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Isoforms Recommended: PI3Kγ
Results for "

PI3K-γ

" in MedChemExpress (MCE) Product Catalog:

83

Inhibitors & Agonists

5

Natural
Products

3

Isotope-Labeled Compounds

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-132299

    PI3K Inflammation/Immunology
    PI3Kγ inhibitor 4 is a potent, selective and orally active inhibitor of PI3, with an IC50 of 40 nM. PI3Kγ inhibitor 4 shows ∼7, 43, and 18-fold selectivity for PI3Kγ over the α, β, and δ isoforms, respectively. PI3Kγ inhibitor 4 can be used for the research of airway inflammation .
    <em>PI3</em>Kγ inhibitor 4
  • HY-148317

    PI3K Inflammation/Immunology
    PI3Kγ inhibitor 6 (compound 9) is a PI3 inhibitor. PI3Kγ inhibitor 6 can be used for the research of inflammatory and autoimmune diseases .
    <em>PI3</em>Kγ inhibitor 6
  • HY-139880

    PI3K Cancer
    PI3Kγ inhibitor 5 is an inhibitor of phosphoinositide 3-kinase γ (PI3Kγ) with an IC50 value of 34 nM.
    <em>PI3</em>Kγ inhibitor 5
  • HY-112286

    PI3K Inflammation/Immunology
    PI3Kγ inhibitor 2 (Compound 16) is an orally bioavailable, CNS-penetrant, isoform selective PI3 inhibitor with a Ki of 4 nM .
    <em>PI3</em>Kγ inhibitor 2
  • HY-153703

    PI3K Cancer
    PI3Kγ inhibitor 7 (compound 2) is a potent and orally active PI3 inhibitor with IC50 values of 4768, 878.1, 3.42, 355.2 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, respectively. PI3Kγ inhibitor 7 shows antitumor activity . PI3Kγ inhibitor 7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    <em>PI3</em>Kγ inhibitor 7
  • HY-10549

    PI3K Cancer
    PI3Kγ inhibitor 1 is a PI3 and PI3 inhibitor extracted from patent WO2014004470A1, Compound 168 in Table 4, has IC50s of <100 nM.
    <em>PI3</em>Kγ inhibitor 1
  • HY-11080

    PI3K mTOR Cancer
    PKI-179 is a potent and orally active dual PI3K/mTOR inhibitor, with IC50s of 8 nM, 24 nM, 74 nM, 77 nM, and 0.42 nM for PI3K-α, PI3K-β, PI3K-γ, PI3K-δ and mTOR, respectively. PKI-179 also exhibits activity over E545K and H1047R, with IC50s of 14 nM and 11 nM, respectively. PKI-179 shows anti-tumor activity in vivo .
    PKI-179
  • HY-11080A

    PI3K mTOR Cancer
    PKI-179 hydrochloride is a potent and orally active dual PI3K/mTOR inhibitor, with IC50s of 8 nM, 24 nM, 74 nM, 77 nM, and 0.42 nM for PI3K-α, PI3K-β, PI3K-γ, PI3K-δ and mTOR, respectively. PKI-179 hydrochloride also exhibits activity over E545K and H1047R, with IC50s of 14 nM and 11 nM, respectively. PKI-179 hydrochloride shows anti-tumor activity in vivo .
    PKI-179 hydrochloride
  • HY-111570

    PI3K Inflammation/Immunology
    AZ2 is a highly selective PI3 inhibitor (The pIC50 value for PI3 is 9.3). AZ2 can be used for the research of inflammatory and immune diseases .
    AZ2
  • HY-13530
    CAY10505
    3 Publications Verification

    PI3K Apoptosis Cancer
    CAY10505 is a potent and selective PI3 inhibitor with an IC50 of 30 nM in neurons.
    CAY10505
  • HY-13532
    AS-252424
    3 Publications Verification

    PI3K Cancer
    AS-252424 is a potent and selective PI3 inhibitor with an IC50 of 30±10 nM.
    AS-252424
  • HY-112443

    PI3K Metabolic Disease Inflammation/Immunology Cancer
    AZD3458 is a potent and remarkably selective PI3 inhibitor with pIC50s of 9.1, 5.1, <4.5, and 6.5 for PI3, PI3, PI3, and PI3, respectively .
    AZD3458
  • HY-10109
    AS-605240
    5 Publications Verification

    PI3K Autophagy Cancer
    AS-605240 is a specific and orally active inhibitor of the PI3, with an IC50 of 8 nM, and a Ki of 7.8 nM.
    AS-605240
  • HY-15294

    PI3K Inflammation/Immunology Cancer
    CZC24832 is a highly selective and potent PI3 inhibitor (IC50=27 nM) with apparent dissociation constants (Kd app) of 19 nM.
    CZC24832
  • HY-112897

    Autophagy PI3K Apoptosis Cancer
    IITZ-01 is a potent lysosomotropic autophagy inhibitor with single-agent antitumor activity, with an IC50 of 2.62 μM for PI3Kγ.
    IITZ-01
  • HY-13531
    AS-604850
    1 Publications Verification

    PI3K Cancer
    AS-604850 is a potent, selective and ATP-competitive PI3 inhibitor with an IC50 value of 0.25 μM and a Ki value of 0.18 μM. AS-604850 shows isoform selective inhibitor of PI3 with over 30-fold selectivity for PI3Kδ and β, and 18-fold selectivity over PI3Kα, respectively .
    AS-604850
  • HY-16122A

    PI3K Cancer
    CAL-130 is a PI3 and PI3 inhibitor with IC50s of 1.3 and 6.1 nM, respectively.
    CAL-130
  • HY-16122B

    PI3K Cancer
    CAL-130 is a PI3 and PI3 inhibitor with IC50s of 1.3 and 6.1 nM, respectively.
    CAL-130 Hydrochloride
  • HY-17645
    Tenalisib
    1 Publications Verification

    RP6530

    PI3K Cancer
    Tenalisib (RP6530) is a novel, potent, and selective PI3 and PI3 inhibitor with IC50 values of 25 and 33 nM, respectively.
    Tenalisib
  • HY-161366

    PI3K Cancer
    OMS14 is exhibits inhibitory activity for phosphoinositide 3-kinase γ (PI3Kγ) and PIK3CD/PIK3R1, which inhibits 19% PI3Kγ and 65% PIK3CD/PIK3R1 activity at 100 μM. OMS14 exhibits anticancer efficacy in various cancer cells .
    OMS14
  • HY-100716
    Eganelisib
    10+ Cited Publications

    IPI-549

    PI3K Cancer
    Eganelisib (IPI549) is a potent and selective PI3 inhibitor with an IC50 of 16 nM. Eganelisib shows >100-fold selectivity over other lipid and protein kinases .
    Eganelisib
  • HY-112172

    RP6530 R Enantiomer

    PI3K Cancer
    Tenalisib R Enantiomer (RP6530 R Enantiomer) is an R enantiomer of Tenalisib. Tenalisib is a potent and selective PI3Kδ and PI3Kγ inhibitor with IC50 values of 25 and 33 nM, respectively .
    Tenalisib R Enantiomer
  • HY-133907

    PI3K Inflammation/Immunology Cancer
    NVS-PI3-4 is a specific PI3 inhibitor. NVS-PI3-4 can be used for the research of allergies, inflammatory and cancer diseases .
    NVS-PI<em>3</em>-4
  • HY-120438

    PI3K Akt Inflammation/Immunology
    TASP0415914 is a potent and orally active PI3 inhibitor with an IC50 of 29 nM. TASP0415914 also shows potent Akt inhibitory activities with an IC50 of 294 nM. TASP0415914 can be used for inflammatory diseases research .
    TASP0415914
  • HY-12046
    PIK-93
    4 Publications Verification

    PI4K PI3K Virus Protease Cancer
    PIK-93 is the first potent, synthetic PI4K (PI4KIIIβ) inhibitor with IC50 of 19 nM, and also inhibits PI3 and PI3 with IC50 of 16 nM and 39 nM, respectively.
    PIK-93
  • HY-101146
    SF2523
    2 Publications Verification

    PI3K Epigenetic Reader Domain DNA-PK Cancer
    SF2523 is a highly selective and potent inhibitor of PI3K with IC50s of 34 nM, 158 nM, 9 nM, 241 nM and 280 nM for PI3, PI3, DNA-PK, BRD4 and mTOR, respectively.
    SF2523
  • HY-D0254
    Gallein
    4 Publications Verification

    Pyrogallol phthalein

    PI3K Cancer
    Gallein is a G protein βγ (Gβγ) subunit signalling inhibitor. Gallein disrupts the interaction of Gβγ subunits with the PI3Kγ. Anticancer agent . Gallein used as a red dye, an acid-base indicator and as a detection reagent for phosphates .
    Gallein
  • HY-50847
    ZSTK474
    10+ Cited Publications

    PI3K Autophagy Cancer
    ZSTK474 is an ATP-competitive pan-class I PI3K inhibitor with IC50s of 16 nM, 44 nM, 4.6 nM and 49 nM for PΙ3Κα, PI3Kβ, PI3Kδ and PI3Kγ, respectively.
    ZSTK474
  • HY-13333

    BAG 956

    PI3K Cancer
    NVP-BAG956 is an ATP-competitive PI3K inhibitor with IC50s of 34, 56, 112 and 444 nM for PI3Kδ, PI3Kα, PI3Kγ and PI3Kβ, respectively.
    NVP-BAG956
  • HY-18085
    Quercetin
    Maximum Cited Publications
    61 Publications Verification

    PI3K Autophagy Mitophagy Reactive Oxygen Species Apoptosis Cancer
    Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .
    Quercetin
  • HY-10681
    Gedatolisib
    4 Publications Verification

    PKI-587; PF-05212384

    PI3K mTOR Cancer
    Gedatolisib (PKI-587) is a highly potent dual inhibitor of PI3, PI3, and mTOR with IC50s of 0.4 nM, 5.4 nM and 1.6 nM, respectively . Gedatolisib is equally effective in both complexes of mTOR, mTORC1 and mTORC2 .
    Gedatolisib
  • HY-18085A

    PI3K Autophagy Mitophagy Apoptosis Reactive Oxygen Species Cancer
    Quercetin hydrate, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .
    Quercetin hydrate
  • HY-19962
    Paxalisib
    2 Publications Verification

    GDC-0084

    PI3K mTOR Cancer
    Paxalisib (GDC-0084) is a brain penetrant inhibitor of PI3K and mTOR, with Kis of 2 nM, 46 nM, 3 nM, 10 nM and 70 nM for PI3PI3Kβ, PI3Kδ, PI3Kγ and mTOR, respectively .
    Paxalisib
  • HY-16526
    Pilaralisib
    3 Publications Verification

    XL-147; SAR245408

    PI3K Cancer
    Pilaralisib (XL147; SAR245408) is a potent and highly selective class I PI3Ks inhibitor with IC50s of 39 nM, 383 nM, 23 nM and 36 nM for PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ.
    Pilaralisib
  • HY-N0146
    Quercetin dihydrate
    Maximum Cited Publications
    61 Publications Verification

    PI3K Apoptosis Inflammation/Immunology Cancer
    Quercetin dihydrate, a natural flavonoid, is a stimulator of recombinant SIRT1 and a PI3K inhibitor with IC50s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .
    Quercetin dihydrate
  • HY-15271
    WYE-687
    3 Publications Verification

    mTOR PI3K Cancer
    WYE-687 is an ATP-competitive mTOR inhibitor with an IC50 of 7 nM. WYE-687 concurrently inhibits activation of mTORC1 and mTORC2. WYE-687 also inhibits PI3 and PI3 with IC50s of 81 nM and 3.11 μM, respectively.
    WYE-687
  • HY-13898
    Taselisib
    15+ Cited Publications

    GDC-0032; RG-7604

    PI3K Cancer
    Taselisib (GDC-0032) is a potent PI3K inhibitor targets PIK3CA mutations, with Kis of 0.12 nM, 0.29 nM, 0.97 nM, and 9.1 nM for PI3Kδ, PI3Kα, PI3Kγ and PI3Kβ, respectively.
    Taselisib
  • HY-19798
    PI4KIIIbeta-IN-9
    5 Publications Verification

    PI4K PI3K Cancer
    PI4KIIIbeta-IN-9 is a potent PI4KIIIβ inhibitor with an IC50 of 7 nM. PI4KIIIbeta-IN-9 also inhibits PI3 and PI3 with IC50s of 152 nM and 1046 nM, respectively.
    PI4KIIIbeta-IN-9
  • HY-15271A

    mTOR PI3K Cancer
    WYE-687 dihydrochloride is an ATP-competitive mTOR inhibitor with an IC50 of 7 nM . WYE-687 dihydrochloride concurrently inhibits activation of mTORC1 and mTORC2 . WYE-687 also inhibits PI3 and PI3 with IC50s of 81 nM and 3.11 μM, respectively .
    WYE-687 dihydrochloride
  • HY-147419

    PI3K Cancer
    Vulolisib is a potent and orally active phosphatidylinositol 3-kinase (PI3K) inhibitor, with IC50 values of 0.2 nM, 168 nM, 90 nM and 49 nM for PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ, respectively. Antiproliferative and antineoplastic activity .
    Vulolisib
  • HY-10811
    GNE-493
    2 Publications Verification

    PI3K mTOR Cancer
    GNE-493 is a potent, selective, and orally available dual pan-PI3-kinase/mTOR inhibitor with IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR.
    GNE-493
  • HY-13431
    KU-0060648
    1 Publications Verification

    DNA-PK PI3K mTOR Cancer
    KU-0060648 is a dual inhibitor of PI3K and DNA-PK with IC50s of 4 nM, 0.5 nM, 0.1 nM, 0.594 nM and 8.6 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ and DNA-PK, respectively .
    KU-0060648
  • HY-13334
    BGT226 maleate
    5 Publications Verification

    NVP-BGT226 maleate

    PI3K mTOR Autophagy Apoptosis Cancer
    BGT226 (NVP-BGT226 maleate) is a PI3K (with IC50s of 4 nM, 63 nM and 38 nM for PI3, PI3 and PI3) /mTOR dual inhibitor which displays potent growth-inhibitory activity against human head and neck cancer cells .
    BGT226 maleate
  • HY-12330
    AZD8186
    5 Publications Verification

    PI3K Cancer
    AZD8186 is a PI3K inhibitor, which potently inhibits PI3Kβ (IC50=4 nM) and PI3Kδ (IC5050=12 nM) with selectivity over PI3Kα (IC50=35 nM) and PI3Kγ (IC50=675 nM).
    AZD8186
  • HY-18085S1

    Isotope-Labeled Compounds PI3K Autophagy Mitophagy Reactive Oxygen Species Apoptosis Cancer
    Quercetin-d3 is the deuterium labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively[1].
    Quercetin-d<em>3</em>
  • HY-101517

    PI3K Cancer
    PI3K-IN-2 (compound 10) is a potent and orally active PI3Kβ/δ (IC50=7.1/8.6 nM) inhibitor with excellent selectivity versus PI3Kσ and PI3Kγ (IC50=13/190 nM, respectively) .
    PI<em>3</em>K-IN-2
  • HY-18085S

    PI3K Autophagy Mitophagy Apoptosis Cancer
    Quercetin-d5 is a deuterium labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively[1].
    Quercetin-d5
  • HY-12034
    WYE-354
    5 Publications Verification

    mTOR Autophagy Apoptosis Cancer
    WYE-354 is an ATP-competitive mTOR inhibitor with an IC50 of 5 nM. WYE-354 also inhibits PI3 and PI3 with IC50s of 1.89 μM and 7.37 μM, respectively. WYE-354 inhibits both mTORC1 and mTORC2. WYE-354 induces autophagy activation in vitro [3].
    WYE-354
  • HY-18085S2

    Isotope-Labeled Compounds PI3K Autophagy Mitophagy Reactive Oxygen Species Apoptosis Cancer
    Quercetin- 13C3 is the 13C-labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively[1].
    Quercetin-13C<em>3</em>
  • HY-143404

    PI3K Cancer
    PI3K-IN-30 (compound 6d) is a potent PI3K inhibitor with IC50s of 5.1, 136, 30.7 and 8.9 nM for PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ, respectively .
    PI<em>3</em>K-IN-30

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