2. Anti-infection NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Bacterial Reactive Oxygen Species
  4. N-Decanoyl-L-homoserine lactone

N-Decanoyl-L-homoserine lactone  (Synonyms: C10-HSL)

Cat. No.: HY-136409 Purity: 99.43%
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N-decanoyl-L-homoserine lactone (C10-HSL) is a N-acyl-homoserine lactone (AHL) N-decanoyl-L-homoserine lactone can inhibit primary root growth in Arabidopsis. N-decanoyl-L-homoserine lactone triggers a transient and immediate increase in the concentrations of cytosolic free Ca2+ and reactive oxygen species (ROS), increases the activity of mitogen-activated protein kinase 6 (MPK6), and induces nitric oxide (NO) production in Arabidopsis roots.

For research use only. We do not sell to patients.

N-Decanoyl-L-homoserine lactone Chemical Structure

N-Decanoyl-L-homoserine lactone Chemical Structure

CAS No. : 177315-87-6

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5 mg USD 50 In-stock
10 mg USD 85 In-stock
25 mg USD 190 In-stock
50 mg USD 315 In-stock
100 mg USD 505 In-stock
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Based on 1 publication(s) in Google Scholar

N-Decanoyl-L-homoserine lactone Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

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Description

N-decanoyl-L-homoserine lactone (C10-HSL) is a N-acyl-homoserine lactone (AHL) N-decanoyl-L-homoserine lactone can inhibit primary root growth in Arabidopsis. N-decanoyl-L-homoserine lactone triggers a transient and immediate increase in the concentrations of cytosolic free Ca2+ and reactive oxygen species (ROS), increases the activity of mitogen-activated protein kinase 6 (MPK6), and induces nitric oxide (NO) production in Arabidopsis roots[1].

In Vitro

N-decanoyl-L-homoserine lactone (0-75 µM) causes a reduction in primary root growth and promotes lateral root formationin Arabidopsis[1].
N-decanoyl-L-homoserine lactone (0-30 µM) improves cytosolic Ca2+ concentration in wild-type seedlings[1].
Bacterial signal C10-HSL stimulates spore germination of Galactomyces geotrichum by transboundary interaction[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

N-Decanoyl-L-homoserine lactone Related Antibodies
Molecular Weight

255.35

Formula

C14H25NO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCCCC(N[C@@H]1C(OCC1)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (391.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9162 mL 19.5810 mL 39.1619 mL
5 mM 0.7832 mL 3.9162 mL 7.8324 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (9.79 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: 2.5 mg/mL (9.79 mM); Clear solution; Need ultrasonic

    This protocol yields a clear solution of 2.5 mg/mL. If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.9162 mL 19.5810 mL 39.1619 mL 97.9048 mL
5 mM 0.7832 mL 3.9162 mL 7.8324 mL 19.5810 mL
10 mM 0.3916 mL 1.9581 mL 3.9162 mL 9.7905 mL
15 mM 0.2611 mL 1.3054 mL 2.6108 mL 6.5270 mL
20 mM 0.1958 mL 0.9790 mL 1.9581 mL 4.8952 mL
25 mM 0.1566 mL 0.7832 mL 1.5665 mL 3.9162 mL
30 mM 0.1305 mL 0.6527 mL 1.3054 mL 3.2635 mL
40 mM 0.0979 mL 0.4895 mL 0.9790 mL 2.4476 mL
50 mM 0.0783 mL 0.3916 mL 0.7832 mL 1.9581 mL
60 mM 0.0653 mL 0.3263 mL 0.6527 mL 1.6317 mL
80 mM 0.0490 mL 0.2448 mL 0.4895 mL 1.2238 mL
100 mM 0.0392 mL 0.1958 mL 0.3916 mL 0.9790 mL
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N-Decanoyl-L-homoserine lactone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Decanoyl-L-homoserine lactone177315-87-6C10-HSLBacterialReactive Oxygen SpeciesArabidopsis root cellsMPK6mitogen-activated protein kinase 6Cell wallGalactomyces geotrichumSpore germinationTransboundary communicationInhibitorinhibitorinhibit

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