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Results for "

FMK

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (1) Antibiotic (1) Apoptosis (9) Autophagy (1) Caspase (19) Cathepsin (6) Fluorescent Dye (2) Influenza Virus (1) Keap1-Nrf2 (1) MALT1 (2) Necroptosis (2) Proteasome (1) Ribosomal S6 Kinase (RSK) (3) RIP kinase (1) SARS-CoV (2)
By Research Areas:	Cancer (32) Infection (4) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (3)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-52101A

FMK

3 Publications Verification

Ribosomal S6 Kinase (RSK) Cancer

FMK is a an irreversible RSK2 kinase inhibitor, that covalently modifies the C-terminal kinase domain of RSK.
HY-52101C

FMK-MEA

Ribosomal S6 Kinase (RSK) Cancer

FMK-MEA is a potent and selective p90 Ribosomal S6 Kinase (RSK) inhibitor.
HY-100522

FMK 9a

2 Publications Verification

Autophagy Cancer

FMK 9a is an autophagin-1 inhibitor with IC₅₀ values of 80 and 73 μM in FRET and LRA assay.

*FMK* 3 Publications Verification	Ribosomal S6 Kinase (RSK)	Cancer
FMK is a an irreversible RSK2 kinase inhibitor, that covalently modifies the C-terminal kinase domain of RSK.

FMK-MEA	Ribosomal S6 Kinase (RSK)	Cancer
FMK-MEA is a potent and selective p90 Ribosomal S6 Kinase (RSK) inhibitor.

FMK 9a 2 Publications Verification	Autophagy	Cancer
FMK 9a is an autophagin-1 inhibitor with IC₅₀ values of 80 and 73 μM in FRET and LRA assay.

HY-101297

Z-IETD-FMK 35+ Cited Publications Z-IE(OMe)TD(OMe)-FMK	Caspase	Cancer
Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a selective and cell permeable caspase-8 inhibitor . Z-IETD-FMK is also a granzyme B inhibitor .

HY-16658

Z-VAD(OMe)-FMK 150+ Cited Publications Z-Val-Ala-Asp(OMe)-FMK	Caspase	Cancer
Z-VAD(OMe)-FMK (Z-Val-Ala-Asp(OMe)-FMK) is a cell-permeable and irreversible pan-caspase inhibitor . Z-VAD(OMe)-FMK is an ubiquitin carboxy-terminal hydrolase L1 (UCHL1) inhibitor. Z-VAD(OMe)-FMK irreversibly modifies UCHL1 by targeting the active site of UCHL1 .

HY-141867

Z-FF-FMK Z-Phe-Phe-FMK	Cathepsin	Neurological Disease
Z-FF-FMK is a selective cathepsin-L inhibitor. Z-FF-FMK can prevent β-amyloid to induce apoptotic changes such as activation of caspase-3, cleavage of the DNA repair enzyme, poly-ADP ribose polymerase, and DNA fragmentation .

HY-153614

Ac-VLPE-FMK Ac-Val-Leu-Pro-Glu(OMe)-CH2F	Cathepsin	Cancer
Ac-VLPE-FMK, a tetrapeptidyl mono-fluoromethyl ketone (m-FMK), is a Cat-B and Cat-L inhibitor. Ac-VLPE-FMK can be used for the research of cancer aggressiveness .

HY-P1009

Z-YVAD-FMK

10+ Cited Publications

Caspase Cancer

Z-YVAD-FMK is a cell-permeable caspase-1 and -4 inhibitor with anti-inflammatory and anti-tumor activities .

Z-YVAD-FMK 10+ Cited Publications	Caspase	Cancer
Z-YVAD-FMK is a cell-permeable caspase-1 and -4 inhibitor with anti-inflammatory and anti-tumor activities .

HY-P5975

Z-Leu-Leu-Leu-fluoromethyl ketone Z-LLL-FMK	Cathepsin SARS-CoV	Infection
Z-Leu-Leu-Leu-fluoromethyl ketone (Z-LLL-FMK) is a cysteine protease inhibitor. Z-Leu-Leu-Leu-fluoromethyl ketone inhibits SARS infection. Z-Leu-Leu-Leu-fluoromethyl ketone also protects mice against a T. crassiceps challenge .

HY-P0109A

Z-FA-FMK 2 Publications Verification (1S)-Z-FA-FMK	SARS-CoV Cathepsin Apoptosis Caspase	Infection Cancer
Z-FA-FMK ((1S)-Z-FA-FMK) is a potent Cathepsin B and L inhibitor. Z-FA-FMK blocks the induction of DEVDase activity, DNA fragmentation, and externalization of phosphatidylserine by selective synthetic retinoid-related molecules (RRMs). Z-FA-FMK inhibits apoptosis. Z-FA-FMK inhibits caspase activity and selectively inhibits recombinant effector caspases 2, -3, -6, and -7. Z-FA-FMK is a viral inhibitor. Z-FA-FMK inhibits reovirus replication in a susceptible host .

HY-P1007

Z-VEID-FMK Z-VE(OMe)ID(OMe)-FMK	Caspase Apoptosis	Cancer
Z-VEID-FMK (Z-VE(OMe)ID(OMe)-FMK) is a selective and irreversible caspase-6 peptide inhibitor. Z-VEID-FMK alleviates the S-(+)-ketamine-induced augmentation of caspase-6 activity, DNA fragmentation, and cell apoptosis .

HY-P1008

Z-VDVAD-FMK

Z-VD(OMe)VAD(OMe)-FMK
Caspase Cancer

Z-VDVAD-FMK is a special inhibitor of caspase-2. Z-VDVAD-FMK produces a reduction in Lovastatin-induced apoptosis .
HY-P1008A

Z-VDVA-(DL-Asp)-FMK

Z-VD(OMe)VAD(OMe)-(DL-Asp)-FMK
Caspase Cancer

Z-VDVA-(DL-Asp)-FMK is a Z-VDVAD-FMK derivative. Z-VDVAD-FMK (HY-P1008) is a special inhibitor of caspase-2 .

Z-VDVAD-FMK Z-VD(OMe)VAD(OMe)-FMK	Caspase	Cancer
Z-VDVAD-FMK is a special inhibitor of caspase-2. Z-VDVAD-FMK produces a reduction in Lovastatin-induced apoptosis .

Z-VDVA-(DL-Asp)-FMK Z-VD(OMe)VAD(OMe)-(DL-Asp)-FMK	Caspase	Cancer
Z-VDVA-(DL-Asp)-FMK is a Z-VDVAD-FMK derivative. Z-VDVAD-FMK (HY-P1008) is a special inhibitor of caspase-2 .

HY-P0111

Z-WEHD-FMK 2 Publications Verification Z-WE(OMe)HD(OMe)-FMK	Caspase Cathepsin	Cancer
Z-WEHD-FMK is a potent, cell-permeable and irreversible caspase-1/5 inhibitor. Z-WEHD-FMK also exhibits a robust inhibitory effect on cathepsin B activity (IC₅₀=6 μM). Z-WEHD-FMK can be used to investigate cells for evidence of apoptosis .

HY-128707

Z-LEVD-FMK

1 Publications Verification

Caspase Apoptosis Cancer

Z-LEVD-FMK is a cell-permeable caspase-4 inhibitor. Z-LEVD-FMK blocks ER stress-induced apoptosis in cancer cells .

Z-LEVD-FMK 1 Publications Verification	Caspase Apoptosis	Cancer
Z-LEVD-FMK is a cell-permeable caspase-4 inhibitor. Z-LEVD-FMK blocks ER stress-induced apoptosis in cancer cells .

HY-16658B

Z-VAD-FMK Maximum Cited Publications 297 Publications Verification Z-VAD(OH)-FMK	Caspase Apoptosis	Cancer
Z-VAD-FMK (Z-VAD(OH)-FMK) is a well-know pan caspase inhibitor, which does not inhibit ubiquitin carboxy-terminal hydrolase L1 (UCHL1) activity even at concentrations as high as 440 μM .

HY-13229

BOC-D-FMK 5 Publications Verification	Caspase Apoptosis	Cancer
Boc-D-FMK is a cell-permeable, irreversible and broad spectrum caspase inhibitor. Boc-D-FMK inhibits apoptosis stimulated by TNF-α with an IC₅₀ of 39 µM.

HY-P5122

Z-LEED-FMK

Caspase Inflammation/Immunology

Z-LEED-FMK is a caspase-13 and caspase-4 inhibitor. Z-LEED-FMK also inhibits caspase-1 processing in S. typhimurium-infected macrophages .

Z-LEED-FMK	Caspase	Inflammation/Immunology
Z-LEED-FMK is a caspase-13 and caspase-4 inhibitor. Z-LEED-FMK also inhibits caspase-1 processing in S. typhimurium-infected macrophages .

HY-P1010

Z-LEHD-FMK 5+ Cited Publications	Caspase Apoptosis	Neurological Disease Cancer
Z-LEHD-FMK is a selective and irreversible inhibitor of caspase-9, protects against lethal reperfusion injury and attenuates apoptosis. Z-LEHD-FMK exhibits the neuroprotective effect in a rat model of spinal cord trauma .

HY-120231

Z-VRPR-FMK	MALT1	Cancer
Z-VRPR-FMK is an irreversible MALT1 protein inhibitor. Z-VRPR-FMK inhibits the growth and invasion of diffuse large B-cell lymphoma by inhibiting MALT1-induced NF-κB activation and MMP expression .

HY-125305

Z-AEVD-FMK

ADC Linker Cancer

Z-AEVD-FMK is a cleavable ADC linker for the synthesis of antibody active molecule conjugates (ADCs).

Z-AEVD-FMK	ADC Linker	Cancer
Z-AEVD-FMK is a cleavable ADC linker for the synthesis of antibody active molecule conjugates (ADCs).

HY-P1010A

*Z-LEHD-FMK* TFA**	Caspase Apoptosis	Neurological Disease Cancer
Z-LEHD-FMK TFA is a selective and irreversible inhibitor of caspase-9, protects against lethal reperfusion injury and attenuates apoptosis. Z-LEHD-FMK TFA exhibits the neuroprotective effect in a rat model of spinal cord trauma .

HY-138203

Z-LE(OMe)TD(OMe)-FMK

Caspase Apoptosis Cancer

Z-LE(OMe)TD(OMe)-FMK is a selective caspase-8 inhibitor. Z-LE(OMe)TD(OMe)-FMK can inhibit cell apoptosis .
HY-12466

Z-DEVD-FMK

65+ Cited Publications

Caspase Cancer

Z-DEVD-FMK is a specific and irreversible caspase-3 inhibitor with an IC₅₀ of 18 μM .

Z-LE(OMe)TD(OMe)-FMK	Caspase Apoptosis	Cancer
Z-LE(OMe)TD(OMe)-FMK is a selective caspase-8 inhibitor. Z-LE(OMe)TD(OMe)-FMK can inhibit cell apoptosis .

Z-DEVD-FMK 65+ Cited Publications	Caspase	Cancer
Z-DEVD-FMK is a specific and irreversible caspase-3 inhibitor with an IC₅₀ of 18 μM .

HY-D1432

FITC-C6-DEVD-FMK	Fluorescent Dye	Cancer
FITC-C6-DEVD-FMK, a fluorescently labeled caspase-3 inhibitor, can be used for detection of active caspase-3 in mammalian cells undergoing apoptosis. FITC-C6-DEVD-FMK provides a convenient means for sensitive detection of activated caspase-3 in living cells. Z-DEVD-FMK is a specific caspase-3 inhibitor .

HY-D1433

FITC-C6-LEHD-FMK	Fluorescent Dye	Cancer
FITC-C6-LEHD-FMK, a fluorescently labeled caspase-9 inhibitor, can be used for detection of active caspase-9 in mammalian cells undergoing apoptosis. FITC-C6-LEHD-FMK provides a convenient means for sensitive detection of activated caspase-9 in living cells. Z-LEHD-FMK is a specific caspase-9 inhibitor .

HY-136750

Z-LLY-FMK Calpain Inhibitor IV	Apoptosis Proteasome	Cancer
Z-LLY-FMK (Calpain Inhibitor IV) is a calpain inhibitor, involved in apoptosis of many cell systems. Z-LLY-FMK inhibits the intestine apoptosis after common bile duct ligation .

HY-P1407

*Z-VRPR-FMK* TFA** VRPR	MALT1 Influenza Virus	Infection Cancer
Z-VRPR-FMK (TFA) (VRPR), a tetrapeptide, is a selective and irreversible MALT1 (Mucosa-associated lymphoid tissue lymphoma translocation protein 1) inhibitor. Z-VRPR-FMK (TFA) can protect against influenza A virus (IAV) infection .

HY-P0109

(S,S)-Z-FA-FMK
(S,S)-Z-FA-FMK is a cell-permeable, irreversible cathepsin B inhibitor. (S,S)-Z-FA-FMK blocks LPS-induced production of IL-1α and IL-1β. (S,S)-Z-FA-FMK can be used as a negative control for caspase-1 and caspase-2 inhibitors because it lacks an aspartic acid residue at the P1 position .

HY-100894

Biotin-VAD-FMK

Caspase Cancer

Biotin-VAD-FMK is a cell permeable, irreversible biotin-labeled caspase inhibitor, used to identify active caspases in cell lysates.

Biotin-VAD-FMK	Caspase	Cancer
Biotin-VAD-FMK is a cell permeable, irreversible biotin-labeled caspase inhibitor, used to identify active caspases in cell lysates.

HY-153613

Ac-PLVE-FMK Ac-Pro-Leu-Val-Glu(OMe)-CH2F	Others	Cancer
Ac-PLVE-FMK (Ac-Pro-Leu-Val-Glu(OMe)-CH2F), a tetrapeptidyl m-FMKs, is a Cats inhibitor. Ac-PLVE-FMK can be used for the research of cancer .

HY-P5989

Calpain inhibitor V Mu-Val-HPh-FMK	Antibiotic	Infection
Calpain inhibitor V (Mu-Val-HPh-FMK) is a cell-permeable and irreversible inhibitor of calpain that has anti-chlamydial activity .

HY-115733

Cathepsin L-IN-2

(Rac)-Z-Phe-Phe-FMK
Cathepsin Cancer

Cathepsin L-IN-2 (Z-Phe-Phe-FMK) is a potent and irreversible cathepsin L and cathepsin B inhibitor .

Cathepsin L-IN-2 (Rac)-Z-Phe-Phe-FMK	Cathepsin	Cancer
Cathepsin L-IN-2 (Z-Phe-Phe-FMK) is a potent and irreversible cathepsin L and cathepsin B inhibitor .

HY-126226

MK-6240 Precursor	Others	Cancer
MK-6240 Precursor (6e) is the synthetic precursor of (18)F]-MK-6240. (18)F]-MK-6240 is a tau positron emission tomography (PET) tracer for neurofibrillary tangles (NFTs), exhibiting high specificity and selectivity for binding to NFTs .

HY-52101

CMK

5+ Cited Publications

Ribosomal S6 Kinase (RSK) Cancer

CMK is a RSK2 kinase inhibitor which exhibits similar potency but less chemical stability compared with FMK.

CMK 5+ Cited Publications	Ribosomal S6 Kinase (RSK)	Cancer
CMK is a RSK2 kinase inhibitor which exhibits similar potency but less chemical stability compared with FMK.

HY-10397A

MX1013 2 Publications Verification CV1013; Z-VD-FMK	Caspase	Cancer
MX1013 is a potent, irreversible dipeptide caspase inhibitor vith antiapoptotic activity. MX1013 inhibits recombinant human caspase 3 with an IC₅₀ of 30 nM .

HY-14909

Bardoxolone 10+ Cited Publications CDDO; RTA 401	Keap1-Nrf2 Necroptosis	Metabolic Disease
Bardoxolone (CDDO) is a novel nuclear regulatory factor (Nrf-2) activator for the study of chronic kidney disease. Bardoxolone is a potent necroptosis inhibitor that inhibits Z-VAD-FMK-induced necroptosis .

HY-103348

Boc-Asp(OMe)-fluoromethyl ketone Boc-Asp(OMe)-FMK	Caspase	Inflammation/Immunology
Boc-Asp(OME)-Fluoromethyl Ketone is a broad range caspase inhibitor that inhibits Fas-mediated phagocytosis and oxidative rupture inhibition, but does not affect the chemotactic activity of IL-8 .

HY-163390

RIP1 kinase inhibitor 9	RIP kinase Necroptosis	Inflammation/Immunology Cancer
RIP1 kinase inhibitor 9 (compound SY-1) is a selective RIP kinase inhibitor. RIP1 kinase inhibitor 9 effectively suppresses the central inflammatory response induced by epilepsy. RIP1 kinase inhibitor 9 inhibits Z-VAD-FMK (HY-16658B)-induced necroptosis in HT-29 cells with an EC₅₀ of 7.04 nM .

FITC-C6-DEVD-FMK	Fluorescent Dyes/Probes
FITC-C6-DEVD-FMK, a fluorescently labeled caspase-3 inhibitor, can be used for detection of active caspase-3 in mammalian cells undergoing apoptosis. FITC-C6-DEVD-FMK provides a convenient means for sensitive detection of activated caspase-3 in living cells. Z-DEVD-FMK is a specific caspase-3 inhibitor .

FITC-C6-LEHD-FMK	Fluorescent Dyes/Probes
FITC-C6-LEHD-FMK, a fluorescently labeled caspase-9 inhibitor, can be used for detection of active caspase-9 in mammalian cells undergoing apoptosis. FITC-C6-LEHD-FMK provides a convenient means for sensitive detection of activated caspase-9 in living cells. Z-LEHD-FMK is a specific caspase-9 inhibitor .

Biotin-VAD-FMK	Cell Assay Reagents
Biotin-VAD-FMK is a cell permeable, irreversible biotin-labeled caspase inhibitor, used to identify active caspases in cell lysates.

Cat. No.	Product Name	Target	Research Area

HY-101297

Z-IETD-FMK Maximum Cited Publications 37 Publications Verification Z-IE(OMe)TD(OMe)-FMK	Caspase	Cancer
Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a selective and cell permeable caspase-8 inhibitor . Z-IETD-FMK is also a granzyme B inhibitor .

HY-P1009

Z-YVAD-FMK

10+ Cited Publications

Caspase Cancer

Z-YVAD-FMK is a cell-permeable caspase-1 and -4 inhibitor with anti-inflammatory and anti-tumor activities .

HY-P1007

Z-VEID-FMK Z-VE(OMe)ID(OMe)-FMK	Caspase Apoptosis	Cancer
Z-VEID-FMK (Z-VE(OMe)ID(OMe)-FMK) is a selective and irreversible caspase-6 peptide inhibitor. Z-VEID-FMK alleviates the S-(+)-ketamine-induced augmentation of caspase-6 activity, DNA fragmentation, and cell apoptosis .

HY-141867

Z-FF-FMK Z-Phe-Phe-FMK	Cathepsin	Neurological Disease
Z-FF-FMK is a selective cathepsin-L inhibitor. Z-FF-FMK can prevent β-amyloid to induce apoptotic changes such as activation of caspase-3, cleavage of the DNA repair enzyme, poly-ADP ribose polymerase, and DNA fragmentation .

HY-P5975

Z-Leu-Leu-Leu-fluoromethyl ketone Z-LLL-FMK	Cathepsin SARS-CoV	Infection
Z-Leu-Leu-Leu-fluoromethyl ketone (Z-LLL-FMK) is a cysteine protease inhibitor. Z-Leu-Leu-Leu-fluoromethyl ketone inhibits SARS infection. Z-Leu-Leu-Leu-fluoromethyl ketone also protects mice against a T. crassiceps challenge .

HY-P1008

Z-VDVAD-FMK

Z-VD(OMe)VAD(OMe)-FMK
Caspase Cancer

Z-VDVAD-FMK is a special inhibitor of caspase-2. Z-VDVAD-FMK produces a reduction in Lovastatin-induced apoptosis .

HY-P0111

Z-WEHD-FMK 2 Publications Verification Z-WE(OMe)HD(OMe)-FMK	Caspase Cathepsin	Cancer
Z-WEHD-FMK is a potent, cell-permeable and irreversible caspase-1/5 inhibitor. Z-WEHD-FMK also exhibits a robust inhibitory effect on cathepsin B activity (IC₅₀=6 μM). Z-WEHD-FMK can be used to investigate cells for evidence of apoptosis .

HY-P5122

Z-LEED-FMK

Caspase Inflammation/Immunology

Z-LEED-FMK is a caspase-13 and caspase-4 inhibitor. Z-LEED-FMK also inhibits caspase-1 processing in S. typhimurium-infected macrophages .

HY-P1010

Z-LEHD-FMK 5+ Cited Publications	Caspase Apoptosis	Neurological Disease Cancer
Z-LEHD-FMK is a selective and irreversible inhibitor of caspase-9, protects against lethal reperfusion injury and attenuates apoptosis. Z-LEHD-FMK exhibits the neuroprotective effect in a rat model of spinal cord trauma .

HY-P1010A

*Z-LEHD-FMK* TFA**	Caspase Apoptosis	Neurological Disease Cancer
Z-LEHD-FMK TFA is a selective and irreversible inhibitor of caspase-9, protects against lethal reperfusion injury and attenuates apoptosis. Z-LEHD-FMK TFA exhibits the neuroprotective effect in a rat model of spinal cord trauma .

HY-138203

Z-LE(OMe)TD(OMe)-FMK

Caspase Apoptosis Cancer

Z-LE(OMe)TD(OMe)-FMK is a selective caspase-8 inhibitor. Z-LE(OMe)TD(OMe)-FMK can inhibit cell apoptosis .

HY-P1407

*Z-VRPR-FMK* TFA** VRPR	MALT1 Influenza Virus	Infection Cancer
Z-VRPR-FMK (TFA) (VRPR), a tetrapeptide, is a selective and irreversible MALT1 (Mucosa-associated lymphoid tissue lymphoma translocation protein 1) inhibitor. Z-VRPR-FMK (TFA) can protect against influenza A virus (IAV) infection .

HY-P5989

Calpain inhibitor V Mu-Val-HPh-FMK	Antibiotic	Infection
Calpain inhibitor V (Mu-Val-HPh-FMK) is a cell-permeable and irreversible inhibitor of calpain that has anti-chlamydial activity .

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