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Isoforms Recommended:	PAK4

Results for "

PAK4

" in MedChemExpress (MCE) Product Catalog:

標的別:	Apoptosis (6) NAMPT (1) PAK (12) Small Interfering RNA (siRNA) (3)
研究分野別:	Cancer (12)

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製品番号	製品名	Target	研究分野	構造式

HY-143490

PAK4-IN-2	PAK Apoptosis	Cancer
PAK4-IN-2 is a highly potent *PAK4* inhibitor with IC₅₀ value of 2.7 nM. PAK4-IN-2 can arrest MV4-11 cells at G0/G1 phase and induce cell apoptosis. PAK4-IN-2 can be used for researching cancer .

HY-RS09993

PAK4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PAK4 Human Pre-designed siRNA Set A contains three designed siRNAs for PAK4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PAK4 Human Pre-designed siRNA Set A PAK4 Human Pre-designed siRNA Set A

HY-RS09994

Pak4 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pak4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pak4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pak4 Mouse Pre-designed siRNA Set A Pak4 Mouse Pre-designed siRNA Set A

HY-RS09995

Pak4 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pak4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Pak4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pak4 Rat Pre-designed siRNA Set A Pak4 Rat Pre-designed siRNA Set A

HY-130628

PAK4-IN-1	PAK	Cancer
PAK4-IN-1 (Compound 19) is a potent, selective, orally active *PAK4* inhibitor with robust anti-tumor efficacy in vivo. PAK4-IN-1 is stable under both acidic and neutral conditions .

HY-156453

PAK4-IN-3	PAK Apoptosis	Cancer
PAK4-IN-3(compound 27e) is aPAK4inhibitor, with theIC₅₀of 10 nM.PAK4-IN-3shows antiproliferative activity against A549 cells with anIC₅₀value of 0.61μM, and inducesapoptosisof A549 cells in a concentration-dependent manner and blocked the cell cycle at phase G0/G1 .

HY-124764

KY-04031

PAK Cancer

KY-04031 is a potent PAK4 inhibitor with IC₅₀ of 0.79 μM. KY-04031 binds to the ATP-binding pocket of PAK4. KY-04031 blocks tumor cell growth and invasion .

KY-04031	PAK	Cancer
KY-04031 is a potent *PAK4* inhibitor with IC₅₀ of 0.79 μM. KY-04031 binds to the ATP-binding pocket of PAK4. KY-04031 blocks tumor cell growth and invasion .

HY-125035

LCH-7749944 1 Publications Verification GNF-PF-2356	PAK Apoptosis	Cancer
LCH-7749944 (GNF-PF-2356) is a potent *PAK4* inhibitor with an IC₅₀ of 14.93 μM. LCH-7749944 effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis .

HY-13007

PF-3758309 5+ Cited Publications PF-03758309	PAK Apoptosis	Cancer
PF-3758309 (PF-03758309) is a potent, orally available, and reversible ATP-competitive inhibitor of *PAK4* (K_d= 2.7 nM; K_i=18.7 nM). PF-3758309 has the expected cellular functions of a PAK4 inhibitor: inhibition of anchorage-independent growth, induction of apoptosis, cytoskeletal remodeling, and inhibition of proliferation .

HY-13007B

PF-3758309 dihydrochloride PF-03758309 dihydrochloride	PAK Apoptosis	Cancer
PF-3758309 (PF-03758309) dihydrochloride is a potent, orally available, and reversible ATP-competitive inhibitor of *PAK4* (K_d= 2.7 nM; K_i=18.7 nM). PF-3758309 dihydrochloride has the expected cellular functions of a PAK4 inhibitor: inhibition of anchorage-independent growth, induction of apoptosis, cytoskeletal remodeling, and inhibition of proliferation .

HY-13007A

PF-3758309 hydrochloride PF-03758309 hydrochloride	PAK Apoptosis	Cancer
PF-3758309 (PF-03758309) hydrochloride is a potent, orally available, and reversible ATP-competitive inhibitor of *PAK4* (K_d= 2.7 nM; K_i=18.7 nM). PF-3758309 hydrochloride has the expected cellular functions of a PAK4 inhibitor: inhibition of anchorage-independent growth, induction of apoptosis, cytoskeletal remodeling, and inhibition of proliferation .

HY-12793

Padnarsertib 1 Publications Verification KPT-9274	PAK NAMPT	Cancer
Padnarsertib (KPT-9274) is an orally bioavailable, dual *PAK4/Nicotinamide* phosphoribosyltransferase (Nampt) inhibitor, with IC₅₀s of <100 nM and 120 nM, respectively .

HY-19538

FRAX1036

2 Publications Verification

PAK Cancer

FRAX1036 is a PAK inhibitor with K_is of 23.3 nM, 72.4 nM, and 2.4 μM for PAK1, PAK2 and PAK4, respectively.
HY-12632

GNE 2861

PAK Cancer

GNE 2861 is a PAK inhibitor that displays group II selectivity. GNE 2861 inhibits PAK4, PAK5 and PAK6 with IC₅₀s of 7.5, 36, 126 nM, respectively.

FRAX1036 2 Publications Verification	PAK	Cancer
FRAX1036 is a *PAK* inhibitor with K_is of 23.3 nM, 72.4 nM, and 2.4 μM for PAK1, PAK2 and PAK4, respectively.

GNE 2861	PAK	Cancer
GNE 2861 is a *PAK* inhibitor that displays group II selectivity. GNE 2861 inhibits PAK4, PAK5 and PAK6 with IC₅₀s of 7.5, 36, 126 nM, respectively.

HY-15663

IPA-3 Maximum Cited Publications 13 Publications Verification	PAK	Cancer
IPA-3 is a selective non-ATP competitive *PAK1* inhibitor with IC₅₀ of 2.5 μM, and shows no inhibition to group II PAKs (PAKs 4-6).

Species:	Human (2)
Tag:	SUMO (1) His (2)
Source:	E. coli (2)

製品番号	Compare	製品名	Species	Source

HY-P700575

	PAK4 Protein, Human (His-SUMO) p21-activated kinase 4 ; PAK-4	Human	E. coli
	PAK4 is an important serine/threonine kinase that affects cytoskeletal regulation, cell migration, growth, and survival through multiple pathways. Activation triggered by various effectors induces autophosphorylation, targeting proteins such as SSH1 and LIMK1 to regulate cofilin activity and stabilize actin filaments. PAK4 Protein, Human (His-SUMO) is the recombinant human-derived PAK4 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag. The total length of PAK4 Protein, Human (His-SUMO) is 426 a.a., with molecular weight of 63.9 kDa.

HY-P702747

	PAK4 Protein, Human (His) PAK4; p21 protein (Cdc42/Rac)-activated kinase 4; p21(CDKN1A) activated kinase 4; serine/threonine-protein kinase PAK 4; PAK-4; p21-activated kinase 4; p21(CDKN1A)-activated kinase 4; protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs	Human	E. coli


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