2. Academic Validation
  3. Ginsenoside Rc from Panax ginseng exerts anti-inflammatory activity by targeting TANK-binding kinase 1/interferon regulatory factor-3 and p38/ATF-2

Ginsenoside Rc from Panax ginseng exerts anti-inflammatory activity by targeting TANK-binding kinase 1/interferon regulatory factor-3 and p38/ATF-2

  • J Ginseng Res. 2017 Apr;41(2):127-133. doi: 10.1016/j.jgr.2016.02.001.
Tao Yu 1 2,  Yanyan Yang 1 2,  Yi-Seong Kwak 3,  Gwan Gyu Song 4,  Mi-Yeon Kim 5,  Man Hee Rhee 6,  Jae Youl Cho 1
Affiliations

Affiliations

  • 1 Department of Genetic Engineering, Sungkyunkwan University, Suwon, Korea.
  • 2 Institute of Translational Medicine, Qingdao University, Qingdao, China.
  • 3 Korean Ginseng Corporation, Central Research Institute, Daejeon, Korea.
  • 4 Division of Rheumatology, Department of Internal Medicine, Korea University Guro Hospital, Seoul, Korea.
  • 5 Department of Bioinformatics and Life Science, Soongsil University, Seoul, Korea.
  • 6 College of Veterinary Medicine, Kyungpook National University, Daegu, Korea.
PMID: 28413316 DOI: 10.1016/j.jgr.2016.02.001
Abstract

Background: Ginsenoside Rc (G-Rc) is one of the major protopanaxadiol-type saponins isolated from Panax ginseng, a well-known medicinal herb with many beneficial properties including Anticancer, anti-inflammatory, antiobesity, and antidiabetic effects. In this study, we investigated the effects of G-Rc on inflammatory responses in vitro and examined the mechanisms of these effects.

Methods: The in vitro inflammation system used lipopolysaccharide-treated macrophages, tumor necrosis factor-α/interferon-γ-treated synovial cells, and HEK293 cells transfected with various inducers of inflammation.

Results: G-Rc significantly inhibited the expression of macrophage-derived cytokines, such as tumor necrosis factor-α and interleukin-1β. G-Rc also markedly suppressed the activation of TANK-binding kinase 1/IκB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling in activated RAW264.7 macrophages, human synovial cells, and HEK293 cells.

Conclusion: G-Rc exerts its anti-inflammatory actions by suppressing TANK-binding kinase 1/IκB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling.

Keywords

Panax ginseng; TANK-binding kinase 1; anti-inflammatory activity; ginsenoside Rc; p38.

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