IRS

By Targets:	Adrenergic Receptor (1) Akt (2) AMPK (1) GCGR (1) Glucosidase (1) GLUT (1) HDAC (1) Imidazoline Receptor (1) Insulin Receptor (5) JNK (1) MEK (1) MMP (1) mTOR (1) Phosphatase (1) PPAR (1) Prolyl Endopeptidase (PREP) (2) Ribosomal S6 Kinase (RSK) (1) Small Interfering RNA (siRNA) (3) STAT (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (1) Endocrinology (1) Inflammation/Immunology (4) Metabolic Disease (6) Neurological Disease (4)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-115461

MID-1	Insulin Receptor	Metabolic Disease
MID-1 is a disruptor of *MG53-IRS-1* (Mitsugumin 53-insulin receptor substrate-1) interaction. MID-1 disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skeletal muscle, leading to elevated IRS-1 expression level and increased insulin signaling and glucose uptake .

HY-145935

NT219	Insulin Receptor STAT	Cancer
NT219 is a potent and dual inhibitor of insulin receptor substrates 1/2 (IRS1/2) and STAT3. IRS1/2 and STAT3 are major signaling junctions regulated by various oncogenes. NT219 affects IRS1/2 degradation and inhibits STAT3 phosphorylation. NT219 has the potential for the research of cancer diseases .

HY-RS06917

IRS1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IRS1 Human Pre-designed siRNA Set A contains three designed siRNAs for IRS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IRS1 Human Pre-designed siRNA Set A IRS1 Human Pre-designed siRNA Set A

HY-RS06918

IRS2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IRS2 Human Pre-designed siRNA Set A contains three designed siRNAs for IRS2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IRS2 Human Pre-designed siRNA Set A IRS2 Human Pre-designed siRNA Set A

HY-RS06919

IRS4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IRS4 Human Pre-designed siRNA Set A contains three designed siRNAs for IRS4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IRS4 Human Pre-designed siRNA Set A IRS4 Human Pre-designed siRNA Set A

HY-100037

NT157 1 Publications Verification Tyrphostin NT157
NT157 (Tyrphostin NT157) is a selective *IRS-1/2* inhibitor that induces Ser-phosphorylation and consequently the degradation of IRS-1/2. NT157 (Tyrphostin NT157) is a first-in-class anti-cancer agent that also targets Stat3 signaling pathway .

HY-153479

Aganirsen

Insulin Receptor Inflammation/Immunology

Aganirsen is a 25 mer DNA antisense oligonucleotide, which silences expression of insulin receptor substrate-1 (IRS-1).

Aganirsen	Insulin Receptor	Inflammation/Immunology
Aganirsen is a 25 mer DNA antisense oligonucleotide, which silences expression of insulin receptor substrate-1 (IRS-1).

HY-153479A

Aganirsen sodium	Insulin Receptor	Inflammation/Immunology
Aganirsen sodium is a 25 mer DNA antisense oligonucleotide, which silences expression of insulin receptor substrate-1 (IRS-1).

HY-N7676

Marein	AMPK HDAC	Cardiovascular Disease Neurological Disease Metabolic Disease
Marein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway. Marein improves insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3β to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis. Marein is a HDAC inhibitor with an IC₅₀ of 100 µM. Marein has beneficial antioxidative, antihypertensive, antihyperlipidemic and antidiabetic effects .

HY-N0479

Licarin B (-)-Licarin B	PPAR GLUT	Metabolic Disease
Licarin B, a nitric oxide production inhibitor extracted from the component of the seeds of Myristica fragrans, improves insulin sensitivity via PPARγ and activation of GLUT4 in the IRS-1/PI3K/AKT pathway .

HY-107758

Y-29794 oxalate	Prolyl Endopeptidase (PREP)	Cancer
Y-29794 oxalate is a selective, orally active and blood-brain barrier permeable non-peptide prolyl endopeptidase inhibitor. Y-29794 oxalate blocks the *IRS1-AKT-mTORC1* pathway and inhibits tumor growth. Y-29794 oxalate is also effective in inhibiting the progression of Aβ-like deposition in the hippocampus of aging-accelerated mice (SAM) .

HY-15113A

Y-29794 tosylate	Prolyl Endopeptidase (PREP)	Neurological Disease Cancer
Y-29794 tosylate is a selective, orally active inhibitor for non-peptide prolyl endopeptidase (PPCE), with an IC₅₀ of 3 nM and a K_i of 0.95 nM. Y-29794 tosylate enhances the effect of thyrotropin-releasing hormone (TRH) on the release of ACh in the rat hippocampus, exhibits potential neuroprotective efficacy. Y-29794 tosylate exhibits anticancer activity through inhibition of the *IRS1-AKT-mTORC1* pathway. Y-29794 tosylate penetrates the brain-blood barrier (BBB) .

HY-N3628

Coronarin A	mTOR Ribosomal S6 Kinase (RSK)	Metabolic Disease Inflammation/Immunology
Coronarin A is an orally active natural compound that inhibits mTORC1 and S6K1 to increase IRS1 activity. Coronarin A shows anti-inflammatory activity and can also be used for type 2 diabetes mellitus research .

HY-N3542

Carpachromene	Glucosidase	Cancer
Carpachromene is a potent α-glucosidase enzyme inhibitor. Carpachromene ameliorates insulin resistance in HepG2 cells via modulating IR/IRS1/PI3k/Akt/GSK3/FoxO1 pathway .

HY-P0119

Lixisenatide 1 Publications Verification	GCGR MEK Akt MMP JNK	Neurological Disease Metabolic Disease Inflammation/Immunology
Lixisenatide is a GLP-1 receptor agonist. Lixisenatide inhibits the inflammatory response through down regulation of proinflammatory cytokines, and blocks of cellular signaling pathways. Lixisenatide decreases atheroma plaque size and instability in Apoe ^−/− Irs* ^2+/−* mice by reprogramming macrophages towards an M2 phenotype, which leads to reduced inflammation .

HY-14561A

Idazoxan hydrochloride RX 781094 hydrochloride	Adrenergic Receptor Imidazoline Receptor	Neurological Disease Endocrinology
Idazoxan hydrochloride (RX 781094 hydrochloride) is an α₂-adrenoceptor antagonist and is also a imidazoline receptors (IRs) antagonist competitively antagonized the centrally induced hypotensive effect of imidazoline-like agents (IMs). Idazoxan hydrochloride also improves motor symptoms in Parkinson’s disease, L-DOPA-induced dyskinesias, and experimental Parkinsonism .

HY-161321

PTP1B-IN-24	Phosphatase Insulin Receptor Akt	Metabolic Disease
PTP1B-IN-24 (Compound 9) is a reversible PTP1B inhibitor with an IC₅₀ value of 1.4 μM, and PTP1B-IN-24 can enhance the thermal stability of PTP1B. PTP1B-IN-24 can restore PA- (HY-N0830) induced insulin resistance by increasing the phosphorylation levels of *IRS1* and AKT .

Cat. No.	Product Name	Target	Research Area

HY-P5433

IRS1-derived peptide	Peptides	Others
IRS1-derived peptide is a biological active peptide. (This is a peptide fragment (979-989) of the insulin receptor substrate-1 containing the sequence motif YMXM known to bind to the two domains of SH2 on the 85kDa subunit of phosphoinositide 3-kinase.)

HY-P0119

Lixisenatide 1 Publications Verification	GCGR MEK Akt MMP JNK	Neurological Disease Metabolic Disease Inflammation/Immunology
Lixisenatide is a GLP-1 receptor agonist. Lixisenatide inhibits the inflammatory response through down regulation of proinflammatory cytokines, and blocks of cellular signaling pathways. Lixisenatide decreases atheroma plaque size and instability in Apoe ^−/− Irs* ^2+/−* mice by reprogramming macrophages towards an M2 phenotype, which leads to reduced inflammation .

HY-P5433F

IRS-1 Peptide, FAM labeled

Peptides Others

IRS-1 Peptide, FAM labeled is a biological active peptide. (Insulin receptor substrate)

IRS-1 Peptide, FAM labeled	Peptides	Others
IRS-1 Peptide, FAM labeled is a biological active peptide. (Insulin receptor substrate)

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7676

Marein	Cardiovascular Disease Flavonoids Chalcones other families Classification of Application Fields Neurological Disease Source classification Phenols Polyphenols Plants Disease Research Fields	AMPK HDAC
Marein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway. Marein improves insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3β to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis. Marein is a HDAC inhibitor with an IC₅₀ of 100 µM. Marein has beneficial antioxidative, antihypertensive, antihyperlipidemic and antidiabetic effects .

HY-N0479

Licarin B (-)-Licarin B	Classification of Application Fields Simple Phenylpropanols Source classification Metabolic Disease Myristicaceae Phenylpropanoids Plants Myristica fragrans Houtt. Disease Research Fields	PPAR GLUT
Licarin B, a nitric oxide production inhibitor extracted from the component of the seeds of Myristica fragrans, improves insulin sensitivity via PPARγ and activation of GLUT4 in the IRS-1/PI3K/AKT pathway .

HY-N3628

Coronarin A	Hedychium coronarium Koen. Natural Products Plants Zingiberaceae	mTOR Ribosomal S6 Kinase (RSK)
Coronarin A is an orally active natural compound that inhibits mTORC1 and S6K1 to increase IRS1 activity. Coronarin A shows anti-inflammatory activity and can also be used for type 2 diabetes mellitus research .

HY-N3542

Carpachromene	Structural Classification Flavonoids Flavones Source classification Plants Calophyllaceae Calophyllum symingtonianum M.R.Hend. & Wyatt-Sm.	Glucosidase
Carpachromene is a potent α-glucosidase enzyme inhibitor. Carpachromene ameliorates insulin resistance in HepG2 cells via modulating IR/IRS1/PI3k/Akt/GSK3/FoxO1 pathway .

Cat. No.	Product Name	Application	Reactivity

HY-P81116

IRS1 Antibody IRS1_HUMAN; Insulin receptor substrate 1; IRS-1; IRS 1	WB; ELISA; IHC-P; IHC-F; IF	Human, Mouse, Rat, Pig(predicted: Chicken)
IRS1 Antibody is an unconjugated, approximately 137 kDa, rabbit-derived, anti-IRS1 polyclonal antibody. IRS1 Antibody can be used for: WB, ELISA, IHC-P, IHC-F, IF expriments in human, mouse, rat, pig, and predicted: chicken background without labeling.

HY-P82526

IRS2 Antibody (YA2271)

Insulin receptor substrate 2; IRS 2; IRS-2
WB, IHC-P, ICC/IF, FC Human, Mouse, Rat

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