2. GPCR/G Protein Neuronal Signaling
  3. Melanocortin Receptor
  4. ML00253764

ML00253764 is a selective melanocortin receptor 4 (MC4R) antagonist, can induce apoptosis by inhibiting ERK1/2 and Akt phosphorylation, and has anticancer activity.

For research use only. We do not sell to patients.

ML00253764 Chemical Structure

ML00253764 Chemical Structure

CAS No. : 681847-92-7

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 165 In-stock
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10 mM * 1 mL in DMSO USD 165 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

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ML00253764 Related Antibodies

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Description

ML00253764 is a selective melanocortin receptor 4 (MC4R) antagonist, can induce apoptosis by inhibiting ERK1/2 and Akt phosphorylation, and has anticancer activity[1].

In Vitro

ML00253764 (0.001-50 μM, 24 h or 72 h) has significant time- and concentration-dependent inhibitory activity on the proliferation of human glioblastoma cells, and the IC50 value for U-118 cells is 6.56 μM, which can induce U -87 cells apoptosis and show significant inhibition of ERK1/2 phosphorylation in both cell lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ML00253764 Related Antibodies
In Vivo

ML00253764(30 mg/kg, s.c., daily, 34 days) can inhibit inhibit tumor growth in CD nu/nu male mice infected with U-87 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

377.25

Formula

C18H18BrFN2O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC1=C(CCC2=CC(Br)=CC=C2OC)C(C3=NCCN3)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 66.67 mg/mL (176.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6508 mL 13.2538 mL 26.5076 mL
5 mM 0.5302 mL 2.6508 mL 5.3015 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6508 mL 13.2538 mL 26.5076 mL 66.2691 mL
5 mM 0.5302 mL 2.6508 mL 5.3015 mL 13.2538 mL
10 mM 0.2651 mL 1.3254 mL 2.6508 mL 6.6269 mL
15 mM 0.1767 mL 0.8836 mL 1.7672 mL 4.4179 mL
20 mM 0.1325 mL 0.6627 mL 1.3254 mL 3.3135 mL
25 mM 0.1060 mL 0.5302 mL 1.0603 mL 2.6508 mL
30 mM 0.0884 mL 0.4418 mL 0.8836 mL 2.2090 mL
40 mM 0.0663 mL 0.3313 mL 0.6627 mL 1.6567 mL
50 mM 0.0530 mL 0.2651 mL 0.5302 mL 1.3254 mL
60 mM 0.0442 mL 0.2209 mL 0.4418 mL 1.1045 mL
80 mM 0.0331 mL 0.1657 mL 0.3313 mL 0.8284 mL
100 mM 0.0265 mL 0.1325 mL 0.2651 mL 0.6627 mL
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ML00253764 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ML00253764681847-92-7ML 00253764ML-00253764Melanocortin ReceptorMC ReceptorMC4RERK1/2AktapoptosisanticancerInhibitorinhibitorinhibit

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