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CTX

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Aminopeptidase (1) Antibiotic (3) Bacterial (7) Beta-lactamase (6) CCR (4) CDK (1) E1/E2/E3 Enzyme (1) Histone Acetyltransferase (1) Interleukin Related (1) MDM-2/p53 (1) Penicillin-binding protein (PBP) (1)
By Research Areas:	Cancer (12) Cardiovascular Disease (2) Endocrinology (2) Infection (7) Inflammation/Immunology (6) Metabolic Disease (3) Neurological Disease (1)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99178

CTX-471	Interleukin Related	Inflammation/Immunology Cancer
CTX-471 is a fully human monoclonal antibody of CD137. CTX-471 has bind affinity for recombinant human, cynomolgus macaque CD137 and mouse CD137 with K_d values of 50 nM, 61 nM and 748 nM, respectively. CTX-471 can be used for the research of immunomodulation and cancer .

HY-144875

CTX-712	CDK	Cancer
CTX-712 is a potent inhibitor of cdc2-like kinase (CLK). CTX-712 inhibits CLK kinase activity, and thus inhibits cancer survival and cancer cell growth. CTX-712 has the potential for the research of cancer disease (extracted from patent JPWO2017188374A1, compound 286) .

HY-136473

CTX-0124143

Others Cancer

CTX-0124143 is a KAT6A inhibitor with a sulfonyl hydrazine skeleton .

CTX-0124143	Others	Cancer
CTX-0124143 is a KAT6A inhibitor with a sulfonyl hydrazine skeleton .

HY-15985

CTX-0294885 2 Publications Verification	Akt	Metabolic Disease Inflammation/Immunology Cancer
CTX-0294885 is a broad spectrum kinase inhibitor that can capture 235 kinases from MDA-MB-231 cells, and can capture all members of the AKT family. CTX-0294885 is a powerful reagent for analysis of kinome signaling networks that can be used for the research of diseases like inflammation, diabetes, and cancer .

HY-15985A

CTX-0294885 hydrochloride 2 Publications Verification	Akt	Metabolic Disease Inflammation/Immunology Cancer
CTX-0294885 hydrochloride is a broad spectrum kinase inhibitor that can capture 235 kinases from MDA-MB-231 cells, and can capture all members of the AKT family. CTX-0294885 hydrochloride is a powerful reagent for analysis of kinome signaling networks that can be used for the research of diseases like inflammation, diabetes, and cancer .

HY-17625

Acebilustat 1 Publications Verification CTX-4430	Aminopeptidase	Inflammation/Immunology
Acebilustat (CTX-4430) is a leukotriene A4 hydrolase inhibitor, used for an oral antiinflammatory agent.

HY-U00442

CTX1 1 Publications Verification	MDM-2/p53 E1/E2/E3 Enzyme	Cancer
CTX1 is a p53 activator that overcomes HdmX-mediated p53 repression. CTX1 exhibits potent anti-cancer activity in a mouse acute myeloid leukemia (AML) model system .

HY-132283

PF-9363 1 Publications Verification CTX-648	Histone Acetyltransferase	Cancer
PF-9363 (CTx-648) is a first-in-class potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer .

HY-149772

Ciguatoxin CTX 3C

Others Neurological Disease Inflammation/Immunology

Ciguatoxin CTX 3C, an immunizing and heterologous hapten, induces a rapid imbalance in neuronal excitability .

*Ciguatoxin CTX* 3C**	Others	Neurological Disease Inflammation/Immunology
Ciguatoxin CTX 3C, an immunizing and heterologous hapten, induces a rapid imbalance in neuronal excitability .

HY-126129

Desacetylcefotaxime	Bacterial	Infection
Desacetylcefotaxime, the in vivo metabolite of Cefotaxime (CTX), possesses significant in vitro antimicrobial activity similar to the parent compound against a variety of aerobic and anaerobic bacteria .

HY-14879A

Avibactam sodium Maximum Cited Publications 56 Publications Verification NXL-104	Beta-lactamase Bacterial Antibiotic	Infection
Avibactam sodium (NXL-104) is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and *CTX-M-15* with IC₅₀s of 8 nM and 5 nM, respectively .

HY-14879B

Avibactam sodium hydrate Maximum Cited Publications 56 Publications Verification NXL-104 hydrate	Beta-lactamase Bacterial Antibiotic	Infection
Avibactam sodium (NXL-104) hydrate is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and *CTX-M-15* with IC₅₀s of 8 nM and 5 nM, respectively .

HY-14879

Avibactam free acid Maximum Cited Publications 56 Publications Verification NXL-104 free acid	Beta-lactamase Bacterial Antibiotic	Infection
Avibactam (NXL-104) free acid is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and *CTX-M-15* with IC₅₀s of 8 nM and 5 nM, respectively .

HY-14879C

Avibactam sodium dihydrate NXL-104 dihydrate
Avibactam sodium (NXL-104) dihydrate is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and *CTX-M-15* with IC₅₀s of 8 nM and 5 nM, respectively .

HY-131349

CCR4-351	CCR	Cancer
CCR4-351 is an orally active, potent and selective CCR4 antagonist. CCR4-351, featuring a novel piperidinyl-azetidine motif, has IC₅₀s of 22 nM and 50 nM in the calcium flux and CTX assay. CCR4-351 has antitumor activity .

HY-131349A

CCR4-351 hydrochloride	CCR	Metabolic Disease Cancer
CCR4-351 hydrochloride is an orally active, potent and selective CCR4 antagonist. CCR4-351 hydrochloride, featuring a novel piperidinyl-azetidine motif, has IC₅₀s of 22 nM and 50 nM in the calcium flux and CTX assay. CCR4-351 hydrochloride has antitumor activity .

HY-109593

BMS-813160 1 Publications Verification	CCR	Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
BMS-813160 is a potent and selective CCR2/5 dual antagonist. BMS-813160 binds with CCR2 and CCR5 with IC₅₀s of 6.2 and 3.6 nM, respectively. BMS-813160 can be used for the research of inflammation .

HY-139745

FPI-1523 sodium	Beta-lactamase Bacterial	Infection
FPI-1523 sodium, a derivative of Avibactam, is a potent β-lactamase inhibitor, with K_ds of 4 nM and 34 nM for *CTX-M-15* and OXA-48, respectively. FPI-1523 sodium also inhibits PBP2, with an IC₅₀ of 3.2 μM. FPI-1523 sodium exhibits considerable antimicrobial activity .

HY-139745A

FPI-1523	Beta-lactamase Bacterial	Infection
FPI-1523, a derivative of Avibactam, is a potent β-lactamase inhibitor, with K_ds of 4 nM and 34 nM for *CTX-M-15* and OXA-48, respectively. FPI-1523 also inhibits PBP2, with an IC₅₀ of 3.2 μM. FPI-1523 exhibits considerable antimicrobial activity .

HY-125836

CCR4 antagonist 2	CCR	Endocrinology Cancer
CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits T_reg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues. CCR4 antagonist 2 (Compound 31) exhibits IC₅₀ values of Ca ²⁺flux and (chemotaxis) CTX are 40 nM and 70 nM, respectively .

HY-139744

FPI-1465	Beta-lactamase Penicillin-binding protein (PBP) Bacterial	Infection
FPI-1465 acts a dual inhibitor of serine-β-Lactamases and Penicillin-binding proteins (PBPs).FPI-1465 inhibits PBP2 (IC₅₀=1.0 µg/mL). FPI-1465 exhibits activity against β-lactamase CTX-M-15 and OXA-48 with K_ds of 0.011 and 5.3 µM, respectively .

Cat. No.	Product Name	Target	Research Area

HY-P1902

*Cardiotoxin Analog (CTX) IV (6-12)* 5 Publications Verification	Peptides	Cardiovascular Disease
Cardiotoxin Analog (CTX) IV (6-12) is a part peptide of Cardiotoxin Analog (CTX) IV. Cardiotoxin analogues IV isolated from the venom of Taiwan Cobra. CTX IV is an unique snake venom cardiotoxin .

HY-P1902A

*Cardiotoxin Analog (CTX) IV (6-12) (TFA)* 5 Publications Verification	Peptides	Others
Cardiotoxin Analog (CTX) IV (6-12) (TFA) is a part peptide of Cardiotoxin Analog (CTX) IV. Cardiotoxin analogues IV isolated from the venom of Taiwan Cobra. CTX IV is an unique snake venom cardiotoxin .

Cat. No.	Product Name	Target	Research Area

HY-P99178

CTX-471	Interleukin Related	Inflammation/Immunology Cancer
CTX-471 is a fully human monoclonal antibody of CD137. CTX-471 has bind affinity for recombinant human, cynomolgus macaque CD137 and mouse CD137 with K_d values of 50 nM, 61 nM and 748 nM, respectively. CTX-471 can be used for the research of immunomodulation and cancer .

HY-P99179

CTX-2026	Inhibitory Antibodies	Cancer
CTX-2026 is a fully human antibody that binds to CD277. CTX-2026 shows an anti-tumor effect on ovarian tumor models. CTX-2026 can be used for the research of cancer .

*Cardiotoxin Analog (CTX) IV (6-12)* 5 Publications Verification	Cardiovascular Disease Natural Products Animals Source classification Disease Research Fields	Others
Cardiotoxin Analog (CTX) IV (6-12) is a part peptide of Cardiotoxin Analog (CTX) IV. Cardiotoxin analogues IV isolated from the venom of Taiwan Cobra. CTX IV is an unique snake venom cardiotoxin .

*Cardiotoxin Analog (CTX) IV (6-12) (TFA)* 5 Publications Verification	Structural Classification Pyrrole Alkaloids Animals Source classification Other Diseases Disease Research Fields	Others
Cardiotoxin Analog (CTX) IV (6-12) (TFA) is a part peptide of Cardiotoxin Analog (CTX) IV. Cardiotoxin analogues IV isolated from the venom of Taiwan Cobra. CTX IV is an unique snake venom cardiotoxin .

Cat. No.	Compare	Product Name	Species	Source

HY-P71459

	*Beta-lactamase CTX-M-1/Bla Protein, E.coli (His)* bla; men1Beta-lactamase CTX-M-1; EC 3.5.2.6; Beta-lactamase MEN-1; Cefotaximase 1	E.coli	E. coli
	Beta-lactamase CTX-M-1/Bla protein is a broad-spectrum beta-lactamase that greatly contributes to antibiotic resistance by hydrolyzing penicillins and cephalosporins (including third-generation drugs). Beta-lactamase CTX-M-1/Bla Protein, E.coli (His) is the recombinant E. coli-derived Beta-lactamase CTX-M-1/Bla protein, expressed by E. coli , with N-His labeled tag. The total length of Beta-lactamase CTX-M-1/Bla Protein, E.coli (His) is 263 a.a., with molecular weight of ~32.2 kDa.


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CTX

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