2. Academic Validation
  3. Combination of 3-methyladenine therapy and Asn-Gly-Arg (NGR)-modified mesoporous silica nanoparticles loaded with temozolomide for glioma therapy in vitro

Combination of 3-methyladenine therapy and Asn-Gly-Arg (NGR)-modified mesoporous silica nanoparticles loaded with temozolomide for glioma therapy in vitro

  • Biochem Biophys Res Commun. 2019 Feb 5;509(2):549-556. doi: 10.1016/j.bbrc.2018.12.158.
Peng Zhang 1,  Menghuan Tang 2,  Qin Huang 1,  Guanjian Zhao 1,  Ning Huang 1,  Xiang Zhang 1,  Ying Tan 3,  Yuan Cheng 4
Affiliations

Affiliations

  • 1 Department of Neurosurgery, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, Chongqing, 400010, China.
  • 2 College of Chemistry and Chemical Engineering, Southwest University, No. 2 Tiansheng Road, Beibei District, Chongqing, 400715, China.
  • 3 Department of Neurosurgery, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, Chongqing, 400010, China; Department of Neurosurgery, Guizhou Provincial People's Hospital, No.52 Zhongshan Road, Guiyang, 550000, China.
  • 4 Department of Neurosurgery, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, Chongqing, 400010, China. Electronic address: [email protected].
PMID: 30600180 DOI: 10.1016/j.bbrc.2018.12.158
Abstract

Mesoporous silica nanoparticles (MSNPs) of a small diameter were loaded with the Anticancer drug temozolomide (TMZ), coated with polydopamine (PDA), and conjugated with Asn-Gly-Arg (NGR) for use in the treatment of glioma. The accumulation of NGR-MSNPs in C6 cells was shown to be higher than that of unmodified MSNPs. Anticancer drugs can cause Autophagy in tumor cells, whereas Autophagy inhibitors can block this reaction and enhance the therapeutic effect of the drugs. In this study, we demonstrated that MSNP-TMZ-PDA-NGR had stronger autophagy- and apoptosis-inducing effects in C6 cells than TMZ alone, and its Anticancer effect was further enhanced when combined with Autophagy inhibition. These results demonstrate that the combination of targeting vehicles and Autophagy inhibitors may have research value in the treatment of gliomas.

Keywords

Apoptosis; Asn-Gly-Arg (NGR); Autophagy inhibition; Glioma; Mesoporous silica nanoparticles.

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