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Isoforms Recommended:	CYP1

Results for "

CYP1A1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Aryl Hydrocarbon Receptor (6) Autophagy (3) Checkpoint Kinase (Chk) (1) CRFR (1) Cytochrome P450 (29) Endogenous Metabolite (3) ERK (1) Fungal (1) GABA Receptor (2) Isotope-Labeled Compounds (2) NO Synthase (2) Parasite (2) PROTACs (1) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (24) Cardiovascular Disease (1) Infection (3) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (5)

Inhibitors & Agonists

Fluorescent Dye

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D0145

7-Ethoxyresorufin 1 Publications Verification Resorufin ethyl ether	Cytochrome P450 NO Synthase	Others
7-Ethoxyresorufin (Resorufin ethyl ether) is a fluorometric substrate and competitive inhibitor of cytochrome P450, especially *CYP1A1. 7-Ethoxyresorufin also inhibits NO synthase* .

HY-N4205

Tetrahydropiperine	Cytochrome P450	Cancer
Tetrahydropiperine, a cyclohexyl analogue of piperine, is the first natural aryl pentanamide from Piper longum . Tetrahydropiperine (compound 14) inhibits the cytochrome P450 (CYP) isoform CYP1A1/arylhydrocarbon hydroxylase (AHH; IC₅₀=23 µM) .

HY-RS03441

CYP1A1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CYP1A1 Human Pre-designed siRNA Set A contains three designed siRNAs for CYP1A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CYP1A1 Human Pre-designed siRNA Set A CYP1A1 Human Pre-designed siRNA Set A

HY-148595

Antitumor agent-88	Cytochrome P450	Cancer
Antitumor agent-88 exhibits potent antimitotic activity and arrests cell in the G2/M phase. Antitumor agent-88 disrupts the microtubule and the cytoskeleton in CYP1A1-expressing breast cancer cells. Antitumor agent-88 is also a competitive inhibitor of *CYP1A1* (K_i: 1.4 μM) .

HY-N2689

(R)-6',7'-Dihydroxybergamottin (R)-6′,7′-DHB	Cytochrome P450	Cancer
(R)-6',7'-Dihydroxybergamottin ((R)-6′,7′-DHB) is a competitive inhibitor of human and rat *CYP1A1* activity with K_is of 55 μM and 1.72 μM, respectively. (R)-6',7'-Dihydroxybergamottin has the potential for cancer research .

HY-134217

KYN-101	Aryl Hydrocarbon Receptor	Cancer
KYN-101 is a potent, selective and orally active AHR inhibitor. KYN-101 decreases the CYP1A1 mRNA expression. KYN-101 shows anti-cancer activity .

HY-N2625A

Harmalol hydrochloride	Cytochrome P450	Others
Harmalol hydrochloride, a beta carboline alkaloid, presents in several medicinal plants such as Peganum harmala. Harmalol hydrochloride, main metabolite of Harmaline, significantly inhibits the dioxin-mediated induction of CYP1A1 at the transcriptional and posttranslational levels. Harmalol hydrochloride possesses antioxidant and hydroxyl radical-scavenging properties .

HY-N0922

Methysticin

DL-Methysticin; (±)-Methystici
Cytochrome P450 Neurological Disease

Methysticin is a major kavalactone in kava extract to induce CYP1A1.
HY-N2194

Bergamottin

5 Publications Verification

5-Geranoxypsoralen; Bergamotine; Bergaptin

Bergamottin is a potent and competitive CYP1A1 inhibitor with a K_i of 10.703 nM.
HY-101284

DMU2105

DMU2105 is a potent and specific CYP1B1 inhibitor, with IC₅₀s of 10 nM and 742 nM for CYP1B1 and CYP1A1, respectively.
HY-101285

DMU2139

DMU2139 is a potent and specific CYP1B1 inhibitor, with IC₅₀s of 9 nM and 795 nM for CYP1B1 and CYP1A1, respectively.

Methysticin DL-Methysticin; (±)-Methystici	Cytochrome P450	Neurological Disease
Methysticin is a major kavalactone in kava extract to induce *CYP1A1*.

Bergamottin 5 Publications Verification 5-Geranoxypsoralen; Bergamotine; Bergaptin
Bergamottin is a potent and competitive *CYP1A1* inhibitor with a K_i of 10.703 nM.

DMU2105
DMU2105 is a potent and specific *CYP1B1* inhibitor, with IC₅₀s of 10 nM and 742 nM for CYP1B1 and CYP1A1, respectively.

DMU2139
DMU2139 is a potent and specific *CYP1B1* inhibitor, with IC₅₀s of 9 nM and 795 nM for CYP1B1 and CYP1A1, respectively.

HY-N8382

Chalepensin	Cytochrome P450	Neurological Disease
Chalepensin, a furanocoumarin, is a competitive CYP2A6 inhibitor. Chalepensin also inhibits human CYP1A1, CYP1A2, CYP2A13, CYP2C9, CYP2D6, CYP2E1, and CYP3A4 to different extents .

HY-103223

Phortress

NSC 710305
Cytochrome P450 Cancer

Phortress is a high affinity AhR ligand that elicits antitumor activity by inducing transcription of CYP1A1 .

Phortress NSC 710305	Cytochrome P450	Cancer
Phortress is a high affinity AhR ligand that elicits antitumor activity by inducing transcription of CYP1A1 .

HY-N0382

Galangin Maximum Cited Publications 9 Publications Verification Norizalpinin; 3,5,7-Trihydroxyflavone	Cytochrome P450 Autophagy	Cancer
Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor. Galangin (Norizalpinin) also shows inhibition of *CYP1A1* activity.

HY-128920

Phortress free base	Cytochrome P450	Cancer
Phortress free base (NSC 710305) is a P450 *CYP1A1*-activated antitumor prodrug with antitumor activity . Phortress free base leads to DNA damage and cell cycle arrest .

HY-148592

Antitumor agent-87	Cytochrome P450	Cancer
Antitumor agent-87 is a potent antitumor agent. Antitumor agent-87 shows a high affinity for CYP1A1 with a K_i value of 0.23 µM. Antitumor agent-87 shows antiproliferative activity. Antitumor agent-87 induces cell cycle arrest at the G2/M phase. Antitumor agent-87 show antitumoral activity .

HY-B2015

Carbosulfan

Cytochrome P450 Parasite Infection

Carbosulfan inhibited relatively potently CYP3A4 and moderately CYP1A1/2 and CYP2C19 in pooled HLM (human livers).

Carbosulfan	Cytochrome P450 Parasite	Infection
Carbosulfan inhibited relatively potently CYP3A4 and moderately CYP1A1/2 and CYP2C19 in pooled HLM (human livers).

HY-118216

Bitertanol Biloxazol	Fungal Cytochrome P450	Infection
Bitertanol (Biloxazol) is a potent antifungal agent. Bitertanol also is an *CYP1A1, CYP2B, and CYP3A* inducer in vivo and an *CYP1A* inhibitor in vitro .

HY-N6264

26-Deoxyactein	Aryl Hydrocarbon Receptor ERK	Metabolic Disease
26-Deoxyactein is a constituent isolated from Cimicifuga racemosa, prevents TCDD-induced osteoblasts damage. 26-Deoxyactein inhibits increased AhR, CYP1A1 and ERK levels .

HY-N0382S

Galangin-13C3	Isotope-Labeled Compounds Cytochrome P450 Autophagy	Cancer
Galangin- ¹³C₃ is the ¹³C-labeled Galangin. Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor. Galangin (Norizalpinin) also shows inhibition of CYP1A1 activity.

HY-14225

BMS-764459	CRFR Cytochrome P450	Neurological Disease
BMS-764459 is a CRF1 antagonist. BMS-764459 can be used for the research of neurological disorders such as depression and anxiety. BMS-764459 is also an atypical *CYP1A1* inducer .

HY-N0382R

Galangin (Standard) Norizalpinin (Standard); 3,5,7-Trihydroxyflavone (Standard)	Cytochrome P450 Autophagy	Cancer
Galangin (Standard) is the analytical standard of Galangin. This product is intended for research and analytical applications. Galangin (Norizalpinin) is?an?agonist/antagonist?of the?arylhydrocarbon?receptor. Galangin (Norizalpinin) also shows inhibition of *CYP1A1* activity.

HY-152079

CYP1B1-IN-3	Cytochrome P450	Cancer
CYP1B1-IN-3 is a potent and selective *CYP1B1* inhibitor with IC₅₀ values of 6.6, 347.3, >10000 nM for CYP1B1, CYP1A1, CYP1A2, respectively. CYP1B1-IN-3 inhibits cell migration and invasion. CYP1B1-IN-3 inhibits P-gp, AKT/ERK, FAK/SRC, and EMT pathways .

HY-B2015S

Carbosulfan-d18	Cytochrome P450 Parasite	Infection
Carbosulfan-d₁₈ is the deuterium labeled Carbosulfan. Carbosulfan inhibited relatively potently CYP3A4 and moderately CYP1A1/2 and CYP2C19 in pooled HLM (human livers). Carbosulfan activation is predominantly catalyzed in humans by CYP3A4.

HY-D0145S

7-Ethoxyresorufin-d5 Resorufin ethyl ether-d₅	Isotope-Labeled Compounds Cytochrome P450 NO Synthase	Others
7-Ethoxyresorufin-d₅ is deuterium labeled 7-Ethoxyresorufin. 7-Ethoxyresorufin (Resorufin ethyl ether) is a fluorometric substrate and competitive inhibitor of cytochrome P450, especially CYP1A1. 7-Ethoxyresorufin also inhibits NO synthase[1][2].

HY-19340

TMS 5 Publications Verification (E)-2,3',4,5'-tetramethoxystilbene	Cytochrome P450	Cancer
TMS ((E)-2,3',4,5'-tetramethoxystilbene) is a selective and competitive *CYP1B1* inhibitor with an IC₅₀ of 6 nM and a K_i value of 3 nM. TMS shows a lesser extent inhibitory effect on CYP1A1 (IC₅₀=300 nM) and CYP1A2 (IC₅₀=3.1 μM). TMS is a methylated derivative of resveratrol and has anti-cancer activity .

HY-124421

5F-203 NSC-703786	Aryl Hydrocarbon Receptor	Others
5F-203 (NSC-703786) is a cytotoxic molecule that forms DNA adducts and cell cycle arrest. 5F-203 induces aryl hydrocarbon receptor (AhR) signaling and elevates expression of CYP1A1. 5F-203 also increases the levels of reactive oxygen species as well as activates JNK, ERK, and p38 .

HY-B0822

Fipronil
Fipronil is a broad-spectrum insecticide effective against Lepidoptera species as well as thrips, locusts, ants, cockroaches, fleas and ticks. Fipronil selectively inhibits GABA receptor with IC₅₀s of 30 nM and 1600 nM for cockroach and rat GABA receptors, respectively. Glutamate-gated chloride channels (GluCls), which are present in cockroaches but not in mammals, are sensitive to the blocking effect of Fipronil. Fipronil also induces apoptosis in HepG2 cells and promotes the expression of CYP1A1 and CYP3A4 mRNA in human hepatocytes .

HY-B0822R

Fipronil (Standard)	GABA Receptor Cytochrome P450 Apoptosis	Neurological Disease
Fipronil (Standard) is the analytical standard of Fipronil. This product is intended for research and analytical applications. Fipronil is a broad-spectrum insecticide effective against Lepidoptera species as well as thrips, locusts, ants, cockroaches, fleas and ticks. Fipronil selectively inhibits GABA receptor with IC₅₀s of 30 nM and 1600 nM for cockroach and rat GABA receptors, respectively. Glutamate-gated chloride channels (GluCls), which are present in cockroaches but not in mammals, are sensitive to the blocking effect of Fipronil. Fipronil also induces apoptosis in HepG2 cells and promotes the expression of CYP1A1 and CYP3A4 mRNA in human hepatocytes .

HY-B0822S1

Fipronil-13C6	GABA Receptor Cytochrome P450	Inflammation/Immunology
Fipronil- ¹³C₆ is the ¹³C-labeled Fipronil. Fipronil is an insecticide that acts as a selective antagonist of insect GABA receptors (IC50s = 30 nM and 1,600 nM for cockroach and rat receptors, respectively). Fipronil also inhibits desensitizing and non-desensitizing glutamate-induced chloride currents in cockroach neurons (IC50s = 800 nM and 10 nM, respectively). Fipronil induces activity of the cytochrome P450 (CYP) isoforms CYP1A1/2, CYP2B1/2, and CYP3A1/2 in isolated rat liver microsomes.

HY-157942

CYP1B1-IN-7	Cytochrome P450	Cancer
CYP1B1-IN-7 (compound 2a) is a selective inhibitor of CYP1B1 (IC₅₀: 75 nM). CYP1B1-IN-7 also reverses resistance (IC₅₀: 29 μM) and exhibits cytotoxicity in the CYP1B1-overexpressing MCF-7 cell line that is resistant to Docetaxel (HY-B0011) .

HY-162051

CYP1B1-IN-6	Cytochrome P450	Cancer
CYP1B1-IN-6 (compound 19) is a fluorescence molecular probes which inhibits *CYP1B1* activity. CYP1B1-IN-6 can identify tumor sites in fluorescence imaging and photoacoustic imaging modes .

HY-146393

*PROTAC CYP1B1* degrader-1**	PROTACs Cytochrome P450	Cancer
PROTAC CYP1B1 degrader-1 (Compound 6C), a α-naphthoflavone chimera derivative, is able to eliminate cytochrome P450 (CYP)1B1-mediated agent resistance via targeted *CYP1B1* degradation, with IC₅₀s of 95.1 and 9838.6 nM for CYP1B1 and CYP1A2, respectively. PROTAC CYP1B1 degrader-1 can be used for the research of CYP1B1-overexpressing prostate cancer .

HY-152118

CYP1B1-IN-4	Cytochrome P450	Cancer
CYP1B1-IN-4 is a 2,4-diarylthiazole compound with selectively *CYP1B1* inhibition (IC₅₀=0.2 nM). CYP1B1-IN-4 has little cytotoxicity and high stability in both human and rat liver microsomes .

HY-150557

CYP1B1-IN-1

Cytochrome P450 Cancer

CYP1B1-IN-1 (Compound 9e) is a selective cytochrome P450 1B1 (CYP1B1) inhibitor with an IC₅₀ of 0.49 nM .
HY-150558

CYP1B1-IN-2

Cytochrome P450 Cancer

CYP1B1-IN-2 (compound 9j) is a potent and selective CYP1B1 (cytochrome P450 1B1) inhibitor, with an IC₅₀ of 0.52 nM .
HY-152196

CYP1B1-IN-5

Cytochrome P450 Cancer

CYP1B1-IN-5 (Compound 6q) is a potent and selective cytochrome P450 1B1 (CYP1B1) inhibitor with an IC₅₀ of 4.7 nM .

CYP1B1-IN-1	Cytochrome P450	Cancer
CYP1B1-IN-1 (Compound 9e) is a selective cytochrome P450 1B1 (CYP1B1) inhibitor with an IC₅₀ of 0.49 nM .

CYP1B1-IN-2	Cytochrome P450	Cancer
CYP1B1-IN-2 (compound 9j) is a potent and selective *CYP1B1* (cytochrome P450 1B1) inhibitor, with an IC₅₀ of 0.52 nM .

CYP1B1-IN-5	Cytochrome P450	Cancer
CYP1B1-IN-5 (Compound 6q) is a potent and selective cytochrome P450 1B1 (CYP1B1) inhibitor with an IC₅₀ of 4.7 nM .

HY-RS03443

CYP1B1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CYP1B1 Human Pre-designed siRNA Set A contains three designed siRNAs for CYP1B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CYP1B1 Human Pre-designed siRNA Set A CYP1B1 Human Pre-designed siRNA Set A

HY-135829

BAY 2416964	Aryl Hydrocarbon Receptor	Cancer
BAY 2416964 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1, example 192, has an IC₅₀ of 341 nM. BAY 2416964 has the potential for solid tumors treatment .

HY-112628

CAY10464 AHR antagonist 7	Aryl Hydrocarbon Receptor	Cancer
CAY10464 (AHR antagonist 7; compound 4j) is a selective and high-affinity aryl hydrocarbon receptor (AhR) antagonist with a K_i of 1.4 nM .

HY-101284A

(E/Z)-DMU2105

Others Cancer

(E/Z)-DMU2105 is the E/Z isomer of DMU2105 (HY-101284). DMU2105 is a CYP1B1 inhibitor .

(E/Z)-DMU2105	Others	Cancer
(E/Z)-DMU2105 is the E/Z isomer of DMU2105 (HY-101284). DMU2105 is a CYP1B1 inhibitor .

HY-N1082

Visnagin	Others	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Visnagin, an antioxidant furanocoumarin derivative, possess anti-inflammatory and analgesic properties. Visnagin has substantial potential to prevent Cerulein induced acute pancreatitis (AP). Visnagin possess promising vasodilator effects in vascular smooth muscles .

HY-Y0110

2-Naphthol

Endogenous Metabolite Others

2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2).

2-Naphthol	Endogenous Metabolite	Others
2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2).

HY-N10344

Glucoarabin	Others	Cancer
Glucoarabin is a bioactive glucosinolate. In Hepa1c1c7 cells, hydrolyzed Glucoarabin (hGSL 9) upregulates the phase II detoxification enzyme quinone reductase (NQO1), with no effect on cytochrome P450 (CYP) 1A1 activity .

HY-Y0110S

2-Naphthol-d8	Endogenous Metabolite	Others
2-Naphthol-d₈ is the deuterium labeled 2-Naphthol[1]. 2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2)[2].

HY-Y0110S1

2-Naphthol-d7	Endogenous Metabolite	Others
2-Naphthol-d₇ is the deuterium labeled 2-Naphthol[1]. 2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2)[2].

HY-117102

ANI-7	Aryl Hydrocarbon Receptor Checkpoint Kinase (Chk)	Cancer
ANI-7 is an activator of aryl hydrocarbon receptor (AhR) pathway. ANI-7 inhibits the growth of multiple cancer cells, and potently and selectively inhibits the growth of MCF-7 breast cancer cells with a GI₅₀ of 0.56 μM. ANI-7 induces CYP1-metabolizing mono-oxygenases by activating AhR pathway, and also induces DNA damage, checkpoint Kinase 2 (Chk2) activation, S-phase cell cycle arrest, and cell death in sensitive breast cancer cell lines .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N4205

Tetrahydropiperine	Alkaloids Piperidine Alkaloids Classification of Application Fields Source classification Piperaceae Plants Disease Research Fields Piper nigrum Linn. Cancer	Cytochrome P450
Tetrahydropiperine, a cyclohexyl analogue of piperine, is the first natural aryl pentanamide from Piper longum . Tetrahydropiperine (compound 14) inhibits the cytochrome P450 (CYP) isoform CYP1A1/arylhydrocarbon hydroxylase (AHH; IC₅₀=23 µM) .

HY-N2625A

Harmalol hydrochloride	Alkaloids Structural Classification Monophenols Classification of Application Fields Zygophyllaceae Source classification Peganum harmala Linn. Other Diseases Phenols Pyridine Alkaloids Plants Disease Research Fields	Cytochrome P450
Harmalol hydrochloride, a beta carboline alkaloid, presents in several medicinal plants such as Peganum harmala. Harmalol hydrochloride, main metabolite of Harmaline, significantly inhibits the dioxin-mediated induction of CYP1A1 at the transcriptional and posttranslational levels. Harmalol hydrochloride possesses antioxidant and hydroxyl radical-scavenging properties .

HY-N2689

(R)-6',7'-Dihydroxybergamottin (R)-6′,7′-DHB	Structural Classification Natural Products Citrus × aurantium Linnaeus Source classification Rutaceae Plants	Cytochrome P450
(R)-6',7'-Dihydroxybergamottin ((R)-6′,7′-DHB) is a competitive inhibitor of human and rat *CYP1A1* activity with K_is of 55 μM and 1.72 μM, respectively. (R)-6',7'-Dihydroxybergamottin has the potential for cancer research .

HY-N0922

Methysticin DL-Methysticin; (±)-Methystici	Structural Classification Natural Products other families Source classification Plants	Cytochrome P450
Methysticin is a major kavalactone in kava extract to induce *CYP1A1*.

HY-N8382

Chalepensin	Structural Classification Natural Products Haloxylon ammodendron (C. A. Mey.) Bunge Source classification Amaranthaceae Plants	Cytochrome P450
Chalepensin, a furanocoumarin, is a competitive CYP2A6 inhibitor. Chalepensin also inhibits human CYP1A1, CYP1A2, CYP2A13, CYP2C9, CYP2D6, CYP2E1, and CYP3A4 to different extents .

HY-N0382

Galangin 5+ Cited Publications Norizalpinin; 3,5,7-Trihydroxyflavone	Flavonols Flavonoids Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Alpinia officinarum Hance Plants Disease Research Fields Cancer Zingiberaceae	Cytochrome P450 Autophagy
Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor. Galangin (Norizalpinin) also shows inhibition of *CYP1A1* activity.

HY-N6264

26-Deoxyactein	Triterpenes Classification of Application Fields Terpenoids Source classification Ranunculaceae Metabolic Disease Plants Cimicifuga foetida Linn. Cimicifuga racemosa (L.) Nutt. Disease Research Fields	Aryl Hydrocarbon Receptor ERK
26-Deoxyactein is a constituent isolated from Cimicifuga racemosa, prevents TCDD-induced osteoblasts damage. 26-Deoxyactein inhibits increased AhR, CYP1A1 and ERK levels .

HY-N0382R

Galangin (Standard) Norizalpinin (Standard); 3,5,7-Trihydroxyflavone (Standard)	Structural Classification Flavonoids Classification of Application Fields Source classification Phenols Alpinia officinarum Hance Plants Disease Research Fields Cancer Zingiberaceae	Cytochrome P450 Autophagy
Galangin (Standard) is the analytical standard of Galangin. This product is intended for research and analytical applications. Galangin (Norizalpinin) is?an?agonist/antagonist?of the?arylhydrocarbon?receptor. Galangin (Norizalpinin) also shows inhibition of *CYP1A1* activity.

HY-N1082

Visnagin	Cardiovascular Disease Classification of Application Fields Neurological Disease Ketones, Aldehydes, Acids Source classification Artemisia cana Pursh Plants Umbelliferae Disease Research Fields	Others
Visnagin, an antioxidant furanocoumarin derivative, possess anti-inflammatory and analgesic properties. Visnagin has substantial potential to prevent Cerulein induced acute pancreatitis (AP). Visnagin possess promising vasodilator effects in vascular smooth muscles .

HY-Y0110

2-Naphthol	Monophenols Microorganisms Classification of Application Fields Source classification Other Diseases Phenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2).

HY-N10344

Glucoarabin	Structural Classification Natural Products Classification of Application Fields Source classification Camelina sativa (L.) Crantz Glucosinolates Plants Brassicaceae Disease Research Fields Cancer	Others
Glucoarabin is a bioactive glucosinolate. In Hepa1c1c7 cells, hydrolyzed Glucoarabin (hGSL 9) upregulates the phase II detoxification enzyme quinone reductase (NQO1), with no effect on cytochrome P450 (CYP) 1A1 activity .

Cat. No.	Product Name	Chemical Structure

HY-N0382S

Galangin-13C3
Galangin- ¹³C₃ is the ¹³C-labeled Galangin. Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor. Galangin (Norizalpinin) also shows inhibition of CYP1A1 activity.

HY-B2015S

Carbosulfan-d18
Carbosulfan-d₁₈ is the deuterium labeled Carbosulfan. Carbosulfan inhibited relatively potently CYP3A4 and moderately CYP1A1/2 and CYP2C19 in pooled HLM (human livers). Carbosulfan activation is predominantly catalyzed in humans by CYP3A4.

HY-D0145S

7-Ethoxyresorufin-d5
7-Ethoxyresorufin-d₅ is deuterium labeled 7-Ethoxyresorufin. 7-Ethoxyresorufin (Resorufin ethyl ether) is a fluorometric substrate and competitive inhibitor of cytochrome P450, especially CYP1A1. 7-Ethoxyresorufin also inhibits NO synthase[1][2].

HY-B0822S1

Fipronil-13C6

Fipronil- ¹³C₆ is the ¹³C-labeled Fipronil. Fipronil is an insecticide that acts as a selective antagonist of insect GABA receptors (IC50s = 30 nM and 1,600 nM for cockroach and rat receptors, respectively). Fipronil also inhibits desensitizing and non-desensitizing glutamate-induced chloride currents in cockroach neurons (IC50s = 800 nM and 10 nM, respectively). Fipronil induces activity of the cytochrome P450 (CYP) isoforms CYP1A1/2, CYP2B1/2, and CYP3A1/2 in isolated rat liver microsomes.

HY-Y0110S

2-Naphthol-d8
2-Naphthol-d₈ is the deuterium labeled 2-Naphthol[1]. 2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2)[2].

HY-Y0110S1

2-Naphthol-d7
2-Naphthol-d₇ is the deuterium labeled 2-Naphthol[1]. 2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2)[2].

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