliations

  • 1 Biomedical Research Institute, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, No. 1120, Lianhua Road, Futian District, Shenzhen, Guangdong, 518036, China.
  • 2 Xinxiang Key Lab of Translational Cancer Research, The Third Affiliated Hospital, Xinxiang Medical University, Xinxiang, Henan, 453003, China. [email protected].
  • 3 Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, The State University of New York, Buffalo, NY, 14214, USA. [email protected].
  • 4 Biomedical Research Institute, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, No. 1120, Lianhua Road, Futian District, Shenzhen, Guangdong, 518036, China. [email protected].
PMID: 26050226 DOI: 10.1007/s13277-015-3542-8
Abstract

Autophagy plays an important role in prostate Cancer development. It promotes tumor cell survival and was found to be associated with androgen pathway. In the present study, we found that GABA(A) receptor-associated protein like 1 (Gabarapl1), a ubiquitin-like modifier, participates in the regulation of Autophagy. Gabarapl1 is transcriptionally regulated by Androgen Receptor (AR) and has a repressive role in Autophagy. Androgen deprivation downregulates Gabarapl1 in an AR dependent manner, resulting in the increase of Autophagy flux. Elevated Gabarapl1 also represses the proliferation of prostate Cancer cells. In summary, our study provides evidence to show that Gabarapl1 is a mediator involved in androgen-regulated Autophagy process.

Keywords

Androgen; Autophagy; Gabarapl1; Prostate cancer.

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